INT7147

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 16
Disease Relevance 4.42
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Vsig2) biological_process (Vsig2)
Anatomy Link Frequency
motor nerve 1
urine 1
Vsig2 (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 10 100.00 Very High Very High Very High
conotoxin 1 99.68 Very High Very High Very High
guanethidine 2 98.80 Very High Very High Very High
sodium channel 191 90.68 High High
tetrodotoxin 15 90.16 High High
Clonidine 2 82.04 Quite High
Kinase C 1 75.12 Quite High
agonist 11 70.32 Quite High
palliative 30 68.28 Quite High
imagery 24 58.56 Quite High
Disease Link Frequency Relevance Heat
Vibrio Infection 1 99.84 Very High Very High Very High
Poisoning 2170 98.24 Very High Very High Very High
Ciguatera Poisoning 540 95.44 Very High Very High Very High
Sprains And Strains 120 86.64 High High
Neuroblastoma 31 82.00 Quite High
Glioma 11 80.72 Quite High
Overactive Bladder 1 80.56 Quite High
Bordatella Infection 1 65.08 Quite High
Stupor 1 61.56 Quite High
Body Weight 42 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of these toxins accumulate in the fish tissue and can be metabolized into the different forms (e.g., CTX-1B and 51-hydroxyCTX-3C) from original CTX structures (e.g., CTX-3C and CTX-4B) that are ultimately responsible for human intoxication.
Localization (metabolized) of CTX-3C associated with poisoning
1) Confidence 0.49 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.60 Pain Relevance 0
Besides, formic acid also improved the base peak chromatogram and the MS spectrum by five-fold compared to TFA, and consequently seemed to be more adequate for CTX ionization.
Localization (ionization) of CTX
2) Confidence 0.49 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0 Pain Relevance 0
Some of these toxins accumulate in the fish tissue and can be metabolized into the different forms (e.g., CTX-1B and 51-hydroxyCTX-3C) from original CTX structures (e.g., CTX-3C and CTX-4B) that are ultimately responsible for human intoxication.
Localization (metabolized) of CTX-4B associated with poisoning
3) Confidence 0.49 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.61 Pain Relevance 0
This modified CREM not only reduced the time of preparation for fish extracts while requiring only a small quantity of fish flesh, but also showed an excellent reproducibility for P-CTX recovery from fish flesh, as well as a lower detection limit of 0.03 ng g?
Localization (recovery) of CTX
4) Confidence 0.42 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0 Pain Relevance 0
Other cell lines, including primary cell cultures, have been used to identify CTX mechanisms of action or to confirm and quantify the presence of CTX.
Localization (presence) of CTX
5) Confidence 0.42 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.25 Pain Relevance 0.08
Some of these toxins accumulate in the fish tissue and can be metabolized into the different forms (e.g., CTX-1B and 51-hydroxyCTX-3C) from original CTX structures (e.g., CTX-3C and CTX-4B) that are ultimately responsible for human intoxication.
Localization (metabolized) of CTX associated with poisoning
6) Confidence 0.42 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.60 Pain Relevance 0
Other cell lines, including primary cell cultures, have been used to identify CTX mechanisms of action or to confirm and quantify the presence of CTX.
Localization (presence) of CTX
7) Confidence 0.42 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.25 Pain Relevance 0.07
Some of these toxins accumulate in the fish tissue and can be metabolized into the different forms (e.g., CTX-1B and 51-hydroxyCTX-3C) from original CTX structures (e.g., CTX-3C and CTX-4B) that are ultimately responsible for human intoxication.
Localization (metabolized) of CTX-1B associated with poisoning
8) Confidence 0.42 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.60 Pain Relevance 0
In this communication we summarize our current knowledge concerning the mode of action of ciguatoxin (CTX) on acetylcholine (ACh) release either from motor nerve terminals or from pure cholinergic synaptosomes.
Localization (release) of CTX in motor nerve
9) Confidence 0.41 Published 1992 Journal Bull Soc Pathol Exot Section Abstract Doc Link 1340351 Disease Relevance 0 Pain Relevance 0.06
Some time (months) after the occurrence of toxic Gambierdiscus spp. blooms, the appearance of CTX-containing herbivorous fish may occur [121].
Localization (appearance) of CTX
10) Confidence 0.40 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.34 Pain Relevance 0
Recently, brevenal, a polyether compound produced by the dinoflagellate Karenia brevis, was described as a potent inhibitor of CTX-induced neurotoxic effects; acting through the inhibition of CTX-induced catecholamine secretion [63].
Localization (secretion) of CTX associated with catecholamine
11) Confidence 0.40 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.70 Pain Relevance 0.17
Moreover, the stimulatory effect of forskolin and cholera toxin (CTX) (activator of G (s)-proteins) on the secretion of insulin was markedly enhanced in the presence of emiglitate.
Localization (secretion) of CTX associated with vibrio infection
12) Confidence 0.33 Published 1996 Journal Biosci. Rep. Section Abstract Doc Link 8861537 Disease Relevance 0.16 Pain Relevance 0.23
CTX) (0.1 µM); 4,5-diaminofluorescein diacetate (DAF-2DA) (10 µM); (100 µM); guanethidine (5 µM); N-?
Localization (diacetate) of CTX associated with guanethidine
13) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659787 Disease Relevance 0.06 Pain Relevance 0.22
The values are the average of two independent measurements and deviated less than 15%.Fig. 4Cumulative release of hGH from dex-HEMA microspheres (DS 16, initial water content 50%, initial protein loading) used in the clinical study (CTM, Table II).
Localization (release) of CTM
14) Confidence 0.09 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
Figure 4 shows the release curve of the clinical trial material (CTM).
Localization (release) of CTM
15) Confidence 0.09 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
To assess age-related changes in cartilage turnover, we measured the creatinine-corrected excretion of CTX-II (for details see below) in the urine of six male and six female rats sampled at 1, 2, 3, 6.5, and 9.5 months of age.
Localization (excretion) of CTX-II in urine
16) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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