INT71370

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Context Info
Confidence 0.12
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.69
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)
Ikbkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 99.12 Very High Very High Very High
narcan 2 98.00 Very High Very High Very High
Kappa opioid receptor 6 97.44 Very High Very High Very High
antagonist 1 96.16 Very High Very High Very High
cINOD 1 96.08 Very High Very High Very High
Inflammation 23 95.88 Very High Very High Very High
Arthritis 10 93.72 High High
opioid receptor 3 85.08 High High
rheumatoid arthritis 5 81.68 Quite High
psoriasis 3 79.92 Quite High
Disease Link Frequency Relevance Heat
Disease 5 96.68 Very High Very High Very High
INFLAMMATION 22 95.88 Very High Very High Very High
Autoimmune Disease 12 95.20 Very High Very High Very High
Arthritis 10 93.72 High High
Cancer 8 88.04 High High
Rheumatoid Arthritis 5 81.68 Quite High
Psoriasis 3 79.92 Quite High
Organ Transplantation 4 79.04 Quite High
Immune System Diseases 1 76.48 Quite High
Malignant Neoplastic Disease 1 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of drugs targeting the kinases p38, JNK, MEK, IKK2, JAK3, Lck, and Syk are currently undergoing clinical trials for the treatment of diseases related to inflammation and autoimmunity.
Regulation (drugs tar) of IKK2 associated with autoimmune disease, inflammation and disease
1) Confidence 0.12 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.97 Pain Relevance 0.22
Newer agents targeting the proteasome, inhibitor-kappaB kinase, and other upstream kinases involved in NF-kappaB activation have shown anticancer activity in clinical or preclinical studies.
Regulation (targeting) of inhibitor-kappaB kinase
2) Confidence 0.05 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17317814 Disease Relevance 0.59 Pain Relevance 0.14
The effects of kappa1, kappa2, and kappa3 receptor agonists were attenuated by naloxone; two kappa-opioid receptor-selective antagonists were ineffective.
Regulation (effects) of kappa2 associated with antagonist, kappa opioid receptor, narcan and agonist
3) Confidence 0.01 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307130 Disease Relevance 0 Pain Relevance 0.72

General Comments

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