INT71440

Context Info Confidence 0.32 First Reported 1997 Last Reported 1997 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.89 Pain Relevance 0.96

mitochondrion (Pars2) ligase activity (Pars2) cytoplasm (Pars2)

Anatomy Link Frequency neurons 2 Pars2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 3 98.72 Eae 8 95.16 Neuropathic pain 7 93.76 Sciatic nerve 2 93.64 Dorsal horn neuron 3 85.44 Spinal cord 4 84.64 Dorsal horn 2 77.60 intrathecal 2 58.32 Thermal hyperalgesia 1 44.16 Hyperalgesia 1 41.52

Disease Link Frequency Relevance Heat Drug Induced Neurotoxicity 3 98.08 Injury 8 95.16 Neuropathic Pain 8 93.76 Hyperalgesia 2 44.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, we examined whether the inhibition of the nitric oxide (NO)-activated poly(ADP-ribose) synthetase (PARS), a nuclear enzyme critical to glutamate-induced neurotoxicity, would both reduce the incidence of dark neurons and attenuate behavioral manifestations of neuropathic pain in CCI rats.

Spec (whether) Negative_regulation (inhibition) of Spec (whether) Positive_regulation (-activated) of PARS in neurons associated with glutamate, drug induced neurotoxicity, eae and neuropathic pain

1) Confidence 0.32 Published 1997 Journal Pain Section Abstract Doc Link 9313276 Disease Relevance 0.89 Pain Relevance 0.96

General Comments

This test has worked.