INT71349

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.70
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp21a1)
Cyp21a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 1 98.60 Very High Very High Very High
Sciatic nerve 2 95.88 Very High Very High Very High
Neuropathic pain 2 94.44 High High
Pain 10 93.96 High High
anesthesia 2 82.56 Quite High
Pain threshold 24 82.36 Quite High
Morphine 2 65.36 Quite High
Antinociceptive 2 64.60 Quite High
Hyperalgesia 2 63.08 Quite High
Opioid 2 59.80 Quite High
Disease Link Frequency Relevance Heat
Stress 48 97.16 Very High Very High Very High
Neuropathic Pain 2 94.44 High High
Pain 34 93.96 High High
Body Weight 28 88.92 High High
Nociception 24 81.00 Quite High
Injury 5 79.96 Quite High
Cancer 2 76.76 Quite High
Disease 2 75.56 Quite High
Hyperalgesia 2 63.08 Quite High
Obesity 24 50.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, it has been reported that genistein and daidzein decreased cortisol synthesis by suppressing the activity of P450c21 in cultured adrenal cortical cells [12].
Negative_regulation (suppressing) of P450c21
1) Confidence 0.42 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1276816 Disease Relevance 0.85 Pain Relevance 0.23
It was reported that genistein and daidzein decrease cortisol synthesis by suppressing the activity of P450c21 in cultured adrenal cortical cells [12], our data showed similar post-stress corticosterone levels between Phyto-600 and Phyto-free fed OVX female rats.
Negative_regulation (suppressing) of P450c21 associated with stress
2) Confidence 0.42 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1276816 Disease Relevance 0.55 Pain Relevance 0.55
FK-506 non-competitively inhibited the aniline p-hydroxylase, p-nitroanisole O-demethylase and lidocaine N-deethylase activities of cytochrome P-450-linked monooxygenase systems, these activities being mainly catalyzed by cytochromes P-450 CYP2E1, CYP2C11 and CYP3A4, respectively, and the Ki values of the activities for FK-506 were determined to be 605, 491 and 97 microM, respectively.
Negative_regulation (inhibited) of aniline p-hydroxylase associated with lidocaine
3) Confidence 0.06 Published 1997 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 9304807 Disease Relevance 0 Pain Relevance 0.10
Hepatic microsomal CYP 450 content and aniline p-hydroxylase (CYP 2E1) activity were significantly decreased; decreases that were not prevented by GdCl3.
Negative_regulation (decreased) of aniline p-hydroxylase
4) Confidence 0.05 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12568358 Disease Relevance 0.30 Pain Relevance 0.16

General Comments

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