INT7134

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Context Info
Confidence 0.79
First Reported 1987
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 127
Total Number 127
Disease Relevance 65.73
Pain Relevance 67.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
plasma 6
nerve 5
nociceptors 4
platelet 3
skin 3
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 929 100.00 Very High Very High Very High
Inflammation 834 100.00 Very High Very High Very High
Pain 536 100.00 Very High Very High Very High
Nicotine 393 100.00 Very High Very High Very High
antagonist 228 100.00 Very High Very High Very High
cytokine 208 100.00 Very High Very High Very High
b2 receptor 160 100.00 Very High Very High Very High
Hyperalgesia 153 100.00 Very High Very High Very High
qutenza 142 100.00 Very High Very High Very High
substance P 106 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 918 100.00 Very High Very High Very High
Pain 513 100.00 Very High Very High Very High
Hyperalgesia 206 100.00 Very High Very High Very High
Hypersensitivity 99 100.00 Very High Very High Very High
Injury 99 100.00 Very High Very High Very High
Nicotine Addiction 65 100.00 Very High Very High Very High
Cv Unclassified Under Development 59 100.00 Very High Very High Very High
Natriuresis 13 100.00 Very High Very High Very High
Inflammatory Pain 24 99.96 Very High Very High Very High
Skin Cancer 9 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bradykinin receptors localized by quantitative autoradiography in kidney, ureter, and bladder.
Localization (localized) of Bradykinin in kidney associated with bradykinin
1) Confidence 0.79 Published 1989 Journal Am. J. Physiol. Section Title Doc Link 2541629 Disease Relevance 0.07 Pain Relevance 0.34
Bradykinin and kallidin are released during dermal injury and inflammation as a result of activation of kallikreins which cleave high- and low-molecular weight kininogen (HMW and LMW kininogen, respectively).
Localization (released) of Bradykinin associated with inflammation, injury and bradykinin
2) Confidence 0.78 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10596865 Disease Relevance 0.69 Pain Relevance 0.24
The authors explain kallikrein action as the release of endogenous bradykinin, which subsequently releases two epithelial mediators, i.e.
Localization (release) of bradykinin associated with bradykinin
3) Confidence 0.78 Published 1991 Journal Pol Tyg Lek Section Abstract Doc Link 1669140 Disease Relevance 0.32 Pain Relevance 0.22
This was explained by bradykinin released by the venom blocking the dopaminergic receptors.
Localization (released) of bradykinin associated with bradykinin
4) Confidence 0.78 Published 1990 Journal Toxicon Section Abstract Doc Link 2087694 Disease Relevance 0.79 Pain Relevance 0.19
The biochemical mechanism of pain is based on peripheral nociceptors that preferentially receive noxious stimuli and thereafter cause the primary afferent nociceptor fibers to release endogenous chemicals such as bradykinin, histamine, prostaglandins, serotonin, norepinephrine, and substance P.
Localization (release) of bradykinin in nociceptors associated with pain, nociceptor, serotonin, bradykinin and substance p
5) Confidence 0.78 Published 1996 Journal Am. J. Med. Section Abstract Doc Link 8764761 Disease Relevance 0.86 Pain Relevance 1.25
This could be anticipated based on the fact that in both forms angioedema is mediated by bradykinin episodically released by inappropriate activation of the contact-kinin system lacking its major physiologic regulator C1-INH [6,7].
Localization (released) of bradykinin associated with pressure and volume under development and bradykinin
6) Confidence 0.78 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2925362 Disease Relevance 1.37 Pain Relevance 0.12
Contribution of bradykinin to heat-induced substance P release in the hind instep of rats.
Localization (release) of bradykinin associated with bradykinin and substance p
7) Confidence 0.74 Published 1995 Journal Life Sci. Section Title Doc Link 7536881 Disease Relevance 0.17 Pain Relevance 0.62
Morphological data: autoradiography revealed that bradykinin receptors were localized in the stratum basale of the epidermis.
Localization (localized) of bradykinin in epidermis associated with bradykinin
8) Confidence 0.73 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7498312 Disease Relevance 0.15 Pain Relevance 0.80
Autoradiographic localization and characterization of bradykinin receptors in human skin.
Localization (localization) of bradykinin in skin associated with bradykinin
