INT7133

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 85
Total Number 87
Disease Relevance 29.22
Pain Relevance 33.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
plasma 3
epithelium 3
rectum 2
Carotid body 2
neural 2
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 172 100.00 Very High Very High Very High
qutenza 22 100.00 Very High Very High Very High
Pain 27 99.92 Very High Very High Very High
Potency 17 99.92 Very High Very High Very High
corticosteroid 1 99.88 Very High Very High Very High
dexamethasone 3 99.84 Very High Very High Very High
Analgesic 13 99.70 Very High Very High Very High
Dopamine 216 99.68 Very High Very High Very High
Inflammation 32 99.68 Very High Very High Very High
nociceptor 2 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Cancer 429 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 20 99.92 Very High Very High Very High
Prostate Cancer 44 99.70 Very High Very High Very High
Cancer 816 99.68 Very High Very High Very High
INFLAMMATION 28 99.68 Very High Very High Very High
Neurogenic Inflammation 15 99.44 Very High Very High Very High
Cholecystitis 6 99.40 Very High Very High Very High
Nociception 10 99.00 Very High Very High Very High
Gallbladder Disease 21 98.90 Very High Very High Very High
Cough 15 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have studied the effects of acetorphan, an inhibitor of enkephalinase, on the electrical activity of human rectum.
Negative_regulation (inhibitor) of enkephalinase in rectum
1) Confidence 0.59 Published 1989 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 2591688 Disease Relevance 0.08 Pain Relevance 0.03
Non-cholinergic neural excitation of the human rectum induced by acetorphan, an inhibitor of enkephalinase.
Negative_regulation (inhibitor) of enkephalinase in rectum associated with analgesic
2) Confidence 0.59 Published 1989 Journal Gastroenterol. Clin. Biol. Section Title Doc Link 2591688 Disease Relevance 0.08 Pain Relevance 0.23
Of the three drugs tested thiorphan proved to be the most potent "enkephalinase" inhibitor in both plasma and CSF.
Negative_regulation (inhibitor) of enkephalinase in plasma
3) Confidence 0.58 Published 1986 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3028074 Disease Relevance 0 Pain Relevance 0.13
It is suggested that acetorphan, by reducing the degradation of endogenous enkephalins in the inflamed gall bladder, decreases fluid secretion by the epithelium and that enkephalinase inhibitors may find clinical applications in acute cholecystitis.
Negative_regulation (inhibitors) of enkephalinase in epithelium associated with gallbladder disease, enkephalin and acute cholecystitis
4) Confidence 0.58 Published 1989 Journal Clin. Sci. Section Abstract Doc Link 2758762 Disease Relevance 0.81 Pain Relevance 0.47
Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammation.
Negative_regulation (Inhibition) of neutral endopeptidase associated with inflammation and neurogenic inflammation
5) Confidence 0.58 Published 2005 Journal Exp. Neurol. Section Title Doc Link 15963503 Disease Relevance 0.47 Pain Relevance 0.32
Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammation.
Negative_regulation (Inhibition) of NEP associated with inflammation and neurogenic inflammation
6) Confidence 0.58 Published 2005 Journal Exp. Neurol. Section Title Doc Link 15963503 Disease Relevance 0.47 Pain Relevance 0.32
Antioxidant vitamin E and C treatment significantly reduced NEP enzyme activity after fatty acid exposure (P < 0.05).
Negative_regulation (reduced) of NEP enzyme
7) Confidence 0.58 Published 2003 Journal Shock Section Abstract Doc Link 12785004 Disease Relevance 0.83 Pain Relevance 0.09
We report here that a structure related to CD10/NEP is expressed by M. edulis haemocytes and that abrogation of CD10/NEP enzymatic activity reduces the amount of Met-enkephalin required for haemocyte activation by five orders of magnitude.
Negative_regulation (abrogation) of CD10 in haemocyte associated with enkephalin
8) Confidence 0.57 Published 1990 Journal Nature Section Abstract Doc Link 1699130 Disease Relevance 0.24 Pain Relevance 0.64
Potential therapeutic rationale involving the utilization of novel inhibitors of carboxypeptidase A (enkephalinase) which raise endogenous enkephalin levels and possess anti-alcohol seeking effects is emphasized.
