INT7142

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Context Info
Confidence 0.60
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 7.69
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLD) small molecule metabolic process (DLD) oxidoreductase activity (DLD)
aging (DLD) cellular nitrogen compound metabolic process (DLD) cytoplasm (DLD)
Anatomy Link Frequency
LAD 5
proximal 4
myocardium 1
brain 1
spinal 1
DLD (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 35 99.84 Very High Very High Very High
cva 8 99.84 Very High Very High Very High
mu opioid receptor 1 99.38 Very High Very High Very High
Delta opioid receptors 2 97.28 Very High Very High Very High
Neurotransmitter 3 95.76 Very High Very High Very High
antagonist 4 94.12 High High
Angina 30 93.52 High High
Spinal cord 3 93.24 High High
long-term potentiation 1 91.96 High High
Peripheral nerve injury 1 83.68 Quite High
Disease Link Frequency Relevance Heat
American Trypanosomiasis 2 99.98 Very High Very High Very High
Cv General 3 Under Development 23 99.84 Very High Very High Very High
Cv Unclassified Under Development 23 99.84 Very High Very High Very High
Nervous System Injury 2 99.84 Very High Very High Very High
Rhinitis 125 99.28 Very High Very High Very High
Congenital Anomalies 6 96.64 Very High Very High Very High
Thrombosis 6 95.84 Very High Very High Very High
Injury 10 95.52 Very High Very High Very High
Urological Neuroanatomy 28 95.12 Very High Very High Very High
Diabetes Mellitus 31 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LAD ESPLR Lo was increased by ischemia by 64% and 61% at I2, and 91% and 122% at TO, before and after diltiazem, respectively.
Positive_regulation (increased) of LAD associated with ischemia
1) Confidence 0.60 Published 1992 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1421071 Disease Relevance 0.58 Pain Relevance 0.39
[Myeloperoxidase as a factor of oxidative damage of the myocardium: inactivation of dihydrolipoamide dehydrogenase].
Positive_regulation (inactivation) of dihydrolipoamide dehydrogenase in myocardium
2) Confidence 0.49 Published 1998 Journal Medicina (B Aires) Section Title Doc Link 9706251 Disease Relevance 0.63 Pain Relevance 0
CONCLUSIONS: The %lipid and %fibrosis contents differ significantly between plaques in the proximal segment and those in the distal segment of the LAD.
Positive_regulation (distal segment) of LAD in plaques
3) Confidence 0.43 Published 2010 Journal Circ. J. Section Body Doc Link 19952436 Disease Relevance 0 Pain Relevance 0
Hamodraka et al reported an extremely unusual case of LAD continuing as posterior descending artery in posterior interventricular groove after going around the left ventricular apex in the absence of right coronary ostium – an intriguing variation on the L2 Lipton subtype, where RCA, instead of arising from proximal branches of left coronary artery arises as a distal continuation of LAD [35].
Positive_regulation (continuing) of LAD in proximal
4) Confidence 0.42 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC2104526 Disease Relevance 0.19 Pain Relevance 0
Hamodraka et al reported an extremely unusual case of LAD continuing as posterior descending artery in posterior interventricular groove after going around the left ventricular apex in the absence of right coronary ostium – an intriguing variation on the L2 Lipton subtype, where RCA, instead of arising from proximal branches of left coronary artery arises as a distal continuation of LAD [35].
Positive_regulation (unusual) of LAD in proximal
5) Confidence 0.42 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC2104526 Disease Relevance 0.19 Pain Relevance 0
Hamodraka et al reported an extremely unusual case of LAD continuing as posterior descending artery in posterior interventricular groove after going around the left ventricular apex in the absence of right coronary ostium – an intriguing variation on the L2 Lipton subtype, where RCA, instead of arising from proximal branches of left coronary artery arises as a distal continuation of LAD [35].
Positive_regulation (continuation) of LAD in proximal
6) Confidence 0.42 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC2104526 Disease Relevance 0.17 Pain Relevance 0
During atrial pacing, the rate-pressure product increased by 97%, and in the LAD area fpl increased by 46% (p < 0.05), E decreased by 6% (NS), and PS increased by 39% (NS), whereas in the CX region flow increased by only 9% (p < 0.01), E decreased by 15% (p < 0.05), and PS decreased by 15% (NS) compared with baseline values.
