INT71418

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 29.78
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES1)
Anatomy Link Frequency
blood 2
liver 1
platelets 1
internal 1
neck 1
CES1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cervicogenic headache 34 100.00 Very High Very High Very High
cocaine 16 99.32 Very High Very High Very High
agonist 3 98.18 Very High Very High Very High
antagonist 1 98.16 Very High Very High Very High
Angina 14 96.92 Very High Very High Very High
Pain 50 96.20 Very High Very High Very High
Dismenorea 1 91.40 High High
headache 22 86.24 High High
Morphine 1 84.00 Quite High
depression 121 75.92 Quite High
Disease Link Frequency Relevance Heat
Post-traumatic Headache 34 100.00 Very High Very High Very High
Endometriosis (extended) 16 100.00 Very High Very High Very High
Coronary Artery Disease 130 99.84 Very High Very High Very High
Cardiovascular Disease 749 99.76 Very High Very High Very High
Stroke 301 99.76 Very High Very High Very High
Pressure And Volume Under Development 50 99.76 Very High Very High Very High
Pyometra 1 99.76 Very High Very High Very High
Myocardial Infarction 90 99.62 Very High Very High Very High
Nicotine Addiction 251 99.46 Very High Very High Very High
Injury 434 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SES has been associated with stroke incidence and mortality, as well as with stroke risk factors, although there is uncertainty about the extent to which these risk factors mediate the relationship between SES and stroke [40].
SES Binding (associated) of associated with stroke
1) Confidence 0.40 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 1.04 Pain Relevance 0
SES has also been associated with subclinical measures of CVD, such as carotid artery calcification and intima-media thickness, although these relationships have not been consistent across racial/ethnic groups [39].
SES Binding (associated) of in carotid artery associated with calcification and cardiovascular disease
2) Confidence 0.40 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 1.05 Pain Relevance 0
SES is strongly associated with cardiovascular disease incidence, prevalence, and mortality in developed countries and associated with most cardiovascular disease risk factors [6].
SES Binding (associated) of associated with cardiovascular disease
3) Confidence 0.40 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 0.73 Pain Relevance 0
Disparities in care that associate with neighbourhood SES could explain why these studies observed associations between neighbourhood and cardiovascular mortality and we did not.
SES Binding (associate) of
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606022 Disease Relevance 0.51 Pain Relevance 0
We then ran a model that examined the 3-way interaction between JH, SES and sex for self-rated health.


SES Spec (examined) Binding (interaction) of
5) Confidence 0.37 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2268682 Disease Relevance 0.46 Pain Relevance 0
We can only say that in our study fractures were not significantly associated with SES.
SES Binding (associated) of
6) Confidence 0.37 Published 2006 Journal BMC Pediatr Section Body Doc Link PMC1687186 Disease Relevance 0.97 Pain Relevance 0.03
The impact on the tertiary and potential quaternary structures for these opossum CES2 like enzymes remains to be determined, however it is relevant to note that human and baboon CES2 are monomers, presumably as a result of the lack of both charge clamps and the N-glycosylation site for sialic acid attachment, which contribute to subunit-subunit binding for human CES1 [43].
CES1 Binding (binding) of
7) Confidence 0.35 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
Then to specifically assess the John Henryism Hypothesis we examine two-way interactions between JH and SES and JH and Sex.
SES Binding (interactions) of
8) Confidence 0.33 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2268682 Disease Relevance 0.51 Pain Relevance 0
Proximity to traffic arteries seemed to play a less important role in determining survival after heart failure, especially after adjustment for SES.
SES Binding (adjustment) of in heart associated with myocardial infarction
9) Confidence 0.32 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290984 Disease Relevance 0.16 Pain Relevance 0
High HMSE scores were found to be associated with high scores on internal LOC and low scores on chance LOC.
HMSE Binding (associated) of in internal
10) Confidence 0.32 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19690940 Disease Relevance 0.88 Pain Relevance 0.77
The 'side door' and 'gate' sequences for human CES1 (424Val.425Met.426Phe and 551Phe, respectively), which function in facilitating the release of fatty acid and aromatic products respectively following hydrolysis of substrate [3,15,29,30], have also undergone substitutions for these key sites, involving two of three 'side door' residues (422Leu.423Ile.424Phe) and the 'gate' residue (549Met) for opossum CES1.
CES1 Binding (undergone) of
11) Confidence 0.32 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
SES is strongly associated with cardiovascular disease incidence, prevalence, and mortality in developed countries and associated with most cardiovascular disease risk factors [6].
SES Binding (associated) of associated with cardiovascular disease
12) Confidence 0.31 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 0.73 Pain Relevance 0
The magnitude of associations between neighborhood SES and CAD risk factors was assessed by Pearson correlations for continuous variables, and point biserial correlations for categorical variables.
SES Binding (associations) of associated with coronary artery disease
13) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606022 Disease Relevance 0.35 Pain Relevance 0.03
Recently, it has become evident that the SES of the neighborhood in which a patient resides also contributes to CAD outcomes, and does so above and beyond the effects of his/her personal SES [8], [9].
SES Binding (contributes) of associated with coronary artery disease
14) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606022 Disease Relevance 0.63 Pain Relevance 0.10
The 'Z-site' glycine residue, which is a site for binding cholesterol analogues in human CES1, has been substituted in the opossum CES1 sequence (355Ala) which may reflect a change in the ligand binding properties for this enzyme.
CES1 Binding (binding) of
15) Confidence 0.30 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
As has been the case in industrialized countries for the past several decades [6], low SES is associated with increased CVD morbidity and mortality among Australians overall [7,8].
SES Binding (associated) of associated with cardiovascular disease
16) Confidence 0.30 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 1.60 Pain Relevance 0
Various adjustments for smoking did not materially change associations between SES variables and self-reported CVD among either group (Table 2).
SES Neg (not) Binding (associations) of associated with nicotine addiction and cardiovascular disease
17) Confidence 0.30 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 1.11 Pain Relevance 0
Similarly, SES appears to be associated with high blood pressure, although different measures of SES have been used in different studies, places, and populations [41].
SES Binding (associated) of in blood associated with pressure and volume under development
18) Confidence 0.30 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 1.17 Pain Relevance 0
Socioeconomic status (SES) is associated with CVD, but the nature of the relationship has varied over time and place, depending in part on the stage of the CVD-related epidemiologic transition [4,6].
SES Binding (associated) of associated with cardiovascular disease
19) Confidence 0.30 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 1.80 Pain Relevance 0
In a recent US study, SES (based on a combination of income and education) was significantly associated with estimated 10-year global CVD risk in all racial/ethnic groups except foreign-born Mexican American men.
SES Binding (associated) of associated with cardiovascular disease
20) Confidence 0.30 Published 2010 Journal Popul Health Metr Section Body Doc Link PMC3006359 Disease Relevance 0.92 Pain Relevance 0

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