INT71308

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Context Info
Confidence 0.76
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 33
Total Number 36
Disease Relevance 25.66
Pain Relevance 7.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL11) extracellular space (CCL11) extracellular region (CCL11)
cell adhesion (CCL11) cytoskeleton organization (CCL11)
Anatomy Link Frequency
eosinophils 6
upper 3
plasma 2
epithelial cells 2
smooth muscle cells 2
CCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 462 100.00 Very High Very High Very High
chemokine 293 100.00 Very High Very High Very High
Fibrositis 220 99.76 Very High Very High Very High
dexamethasone 63 99.50 Very High Very High Very High
Inflammation 853 99.00 Very High Very High Very High
cINOD 35 98.68 Very High Very High Very High
agonist 68 97.84 Very High Very High Very High
metalloproteinase 18 94.52 High High
Crohn's disease 13 93.96 High High
headache 5 92.80 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 7 99.84 Very High Very High Very High
Rhinitis 375 99.82 Very High Very High Very High
Hypersensitivity 101 99.52 Very High Very High Very High
Eosinophilia 64 99.16 Very High Very High Very High
INFLAMMATION 994 99.00 Very High Very High Very High
Paranasal Sinus Disease 3 98.80 Very High Very High Very High
Fibromyalgia 214 98.56 Very High Very High Very High
Eosinophilic Esophagitis 222 98.52 Very High Very High Very High
Asthma 1212 98.12 Very High Very High Very High
Disease 271 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart from its functions in the eosinophilic system, eotaxin has been shown to be overexpressed in atherosclerosis.
Gene_expression (overexpressed) of eotaxin associated with rhinitis and increased venous pressure under development
1) Confidence 0.76 Published 2006 Journal J. Investig. Med. Section Abstract Doc Link 17169268 Disease Relevance 0.60 Pain Relevance 0.07
IL-13 is reported to induce eosinophil recruitment into the lung via an IL-5- and eotaxin-dependent mechanism.30 Indeed, several studies have reported that IL-13 induces eotaxin production in epithelial and smooth muscle cells.31,32 In-vivo data have shown that IL-13 stimulates eotaxin in IL-13 transgenic mice.33 The increase in eotaxin-1 levels was proportional to the impaired lung function and bronchial hyper-reactivity in asthmatics, as shown in previous studies.34,35 In this study, we found that the GG genotype of the Arg110Gln (110G>A) polymorphism was associated with a significantly higher eotaxin-1 level, as compared to the AA type; these findings suggest that the 110G allele is associated with eotaxin-1-mediated eosinophilic inflammation.
Gene_expression (production) of eotaxin in lung associated with targeted disruption, rhinitis, inflammation and occupational lung diseases
2) Confidence 0.75 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 0.69 Pain Relevance 0.04
There was no consistent association between the presence of eosinophils and either IL-5 or eotaxin in smooth muscle cells, suggesting that mechanisms other than IL-5 or eotaxin production may account for the eosinophilia.
Gene_expression (production) of eotaxin in eosinophils associated with eosinophilia
3) Confidence 0.75 Published 2001 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 11444199 Disease Relevance 1.69 Pain Relevance 0.12
Also, we analyzed the blood and bronchoalveolar lavage fluid (BAL) for levels of IL-6, IFN-gamma, eotaxin and Regulated on Activation Normal T Cell Expressed and Secreted (RANTES) in experimental murine T. canis infection.
Spec (analyzed) Gene_expression (levels) of eotaxin in blood associated with infection
4) Confidence 0.75 Published 2005 Journal Vet. Parasitol. Section Abstract Doc Link 16168564 Disease Relevance 0.85 Pain Relevance 0.19
Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.
Gene_expression (expression) of eotaxin gene associated with inflammation and cinod
5) Confidence 0.74 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9299399 Disease Relevance 0.69 Pain Relevance 0.18
Patients (56/92) treated with the single agent guaifenesin (>3 months) had higher levels of eotaxin than those not treated (P<0.01).
Gene_expression (levels) of eotaxin
6) Confidence 0.65 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18535166 Disease Relevance 1.10 Pain Relevance 0.65
As shown in Figure 2, MCP-1, IP-10 and eotaxin plasma levels were elevated, on average, for all FMS patients vs. unrelated controls, except those with the rare alleles for the MEFV gene, who were empirically intermediate, but cannot be statistically distinguished from either controls or other FMS patients.
