INT71362

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Context Info
Confidence 0.04
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 1.31
Pain Relevance 5.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ubqln1) nucleus (Ubqln1) protein complex (Ubqln1)
cytoplasm (Ubqln1)
Anatomy Link Frequency
shell 2
plasma 2
excitatory neurons 1
perirhinal cortex 1
Ubqln1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 911 100.00 Very High Very High Very High
Eae 55 99.78 Very High Very High Very High
Nucleus accumbens 423 99.68 Very High Very High Very High
cocaine 12 98.76 Very High Very High Very High
GABAergic 2 90.68 High High
Neurotransmitter 62 90.12 High High
Hippocampus 63 85.68 High High
addiction 6 83.16 Quite High
gABA 3 80.84 Quite High
amygdala 28 77.28 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 161 99.78 Very High Very High Very High
Diabetes Mellitus 18 96.64 Very High Very High Very High
Appetite Loss 3 83.36 Quite High
Drug Dependence 6 83.16 Quite High
Bordatella Infection 1 63.52 Quite High
Handedness 7 5.00 Very Low Very Low Very Low
Schizophrenia 7 5.00 Very Low Very Low Very Low
Dislocations 7 5.00 Very Low Very Low Very Low
Burns 7 5.00 Very Low Very Low Very Low
Amphetamine Dependence 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that DA inhibition in hypothalamic and arcuate nucleus neurons is achieved in part through the direct inhibition of excitatory neurons, probably via DA D2 receptors acting through a Gi/Go protein on K+ channels, and in part through the enhancement of GABAergic neurotransmission.
Negative_regulation (inhibition) of DA in excitatory neurons associated with dopamine and gabaergic
1) Confidence 0.04 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307104 Disease Relevance 0.06 Pain Relevance 0.72
After mifepristone treatment, DA activity diminished significantly without modifying serum prolactin levels.
Negative_regulation (diminished) of DA
2) Confidence 0.03 Published 2006 Journal Neuroendocrinology Section Body Doc Link 17090971 Disease Relevance 0 Pain Relevance 0
Similarly, because the deficits produced by DA depletion in the core were delay dependent, it is unlikely that these effects are simply due to the behavioral impact of novelty.
Negative_regulation (depletion) of DA associated with dopamine
3) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.36
It follows that attenuated DA activity should disrupt performance on tasks mediated by hippocampal-NAc circuits, and this was the finding in the current experiments.


Negative_regulation (attenuated) of DA associated with nucleus accumbens and dopamine
4) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.83
Indeed, the demonstration that DA depletion in the NAc core disrupted performance on the object identity recognition task, whereas DA denervation in the shell selectively impaired performance on the location recognition task, highlights a role for NAc DA beyond the general processing of novelty.
Negative_regulation (depletion) of DA in shell associated with nucleus accumbens and dopamine
5) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.92
Such a time-dependent lesion effect provides arguably the best evidence that DA depletion in the core does not affect encoding but instead has effects specifically on consolidation and long-term storage or retrieval processes.
Negative_regulation (depletion) of DA associated with dopamine
6) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.14 Pain Relevance 0.40
The current finding of profound deficits in novel object recognition following DA depletion in the core suggests that interactions between the perirhinal cortex and NAc contribute to consolidation of memory processes necessary to support novel object recognition.
Negative_regulation (depletion) of DA in perirhinal cortex associated with nucleus accumbens, cognitive disorder, dopamine and eae
7) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.36 Pain Relevance 0.65
Although in principle the lack of a correlation between shell DA levels and test performance could result from the limited variability in shell DA values as both lesions depleted shell DA, a role for shell per se would seem to be precluded by the absence of any overall effect on object recognition in the shell lesion group.
Negative_regulation (depleted) of DA in shell associated with cognitive disorder and dopamine
8) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0.33 Pain Relevance 0.44
However, the present study demonstrates effects more specific than those attributable to novelty processing in that there was no effect of DA depletion in either subregion on initial exploratory approach responses to the objects in the sample phases (when all the objects were novel).
Negative_regulation (depletion) of DA associated with dopamine
9) Confidence 0.01 Published 2010 Journal Behav Neurosci Section Body Doc Link PMC3002220 Disease Relevance 0 Pain Relevance 0.35
The reduction in DA efflux determined by HSCA in the current studies may result either from a decreased DAT plasma membrane expression, as suggested by in vitro [11,13] and ex vivo [14,30] studies, from a diminished DA content [64], or from both.
Negative_regulation (reduction) of DA in plasma associated with dopamine
10) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.42
Compared to controls, STZ-treated hypoinsulinemic rats display a marked reduction in striatal DA clearance [14,30] and are resistant to the behavioral effects of AMPH [12,33,34,51].
Negative_regulation (reduction) of DA associated with dopamine
11) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.42 Pain Relevance 0.32
To evaluate whether the reduction in AMPH-induced DA efflux caused by hypoinsulinemic conditions is promoted by a decrease in DAT cell surface expression, we evaluated DAT levels at the plasma membrane in striatal synaptosomes from rats made hypoinsulinemic with STZ [13].
Spec (whether) Negative_regulation (reduction) of DA in plasma associated with dopamine
12) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.21

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