INT71319

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.15
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) extracellular region (Penk) nucleolus (Fos)
nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
neurons 1
Penk (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
substance P 4 98.56 Very High Very High Very High
qutenza 5 92.72 High High
Hippocampus 2 85.72 High High
cerebral cortex 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Shock 2 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In multiple labelling experiments, c-Fos was examined for co-localization with nitric oxide synthase (NOS), vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), enkephalin (ENK), gastrin-releasing peptide (GRP), substance P (SP), calbindin D-28k (CALB) and neurofilament 145 (NF 145).
ENK Spec (examined) Binding (co-localization) of c-Fos associated with neuropeptide, enkephalin and substance p
1) Confidence 0.40 Published 2003 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 12588467 Disease Relevance 0 Pain Relevance 0.71
The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.
proENK Binding (activities) of c-Fos
2) Confidence 0.37 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
As demonstrated using a variety of double labelling techniques (combination of the immunocytochemical detection of Fos with the autoradiography of mu opioid receptors, calbindin immunocytochemistry, in situ hybridization of preproenkephalin and preprotachykinin A messenger RNAs), striatal neurons which express Fos are mostly localized in the matrix compartment and concern equally enkephaline and substance P containing efferent neurons.
preproenkephalin Binding (hybridization) of Fos in neurons associated with mu opioid receptor and substance p
3) Confidence 0.11 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300404 Disease Relevance 0.15 Pain Relevance 0.20

General Comments

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