INT7132

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Context Info
Confidence 0.81
First Reported 1984
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 53
Total Number 54
Disease Relevance 19.79
Pain Relevance 10.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPPA) nucleus (NPPA) cytoplasm (NPPA)
Anatomy Link Frequency
plasma 5
atrial wall 3
brain 3
atrium 2
cardiocytes 2
NPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 21 100.00 Very High Very High Very High
Catecholamine 14 100.00 Very High Very High Very High
bradykinin 12 100.00 Very High Very High Very High
Endogenous opioid 11 99.92 Very High Very High Very High
cva 5 99.92 Very High Very High Very High
Enkephalin 19 99.86 Very High Very High Very High
narcan 14 99.86 Very High Very High Very High
Dynorphin 21 99.78 Very High Very High Very High
analgesia 129 99.64 Very High Very High Very High
epidural 157 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 230 100.00 Very High Very High Very High
Natriuresis 111 100.00 Very High Very High Very High
Depression 14 100.00 Very High Very High Very High
Hemorrhage 6 99.92 Very High Very High Very High
Heart Rate Under Development 55 99.84 Very High Very High Very High
Coronary Artery Disease 49 99.78 Very High Very High Very High
Cv Unclassified Under Development 41 98.96 Very High Very High Very High
Hematoma 5 98.92 Very High Very High Very High
Diabetic Neuropathy 1 98.64 Very High Very High Very High
Increased Venous Pressure Under Development 13 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Atrial natriuretic factor (ANF) release is modulated by several haemodynamic factors, including ventricular and atrial wall stretch.
Localization (release) of ANF in atrial wall associated with natriuresis
1) Confidence 0.81 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.40 Pain Relevance 0.06
We conclude that dipyridamole infusion does not increase ANF release in man in the absence of ischaemia.
Localization (release) of ANF associated with cv unclassified under development
2) Confidence 0.81 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.70 Pain Relevance 0.11
Dipyridamole-induced myocardial ischaemia increases ANF release in man.
Localization (release) of ANF associated with coronary artery disease
3) Confidence 0.81 Published 1991 Journal Eur. Heart J. Section Title Doc Link 1830552 Disease Relevance 0.63 Pain Relevance 0.10
The aim of this study was to assess whether dipyridamole infusion (up to 0.84 mg kg-1 over 10') can affect ANF release in man.
Localization (release) of ANF
4) Confidence 0.81 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.51 Pain Relevance 0.09
Atrial natriuretic factor (ANF) release is modulated by several haemodynamic factors, including ventricular and atrial wall stretch.
Localization (release) of Atrial natriuretic factor in atrial wall associated with natriuresis
5) Confidence 0.81 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.40 Pain Relevance 0.06
The results do not suggest a major role for adrenoceptor-mediated ANF release in normal humans, and do not indicate that plasma ANF levels are determined by tonic inhibition or facilitation of the sympathetic nervous system.
Localization (release) of ANF in sympathetic nervous system
6) Confidence 0.81 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.13 Pain Relevance 0.20
To assess the potential role of adrenoceptor-stimulated atrial natriuretic factor (ANF) release in healthy humans, 18 volunteers, divided into groups of six, underwent experiments with infusion of incremental doses of salbutamol with and without beta-blockade with propranolol, propranolol alone, and bolus injections of clonidine before and after alpha-blockade with phentolamine, and phentolamine alone.
Localization (release) of atrial natriuretic factor associated with natriuresis and clonidine
7) Confidence 0.81 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.17 Pain Relevance 0.09
To assess the potential role of adrenoceptor-stimulated atrial natriuretic factor (ANF) release in healthy humans, 18 volunteers, divided into groups of six, underwent experiments with infusion of incremental doses of salbutamol with and without beta-blockade with propranolol, propranolol alone, and bolus injections of clonidine before and after alpha-blockade with phentolamine, and phentolamine alone.
