INT71374

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Context Info
Confidence 0.22
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 7.49
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 3
MNC 2
monocytes 1
Il12a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 71 100.00 Very High Very High Very High
cytokine 51 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Multiple sclerosis 4 99.44 Very High Very High Very High
Peripheral nervous system 3 98.98 Very High Very High Very High
Neuritis 9 98.10 Very High Very High Very High
Central nervous system 12 97.44 Very High Very High Very High
Demyelination 1 91.76 High High
withdrawal 14 84.64 Quite High
Pain 2 80.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 99 100.00 Very High Very High Very High
Disease 21 100.00 Very High Very High Very High
Infection 8 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Multiple Sclerosis 12 99.44 Very High Very High Very High
Demyelinating Disease 5 98.32 Very High Very High Very High
Experimental Autoimmune Neuritis 9 98.10 Very High Very High Very High
Syndrome 3 89.80 High High
Periodontal Disease 132 86.80 High High
Pain 2 80.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Spec (possibly) Positive_regulation (ameliorated) of Gene_expression (production) of interleukin-12 associated with inflammation, disease and cytokine
1) Confidence 0.22 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.34 Pain Relevance 0.36
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Spec (possibly) Positive_regulation (ameliorated) of Gene_expression (production) of IL-12 associated with inflammation, disease and cytokine
2) Confidence 0.22 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.34 Pain Relevance 0.36
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Positive_regulation (cytokines) of Gene_expression (production) of IL-12 associated with inflammation, disease and cytokine
3) Confidence 0.22 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.30 Pain Relevance 0.35
Venlafaxine ameliorated the clinical symptoms of the disease possibly by suppressed production of pro-inflammatory cytokines interleukin-12 (IL-12), p40, TNF-?
Positive_regulation (cytokines) of Gene_expression (production) of interleukin-12 associated with inflammation, disease and cytokine
4) Confidence 0.22 Published 2010 Journal J Negat Results Biomed Section Body Doc Link PMC2895576 Disease Relevance 1.30 Pain Relevance 0.35
Leishmania major: interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats.
Positive_regulation (increases) of Gene_expression (levels) of interleukin-12 associated with hyperalgesia and infection
5) Confidence 0.20 Published 2009 Journal Exp. Parasitol. Section Title Doc Link 19061890 Disease Relevance 0.79 Pain Relevance 0.56
In addition, adherent cells (monocytes/macrophages) will be stimulated for 24 hours with lipopolysaccharide to induce IL-6 and IL-12 production.
Positive_regulation (induce) of Gene_expression (production) of IL-12 in macrophages
6) Confidence 0.18 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.21 Pain Relevance 0.43
To study the involvement of immunoregulatory cytokines, we induced EAN in Lewis rats by immunizing with bovine PNS myelin (BPM) and Freund's complete adjuvant. mRNA expression of the cytokines IL-1beta, IL-6, IL-10, IL-12, TNF-alpha and TNF-beta, and the cytolytic effector molecule cytolysin was examined in lymph node mononuclear cells (MNC) over the course of EAN by in situ hybridization after culture without antigen and in the presence of BPM, the myelin P2 protein, the control antigen acetylcholine receptor, or the mitogen PHA.
Positive_regulation (examined) of Gene_expression (expression) of IL-12 in MNC associated with peripheral nervous system, neuritis and cytokine
7) Confidence 0.09 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9307234 Disease Relevance 0.99 Pain Relevance 0.95
In addition, adherent cells (monocytes/macrophages) will be stimulated for 24 hours with lipopolysaccharide to induce IL-6 and IL-12 production.
Positive_regulation (induce) of in monocytes Gene_expression (production) of IL-12 in macrophages
8) Confidence 0.06 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.21 Pain Relevance 0.43

General Comments

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