9) Confidence 0.73 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 7498312 Disease Relevance 0 Pain Relevance 0.59
In this study we demonstrate that binding of HK to glycosaminoglycans (GAGs) of the heparan and chondroitin sulfate type efficiently interferes with bradykinin release in plasma and on endothelial surfaces.
Localization (release) of bradykinin in plasma associated with bradykinin
10) Confidence 0.73 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16116231 Disease Relevance 0.29 Pain Relevance 0.51
Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor.
Localization (localization) of bradykinin associated with b2 receptor
11) Confidence 0.73 Published 1994 Journal Genomics Section Title Doc Link 7835885 Disease Relevance 0.28 Pain Relevance 0.42
Because of structural similarity ACE also degrades other peptides that are substrates to this enzyme such as P substance, enkephalins, neurotensin, takynine and kininogen, the latter responsible for bradykinin generation.
Localization (generation) of bradykinin associated with enkephalin and bradykinin
12) Confidence 0.73 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 0.06 Pain Relevance 0.23
The ability of arachidonic acid (AA) and bradykinin to release calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from capsaicin-sensitive primary afferents was studied in guinea pig isolated and perfused heart.
Localization (release) of bradykinin in heart associated with qutenza, bradykinin and calcitonin gene-related peptide
13) Confidence 0.71 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1941623 Disease Relevance 0.05 Pain Relevance 0.64
BACKGROUND: Bradykinin is released by the ischemic myocardium and may be involved in the genesis of ischemic pain.
Localization (released) of Bradykinin in myocardium
14) Confidence 0.70 Published 1999 Journal J. Am. Coll. Cardiol. Section Body Doc Link 10400014 Disease Relevance 0.10 Pain Relevance 0
Pain and hyperalgesia, the perceptual campanions of tissue injury and inflammation, are thought to be in part attributable to the sensitization of primary afferent nociceptors by endogenously released chemicals, such as bradykinin.
Localization (released) of bradykinin in nociceptors associated with pain, hyperalgesia, inflammation, nociceptor, injury and bradykinin
15) Confidence 0.70 Published 1991 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 1752117 Disease Relevance 1.15 Pain Relevance 1.19
In the present proteomic profiling study, the significant reduced excretion of CD59, kininogen-1 and a 39 kDa fragment of ITIH4, and the enhanced levels of a 19 kDa fragment of albumin were detected in the urine samples of patients with ovarian carcinoma relative to those of the control subjects.
Localization (excretion) of kininogen-1 in urine associated with ovarian cancer
16) Confidence 0.68 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.51 Pain Relevance 0
Here, we have investigated the effects of bradykinin on the release of prostaglandin E(2) from cultured neurones derived from adult rat trigeminal ganglia.
Localization (release) of bradykinin in trigeminal ganglia associated with bradykinin
17) Confidence 0.68 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12782182 Disease Relevance 0.27 Pain Relevance 0.58
The venom contains a number of protein and nonprotein components including serotonin, a bradykinin-releasing substance, protease, hyaluronidase, helodermin, and gilatoxin.
Localization (releasing) of bradykinin associated with bradykinin and serotonin
18) Confidence 0.68 Published 1997 Journal Wilderness Environ Med Section Abstract Doc Link 11990142 Disease Relevance 1.54 Pain Relevance 0.39
The authors explain kallikrein action as the release of endogenous bradykinin, which subsequently releases two epithelial mediators, i.e.
Localization (releases) of bradykinin associated with bradykinin
19) Confidence 0.68 Published 1991 Journal Pol Tyg Lek Section Abstract Doc Link 1669140 Disease Relevance 0.31 Pain Relevance 0.22
Acquired angioedema

Acquired angioedema (AAE) is characterized by acquired deficiency of C1 inhibitor (C1-INH), hyperactivation of the classical pathway of human complement and angioedema symptoms mediated by bradykinin released by inappropriate activation of the contact-kinin system.

Localization (released) of bradykinin associated with pressure and volume under development and bradykinin
20) Confidence 0.68 Published 2010 Journal Allergy Asthma Clin Immunol Section Title Doc Link PMC2925362 Disease Relevance 1.52 Pain Relevance 0.21

General Comments

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