Negative_regulation (inhibitors) of enkephalinase associated with enkephalin and alcohol
9) Confidence 0.56 Published 1985-1986 Journal Alcohol Drug Res Section Abstract Doc Link 3015159 Disease Relevance 0.18 Pain Relevance 0.42
Thiorphan, the potent inhibitor of 'enkephalinase', has shown some analgesic properties in experimental animals and in man.
Negative_regulation (inhibitor) of enkephalinase associated with analgesic
10) Confidence 0.55 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3015640 Disease Relevance 0 Pain Relevance 0.10
In lower MENK concentrations, where MENK alone had no effect on O2- release, inhibition of enkephalinase by thiorphan significantly increased O2- production, while in higher concentrations, where MENK alone was effective, inhibition of enkephalinase had no effect.
Negative_regulation (inhibition) of enkephalinase associated with enkephalin
11) Confidence 0.54 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.19
This study was designed to evaluate the ability of putative "enkephalinase" inhibitors, D-phenylalanine, captopril and thiorphan to decrease "enkephalinase" activity (EKA) in plasma and CSF in human sufferers.
Negative_regulation (decrease) of enkephalinase in plasma
12) Confidence 0.51 Published 1986 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3028074 Disease Relevance 0 Pain Relevance 0.13
On the contrary, cord blood enkephalinase activity was lower than in adult subjects and further decreased during the first hours of life.
Negative_regulation (decreased) of enkephalinase in blood
13) Confidence 0.50 Published 1986 Journal Biol Res Pregnancy Perinatol Section Abstract Doc Link 3524698 Disease Relevance 0.08 Pain Relevance 0.78
The potency of their effectiveness as analgesics or potentiators parallels their potency as inhibitors of mouse brain enkephalinase.
Negative_regulation (inhibitors) of brain enkephalinase in brain associated with analgesic and potency
14) Confidence 0.49 Published 1985 Journal Acupunct Electrother Res Section Abstract Doc Link 2866674 Disease Relevance 0.18 Pain Relevance 0.94
Inhibitors of ECE and NEP may have important therapeutic applications in cardiovascular and renal medicine.
Negative_regulation (Inhibitors) of NEP
15) Confidence 0.47 Published 1997 Journal FASEB J. Section Abstract Doc Link 9141502 Disease Relevance 0.24 Pain Relevance 0.08
Enkephalinase inhibitor potentiates substance P- and capsaicin-induced bronchial smooth muscle contractions in humans.
Negative_regulation (inhibitor) of Enkephalinase in smooth muscle associated with qutenza and substance p
16) Confidence 0.43 Published 1991 Journal Am. Rev. Respir. Dis. Section Title Doc Link 1710881 Disease Relevance 0 Pain Relevance 0.68
Effects of an enkephalinase inhibitor on esophageal motility in man.
Negative_regulation (inhibitor) of enkephalinase associated with enkephalin
17) Confidence 0.43 Published 1988 Journal Gastroenterol. Clin. Biol. Section Title Doc Link 3220232 Disease Relevance 0 Pain Relevance 0.49
Acetorphan an enkephalinase inhibitor, is able to reproduce the effect of IV exogenous enkephalins on LES relaxation in man.
Negative_regulation (inhibitor) of enkephalinase in LES associated with enkephalin
18) Confidence 0.43 Published 1988 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 3220232 Disease Relevance 0 Pain Relevance 0.34
Analgesic properties of enkephalinase inhibitors: animal and human studies.
Negative_regulation (inhibitors) of enkephalinase associated with analgesic
19) Confidence 0.43 Published 1985 Journal Prog. Clin. Biol. Res. Section Title Doc Link 2934746 Disease Relevance 0 Pain Relevance 0.89
It thus seems that both tachykinins and opioids are involved in the responses observed after neprilysin inhibition in human sperm without ruling out the possible involvement of other peptide substrates.
Negative_regulation (inhibition) of neprilysin in sperm associated with opioid
20) Confidence 0.43 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.07 Pain Relevance 0.56

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