INT71389

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.91
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuron 1
oral mucosa 1
KRT19 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 92.24 High High
Pain 2 86.84 High High
Bile 1 30.12 Quite Low
medulla 7 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adamantinoma 80 99.28 Very High Very High Very High
Cleidocranial Dysplasia 100 99.14 Very High Very High Very High
Injury 12 98.40 Very High Very High Very High
Sarcoma 1 98.02 Very High Very High Very High
Chordoma 1 97.56 Very High Very High Very High
Synovial Sarcoma 1 97.36 Very High Very High Very High
Cancer 98 96.00 Very High Very High Very High
Generaliased Trisomy 1 95.64 Very High Very High Very High
Metastasis 21 95.56 Very High Very High Very High
Recurrence 23 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
K19 induction is also observed in suprabasal stratified squamous epithelial cells of oral mucosa with epithelial dysplasia (Lindberg and Rheinwald 1989; for further references, see Moll 1998), but also with inflammation (Bosch et al. 1989; Moll 1993), so that K19 cannot be used as a specific marker for dysplasia in oral mucosa.
Positive_regulation (induction) of K19 in oral mucosa associated with inflammation and cleidocranial dysplasia
1) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.01 Pain Relevance 0.05
According to a study on the antibodies against a subtype of cytokeratin by Hazelbag et al, cytokeratin (CK) in AD is different from synovial sarcoma, chordoma, or epithelial sarcoma.13 Benassi et al. insisted on a correlation between OFD and AD based on their results that showed positive CK19 and negative CK8 and CK18 staining in both OFD and AD cases.12 In a cytogenetic study, both OFD and AD have trisomies on chromosomes 7, 8, and 12.4,16
Positive_regulation (positive) of CK19 associated with sarcoma, adamantinoma, cleidocranial dysplasia, synovial sarcoma, generaliased trisomy and chordoma
2) Confidence 0.22 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628088 Disease Relevance 3.05 Pain Relevance 0
Immunohistologically, a large number of the cells were reactive to neuron specific enolase (NSE) and cytokeratin CK19, and some of the cells were positive to CK8, CK13, CK20, PGP9.5 and CEA focally and slightly.
Positive_regulation (reactive) of cytokeratin CK19 in neuron
3) Confidence 0.01 Published 1997 Journal Oral Oncol. Section Abstract Doc Link 9307734 Disease Relevance 0.85 Pain Relevance 0.09

General Comments

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