Positive_regulation (increased) of LAD
7) Confidence 0.41 Published 1994 Journal Cardiology Section Abstract Doc Link 7987871 Disease Relevance 0.06 Pain Relevance 0.06
The relatively low patency rate for the LAD was caused by an increased collateral flow to the occluded LAD and therefore by a significantly lower bypass flowrate measured during surgery.
Positive_regulation (increased) of LAD in LAD
8) Confidence 0.40 Published 1986 Journal Z Kardiol Section Abstract Doc Link 3493597 Disease Relevance 0.43 Pain Relevance 0.26
Coronary spasm in the LAD was induced by an intracoronary injection of 100 microg acetylcholine.
Positive_regulation (induced) of LAD in LAD associated with cva
9) Confidence 0.39 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11605774 Disease Relevance 0.93 Pain Relevance 0.21
Local stabilization for the LAD is obtained and the LIMA-to-LAD anastomosis is performed.
Positive_regulation (stabilization) of LAD in LIMA
10) Confidence 0.33 Published 1999 Journal Heart Surg Forum Section Body Doc Link 11276464 Disease Relevance 0 Pain Relevance 0
The LM, LAD, proximal and mid segments of the Cx, RDP and proximal segment of RCA showed laminar flow and normal flow velocities, without any signs of colour-aliasing suggestive of stenosis.
Positive_regulation (segments) of LAD in proximal associated with pathologic constriction
11) Confidence 0.31 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2100043 Disease Relevance 0.38 Pain Relevance 0.15
Then the increasing rate of the diastolic coronary flow velocity in the LAD was calculated.
Positive_regulation (increasing) of LAD in LAD
12) Confidence 0.23 Published 1992 Journal J Cardiol Section Abstract Doc Link 1339795 Disease Relevance 0.47 Pain Relevance 0.16
CFR measurements of the LAD in animal studies have demonstrated an increase of the mean flow velocity after sildenafil [21,11].
Positive_regulation (measurements) of LAD
13) Confidence 0.21 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC194431 Disease Relevance 0.65 Pain Relevance 0.04
Disparities between binding data and functional bioassays of [Aib3] indicated that Phe3 was required for bioactivity in mouse vas deferens but not for interaction with delta opioid receptors in rat brain membranes.
Neg (not) Positive_regulation (required) of Phe3 in brain associated with delta opioid receptors
14) Confidence 0.20 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9258365 Disease Relevance 0 Pain Relevance 0.19
The diameter of the LAD was measured in separate pigs during baseline and during reperfusion at the same angle to ensure that a change in diameter did not occur in the LAD.
Neg (not) Positive_regulation (occur) of LAD in LAD
15) Confidence 0.13 Published 2007 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1808476 Disease Relevance 0.15 Pain Relevance 0.04
The heat-injury area that contained the tumors was negative for NADH diaphorase activity.
Positive_regulation (negative) of NADH diaphorase
16) Confidence 0.12 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 18444992 Disease Relevance 0.13 Pain Relevance 0
The increase in cross-sectional area of segment 6 in the LAD as observed on orthogonal coronary angiograms was 6.0 +/- 2.0%.
Positive_regulation (increase) of LAD in LAD
17) Confidence 0.11 Published 1992 Journal J Cardiol Section Abstract Doc Link 1339814 Disease Relevance 0.32 Pain Relevance 0.08
We conclude that mu-opioid receptors contain distinct regions that accomodate the stacked phenol groups of Tyr1 and Tyr5 residues and the phenyl group of Phe3.
Positive_regulation (accomodate) of Phe3 associated with mu opioid receptor
18) Confidence 0.08 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2163014 Disease Relevance 0 Pain Relevance 0.19
Trypanosoma cruzi dihydrolipoamide dehydrogenase is inactivated by myeloperoxidase-generated "reactive species".
Positive_regulation (inactivated) of dihydrolipoamide dehydrogenase associated with american trypanosomiasis
19) Confidence 0.06 Published 2000 Journal Free Radic. Res. Section Title Doc Link 10826917 Disease Relevance 1.10 Pain Relevance 0.08
Induction of spinal NADPH-diaphorase by nerve injury is attenuated by adrenal medullary transplants.
Positive_regulation (Induction) of spinal NADPH-diaphorase in spinal associated with nervous system injury
20) Confidence 0.03 Published 1994 Journal Brain Res. Section Title Doc Link 8004464 Disease Relevance 0.61 Pain Relevance 0.52

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