INT71400

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Klra3)
Klra3 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 1 99.80 Very High Very High Very High
long-term potentiation 84 99.74 Very High Very High Very High
antagonist 11 99.32 Very High Very High Very High
Spinal cord 28 98.76 Very High Very High Very High
narcan 4 98.20 Very High Very High Very High
Calcium channel 1 98.04 Very High Very High Very High
Glutamate receptor 4 95.48 Very High Very High Very High
qutenza 8 94.44 High High
c fibre 28 93.56 High High
spinal dorsal horn 50 90.32 High High
Disease Link Frequency Relevance Heat
Pain 9 83.88 Quite High
Nociception 3 80.56 Quite High
Hyperalgesia 8 74.08 Quite High
Neuropathic Pain 3 66.20 Quite High
INFLAMMATION 2 65.36 Quite High
Overdose 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular (i.c.v.) injection of NK1, NK2 or NK3 receptor antagonists (15-500 pmol/site), all produced significant and dose-dependent inhibition of both phases of the formalin and capsaicin tests.
Positive_regulation (injection) of NK2 associated with qutenza, antagonist and intracerebroventricular
1) Confidence 0.42 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9308027 Disease Relevance 0.23 Pain Relevance 1.23
Induction of LTP requires co-activation of neurokinin 1 (NK1) and neurokinin 2 (NK2) receptors [4], opening of T-type voltage-gated calcium channels [8,13], and activation of group I metabotropic glutamate receptors [34].
Positive_regulation (activation) of NK2 associated with glutamate receptor, calcium channel and long-term potentiation
2) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.49 Pain Relevance 1.51

General Comments

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