Localization (release) of ANF associated with natriuresis and clonidine
8) Confidence 0.81 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.17 Pain Relevance 0.09
Since changes in right atrial pressure have been shown to influence ANF release, central venous pressure (CVP) was continuously measured 30 min before, during the 120 min duration of drug infusions, and for 30 min after the bolus injections of the drugs.
Localization (release) of ANF
9) Confidence 0.81 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.16 Pain Relevance 0.19
Animal data suggest that opiates, halothane anaesthesia and activation of the sympathetic system stimulates release of atrial natriuretic peptide (ANP).
Localization (release) of ANP in sympathetic associated with natriuresis, halothane and opiate
10) Confidence 0.78 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2964965 Disease Relevance 0.17 Pain Relevance 0.33
To evaluate to what extent opioid secretion in exercise induces the release of atrial natriuretic factor (ANF), six healthy male volunteers who were trained subjects, were submitted to two maximal exercise tests with and without (control) opioid receptor blockade by Naltrexone.
Localization (release) of atrial natriuretic factor associated with natriuresis, opioid receptor and opioid
11) Confidence 0.78 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2555188 Disease Relevance 0.25 Pain Relevance 0.22
These data demonstrate that: (1) ANF secretion during exercise is influenced by the level of beta-endorphin in the plasma; (2) the possible inhibitory role of ANF on aldosterone secretion during exercise is probably over-ruled by the increase in plasma ACTH and PRA.
Localization (secretion) of ANF in plasma
12) Confidence 0.78 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2555188 Disease Relevance 0.29 Pain Relevance 0.16
To evaluate to what extent opioid secretion in exercise induces the release of atrial natriuretic factor (ANF), six healthy male volunteers who were trained subjects, were submitted to two maximal exercise tests with and without (control) opioid receptor blockade by Naltrexone.
Localization (release) of ANF associated with natriuresis, opioid receptor and opioid
13) Confidence 0.78 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2555188 Disease Relevance 0.25 Pain Relevance 0.22
These results imply that ANP may be released in response to right heart volume overload caused by the left-to right shunt in patients with ASD.
Localization (released) of ANP in heart associated with cv general 2 under development
14) Confidence 0.73 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.88 Pain Relevance 0
In conclusion, ANP attenuates ischemic ST-segment depression and lactate release during pacing-induced myocardial ischemia in patients with CAD.
Localization (release) of ANP associated with coronary artery disease, depression and ischemia
15) Confidence 0.71 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 9972741 Disease Relevance 1.38 Pain Relevance 0.60
The induction of myocardial ischaemia acutely increases ANF release, probably through a rise in ventricular and atrial wall stress.
Localization (release) of ANF in atrial wall associated with stress and coronary artery disease
16) Confidence 0.71 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.73 Pain Relevance 0.10
Significance of adrenoceptor-mediated atrial natriuretic factor release in normal humans.
Localization (release) of atrial natriuretic factor associated with natriuresis
17) Confidence 0.71 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Title Doc Link 1850546 Disease Relevance 0.20 Pain Relevance 0.18
This effect was attributed to the hemodynamic changes of exercise which could increase atrial volume and result in ANP secretion.
Localization (secretion) of ANP
18) Confidence 0.70 Published 1989 Journal Pathol. Biol. Section Abstract Doc Link 2561015 Disease Relevance 0.23 Pain Relevance 0.43
To evaluate to what extent the endogenous opioid secretion during exercise induces the ANP release, six healthy volunteers male trained subjects were submitted to two maximal exercise tests with and without (placebo) opiate receptors blockade by naltrexone (50 mg per os).
Localization (release) of ANP associated with endogenous opioid and opiate
19) Confidence 0.70 Published 1989 Journal Pathol. Biol. Section Abstract Doc Link 2561015 Disease Relevance 0.24 Pain Relevance 0.46
The stimulation of chloride secretion in Fundulus heteroclitus chloride cells by ANF may have a role in teleost ion regulation.
Localization (secretion) of ANF
20) Confidence 0.70 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2827529 Disease Relevance 0 Pain Relevance 0.12

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