INT71441

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 5.75
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pars2) ligase activity (Pars2) cytoplasm (Pars2)
Anatomy Link Frequency
spinal cord 2
cleavage 1
nucleus 1
neural 1
neuronal 1
Pars2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 20 99.92 Very High Very High Very High
ischemia 22 99.76 Very High Very High Very High
Spinal cord 13 98.98 Very High Very High Very High
Glutamate 6 98.72 Very High Very High Very High
agonist 8 98.64 Very High Very High Very High
Dorsal horn 4 95.68 Very High Very High Very High
Eae 8 93.76 High High
Neuropathic pain 7 93.76 High High
Sciatic nerve 7 92.24 High High
Inflammatory response 1 87.04 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 29 99.92 Very High Very High Very High
Cv General 4 Under Development 1 99.76 Very High Very High Very High
Nociception 4 99.36 Very High Very High Very High
Reperfusion Injury 20 99.12 Very High Very High Very High
Drug Induced Neurotoxicity 4 98.00 Very High Very High Very High
Renal Disease 5 96.52 Very High Very High Very High
Stress 5 94.84 High High
Cv Unclassified Under Development 21 94.20 High High
Injury 14 94.20 High High
Neuropathic Pain 8 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In kidneys from control animals, histological examination revealed severe renal damage and immunohistochemical localization demonstrated PARS activation in the proximal tubule.
Positive_regulation (activation) of PARS in proximal
1) Confidence 0.69 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744621 Disease Relevance 0.50 Pain Relevance 0.13
However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage.
Positive_regulation (activation) of PARS in neuronal associated with cv general 4 under development and ischemia
2) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820212 Disease Relevance 0.60 Pain Relevance 0.23
Both renal damage and PARS activation were attenuated by administration of PARS inhibitors during reperfusion.
Positive_regulation (activation) of PARS
3) Confidence 0.60 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744621 Disease Relevance 0.49 Pain Relevance 0.13
The PARS inhibitors also significantly increased GFR and reduced FE(Na), suggesting the recovery of both glomerular and tubular function, respectively, with a more pronounced recovery of tubular function.
Positive_regulation (increased) of PARS
4) Confidence 0.50 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744621 Disease Relevance 0.58 Pain Relevance 0.15
The activation of poly (ADP-ribose) synthetase (PARS) subsequent to DNA damage caused by reactive oxygen or nitrogen species has been implicated in several pathophysiological conditions, including ischemia-reperfusion injury and shock.
Positive_regulation (activation) of PARS in poly associated with reperfusion injury, ischemia and shock
5) Confidence 0.50 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744621 Disease Relevance 0.64 Pain Relevance 0.15
Therefore, we propose that PARS activation contributes to renal reperfusion injury and that PARS inhibitors may be beneficial in renal disorders associated with oxidative stress-mediated injury.
Positive_regulation (activation) of PARS associated with stress, reperfusion injury, injury and renal disease
6) Confidence 0.46 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744621 Disease Relevance 0.70 Pain Relevance 0.10
In the present study, we examined whether the inhibition of the nitric oxide (NO)-activated poly(ADP-ribose) synthetase (PARS), a nuclear enzyme critical to glutamate-induced neurotoxicity, would both reduce the incidence of dark neurons and attenuate behavioral manifestations of neuropathic pain in CCI rats.
Spec (whether) Positive_regulation (-activated) of PARS in neurons associated with glutamate, drug induced neurotoxicity, eae and neuropathic pain
7) Confidence 0.38 Published 1997 Journal Pain Section Abstract Doc Link 9313276 Disease Relevance 0.88 Pain Relevance 0.95
Activation of protease-activated receptors (PARs) in non-neural tissue results in prostaglandin production.
Positive_regulation (Activation) of PARs in neural
8) Confidence 0.20 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15175421 Disease Relevance 0.24 Pain Relevance 0.48
PARs were activated using either thrombin or peptide agonists derived from the four PAR subtypes, delivered to the lumbar spinal cord.
Positive_regulation (activated) of PARs in spinal cord associated with agonist and spinal cord
9) Confidence 0.19 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15175421 Disease Relevance 0.27 Pain Relevance 0.68
Because PARs are found in the spinal cord and increased prostaglandin release in the spinal cord causes thermal hyperalgesia, we hypothesized that activation of these spinal PARs would stimulate prostaglandin production and cause a cyclooxygenase-dependent thermal hyperalgesia.
Positive_regulation (activation) of PARs in spinal cord associated with thermal hyperalgesia and spinal cord
10) Confidence 0.17 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15175421 Disease Relevance 0.27 Pain Relevance 0.63
Proteinase-activated receptors (PARs) are G-protein-coupled receptors that are activated by the proteolytic cleavage of their N-terminal domain.
Positive_regulation (activated) of PARs in cleavage
11) Confidence 0.07 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924448 Disease Relevance 0 Pain Relevance 0
Proteinase-activated receptors (PARs) are a family of G-protein-coupled receptors that are activated by endogenous serine proteinases that cleave the N-terminal domain of the receptor unmasking a "tethered ligand" sequence.
Positive_regulation (activated) of PARs
12) Confidence 0.04 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17921188 Disease Relevance 0.34 Pain Relevance 0.42
We have recently demonstrated (J Physiol 506 (1998) 459) that the dynamic activation of descending inhibition of the nociceptive response of spinal multireceptive cells occurs in the nucleus reticularis gigantocellularis pars alpha (GiA).
Positive_regulation (occurs) of gigantocellularis pars alpha in nucleus associated with nociception
13) Confidence 0.01 Published 2001 Journal Pain Section Abstract Doc Link 11323126 Disease Relevance 0.15 Pain Relevance 0.10

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