INT71417

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 0.23
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES2) catabolic process (CES2)
Anatomy Link Frequency
liver 2
Mast cells 1
CES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 17 99.32 Very High Very High Very High
algil 3 96.12 Very High Very High Very High
alcohol 6 95.24 Very High Very High Very High
Inflammatory response 1 88.56 High High
Morphine 1 84.00 Quite High
cytokine 14 77.92 Quite High
Inflammation 2 62.24 Quite High
Calcium channel 12 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 88.56 High High
Hypersensitivity 1 83.60 Quite High
Sprains And Strains 7 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Fibromyalgia 4 5.00 Very Low Very Low Very Low
Heart Disease 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Charcot Marie Tooth Disease 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mast cells cross the dividing line between innate and acquired immune responses because of the presence of membrane-bound, polyclonal, antigen-specific IgE, which mediates degranulation via antigen recognition [37].
IgE Binding (recognition) of in Mast cells
1) Confidence 0.47 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.23 Pain Relevance 0.15
The hCE-1 and hCE-2 bound both drugs, with Ki values in the 0.4- to 1.3-mM range.
hCE-2 Binding (bound) of
2) Confidence 0.39 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10381793 Disease Relevance 0 Pain Relevance 0.22
The hCE-1 and hCE-2 bound both drugs, with Ki values in the 0.4- to 1.3-mM range.
hCE-1 Binding (bound) of
3) Confidence 0.39 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10381793 Disease Relevance 0 Pain Relevance 0.22
These results strongly suggest that there are three CES2 'like' genes which are 92 kb apart on opossum chromosome 1; a CES6 'like' gene, which is 44 kb closer to the pter region than the CES2 gene complex; and a CES1 'like' gene, which is further upstream on chromosome one (Figure 3).
CES2 gene Binding (complex) of
4) Confidence 0.37 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The latter sequences were predicted from BLAT studies [38,39] using the opossum CES2.1 sequence to interrogate the opossum genome but corrected following alignment with the CES2.2 (GenBank: EU019538) and CES2.3 (GenBank: EU019539) sequences.
CES2 Binding (alignment) of
5) Confidence 0.32 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
The latter sequences were predicted from BLAT studies [38,39] using the opossum CES2.1 sequence to interrogate the opossum genome but corrected following alignment with the CES2.2 (GenBank: EU019538) and CES2.3 (GenBank: EU019539) sequences.
CES2.2 Binding (alignment) of
6) Confidence 0.32 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1.
hCE-1 Binding (Binding) of in liver
7) Confidence 0.30 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10381793 Disease Relevance 0 Pain Relevance 0.21
Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs.
hCE-1 Binding (binding) of in liver associated with cocaine
8) Confidence 0.06 Published 1997 Journal Drug Metab. Dispos. Section Title Doc Link 9311626 Disease Relevance 0 Pain Relevance 0.51

General Comments

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