INT71465

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.69
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (HIST1H1B) nucleus (HIST1H1B) DNA binding (HIST1H1B)
Anatomy Link Frequency
chorion 1
amnion 1
HIST1H1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 98.44 Very High Very High Very High
Pain 12 96.20 Very High Very High Very High
antidepressant 35 92.76 High High
Serotonin 36 69.24 Quite High
depression 42 51.72 Quite High
sSRI 41 40.80 Quite Low
Dismenorea 4 35.76 Quite Low
abdominal pain 1 25.00 Low Low
Bioavailability 3 23.36 Low Low
Duloxetine 33 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 416 100.00 Very High Very High Very High
Sprains And Strains 60 100.00 Very High Very High Very High
Stroke 58 99.84 Very High Very High Very High
Immunization 43 99.82 Very High Very High Very High
Infection 26 96.84 Very High Very High Very High
Pain 14 96.20 Very High Very High Very High
Major Depressive Disorder 27 91.08 High High
Influenza In Birds 5 81.96 Quite High
Hypertension 4 80.00 Quite High
Diabetes Mellitus 7 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decidua and placenta synthesize the human relaxins, termed H1 and H2, believed to be involved in collagen remodeling in the amnion and chorion in an autocrine/paracrine manner.
Gene_expression (synthesize) of H1 in chorion
1) Confidence 0.58 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9314597 Disease Relevance 0.07 Pain Relevance 0
The decidua and placenta synthesize the human relaxins, termed H1 and H2, believed to be involved in collagen remodeling in the amnion and chorion in an autocrine/paracrine manner.
Gene_expression (synthesize) of H1 in amnion
2) Confidence 0.20 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9314597 Disease Relevance 0.07 Pain Relevance 0
1-adrenergic, and H1 receptors, whereas the activity at muscarinic and cholinergic receptors was minimal.208
Gene_expression (receptors) of H1
3) Confidence 0.18 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.42 Pain Relevance 0.11
Sub-haplogroup H1 was found to be significantly less frequent in ischemic stroke patients than in controls when comparing each clade against all others pooled together (?
Gene_expression (frequent) of H1 associated with stroke
4) Confidence 0.16 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492853 Disease Relevance 0.51 Pain Relevance 0
Strikingly, we found that the frequencies of H3-, H1-, and NP-specific CD8 cells producing cytokines (IL-2, IFN-?
Gene_expression (frequencies) of H1 associated with cytokine
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.82 Pain Relevance 0.08
Overlapping peptides were designed for three major influenza antigens included in the seasonal vaccine: i) H3, a recent strain not contained in seasonal influenza vaccines in Europe over the past five years, ii) H1, repeatedly present in influenza seasonal vaccines over the past five years, and iii) NP.
Gene_expression (designed) of H1 associated with influenza virus infection and sprains and strains
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.83 Pain Relevance 0.07
Two weeks after immunization the HAI responses to the H1 and H3 antigens of TIV were higher in those that received TIV + VAX102 than in TIV + placebo (309 vs 200 and 269 vs 185, respectively), although statistically non-significant.
Gene_expression (responses) of H1 associated with immunization
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3010987 Disease Relevance 0.55 Pain Relevance 0.10
Infected birds were the major source of the H5N1 influenza virus among humans in Asia.
Gene_expression (source) of H5N1 associated with influenza virus infection
8) Confidence 0.08 Published 2006 Journal Georgian Med News Section Abstract Doc Link 16575138 Disease Relevance 0.78 Pain Relevance 0
In humans, however, only three hemagglutinin proteins (H1, H2, and H3) and two neuraminidase proteins (N1 and N2) have been detected in epidemics and pandemics since 1900.
Gene_expression (detected) of H1
9) Confidence 0.03 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692112 Disease Relevance 0.63 Pain Relevance 0

General Comments

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