Gene_expression (levels) of eotaxin in plasma associated with fibrositis
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.55 Pain Relevance 0.44
-induced production of eotaxin and monocyte chemotactic protein-1 by airway smooth muscle cells [67].
Gene_expression (production) of eotaxin in smooth muscle cells
8) Confidence 0.58 Published 2007 Journal Respir Res Section Body Doc Link PMC2231357 Disease Relevance 0.54 Pain Relevance 0.30
Mediators (including histamine; cysteinyl leukotrienes; interleukin [IL]-4, IL-5, IL-13; regulated on activation, normal T-cell expressed and secreted [RANTES] chemokine; and eotaxin) are expressed in both upper and lower airways [14,15].
Gene_expression (expressed) of eotaxin in upper associated with chemokine
9) Confidence 0.58 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 1.63 Pain Relevance 0.18
What remains to be explored is the complex connection between the effect of mutations in inflammation-regulating genes, such as MEFV, and environmental effects that sustain the production of harmful chemokines and cytokines, such as MCP-1, eotaxin, and IL-1?.
Gene_expression (production) of eotaxin associated with chemokine, inflammation and cytokine
10) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.77 Pain Relevance 0.45
Mediators (including histamine; cysteinyl leukotrienes; interleukin [IL]-4, IL-5, IL-13; regulated on activation, normal T-cell expressed and secreted [RANTES] chemokine; and eotaxin) are expressed in both upper and lower airways [14,15].
Gene_expression (expressed) of eotaxin in upper associated with chemokine
11) Confidence 0.58 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 1.65 Pain Relevance 0.19
High plasma levels of MCP-1 and eotaxin provide evidence for an immunological basis of fibromyalgia.
Gene_expression (levels) of eotaxin in plasma associated with fibrositis
12) Confidence 0.58 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 18535166 Disease Relevance 1.11 Pain Relevance 0.72
We measured the CSF concentrations of eotaxin and eotaxin-2 of 30 patients and 10 controls.
Gene_expression (concentrations) of eotaxin in CSF
13) Confidence 0.58 Published 2007 Journal Cytokine Section Abstract Doc Link 17703945 Disease Relevance 0.87 Pain Relevance 0.22
The strong eosinophil chemoattractants eotaxin-1 (CCL11), ?
Gene_expression (chemoattractants) of eotaxin-1 in eosinophil
14) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.46 Pain Relevance 0.15
The strong eosinophil chemoattractants eotaxin-1 (CCL11), ?
Gene_expression (chemoattractants) of CCL11 in eosinophil
15) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.46 Pain Relevance 0.15
Some studies have shown that elevated expression of TARC (CCL17), CTACK (CCL27), eotaxin (CCL11), eotaxin-2 (CCL24), and MCP-4 (CCL13) play an important role in the recruitment of CCR4+ or CCR3+ inflammatory cells into human skin in atopic inflammation [26-29].
Gene_expression (expression) of CCL11 in skin associated with inflammation
16) Confidence 0.36 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.73 Pain Relevance 0.22
Additionally, the BTPs show inhibition of IL-4, IL-5, IL-8, and CCL11 production [150,151].
Gene_expression (production) of CCL11
17) Confidence 0.33 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.28 Pain Relevance 0.16
h either with and without eosinophils expressed immunoreactive Eotaxin which was not different in airway epithelium versus within the airway media.
Gene_expression (expressed) of Eotaxin in epithelium
18) Confidence 0.28 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.26 Pain Relevance 0.07
There were no apparent differences (n = 3 determinations from 5 distinct patients) in Eotaxin expression (Figure 10) which occurred constitutively within the bronchial epithelium and airway wall in tissues incubated both with and without eosinophils.


Gene_expression (expression) of Eotaxin in eosinophils
19) Confidence 0.28 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.41 Pain Relevance 0.09
Increased lumen levels of CCL11 have been associated with acute loss of mucosal eosinophils into the tracheal lumen in allergen-challenged guinea-pigs [115].
Gene_expression (levels) of CCL11 in lumen
20) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2900258 Disease Relevance 0.10 Pain Relevance 0.09

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