INT71477

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 1.69
Pain Relevance 5.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
neurons 2
platelets 2
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 45 100.00 Very High Very High Very High
Morphine 17 100.00 Very High Very High Very High
Intracerebroventricular 1 99.80 Very High Very High Very High
Nav1.1 3 99.62 Very High Very High Very High
nMDA receptor antagonist 2 99.06 Very High Very High Very High
Glutamate 38 98.96 Very High Very High Very High
Antinociceptive 5 98.36 Very High Very High Very High
antagonist 48 97.80 Very High Very High Very High
tolerance 17 97.72 Very High Very High Very High
Dopamine 139 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 28 99.64 Very High Very High Very High
Congenital Anomalies 8 99.18 Very High Very High Very High
Toxicity 1 97.84 Very High Very High Very High
Anxiety Disorder 91 94.72 High High
Depression 3 82.44 Quite High
Neuropathic Pain 26 77.72 Quite High
Pain 108 75.00 Quite High
Opiate Addiction 2 75.00 Quite High
Cognitive Disorder 3 68.76 Quite High
Aging 1 55.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that intracerebroventricular (i.c.v.) injection of either a PKC or PKA inhibitor completely reversed the expression of 5- to 8-fold morphine antinociceptive tolerance.
Negative_regulation (reversed) of Positive_regulation (injection) of PKA associated with tolerance, antinociceptive, intracerebroventricular and morphine
1) Confidence 0.37 Published 2003 Journal Brain Res. Section Abstract Doc Link 12957370 Disease Relevance 0 Pain Relevance 0.97
Moreover, the residual persistent currents in these mutant neurons-which are attributable to Nav1.1/1.2 channels-were reduced significantly by PKA activation.
Negative_regulation (reduced) of Positive_regulation (activation) of PKA in neurons associated with nav1.1
2) Confidence 0.29 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11264302 Disease Relevance 0 Pain Relevance 0.79
This suggests that inhibition of the spontaneous augmentation of NaV1.9 by PKA activation was not due to the hyperpolarizing shift of the h?
Negative_regulation (inhibition) of Positive_regulation (activation) of PKA
3) Confidence 0.25 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0 Pain Relevance 0.03
These results indicate that the spontaneous augmentation of NaV1.9 is suppressed by activation of PKA.
Negative_regulation (suppressed) of Positive_regulation (activation) of PKA
4) Confidence 0.25 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0 Pain Relevance 0
Thus, model simulations suggest that PKA activation, phosphorylation of DARPP-32 at Thr34, and subsequent PP1 inhibition, produced by conjunctive glutamate and D1 receptor stimulation, can produce LTP by increased phosphorylation of AMPA receptors.
Negative_regulation (inhibition) of Positive_regulation (activation) of PKA associated with glutamate and long-term potentiation
5) Confidence 0.23 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.75
In addition, the hippocampal slices of Ng knockout mice displayed a reduced activation of Ca2+/CaM-dependent kinase II (CaMKII) and PKC isozymes, as well as PKA.
Negative_regulation (reduced) of Positive_regulation (activation) of PKA associated with targeted disruption and kinase c
6) Confidence 0.11 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.57 Pain Relevance 0.41
CREB antisense oligonucleotide infusions completely blocked the morphine-induced upregulation of type VIII adenylyl cyclase but not of PKA.
Negative_regulation (blocked) of Positive_regulation (upregulation) of PKA associated with morphine
7) Confidence 0.10 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9315909 Disease Relevance 0.22 Pain Relevance 1.16
Pretreatment with a selective calcium-permeable AMPA/KA receptor antagonist (5nmol joro spider toxin), but not an NMDA receptor antagonist (25nmol d-2-amino-5-phosphonovalerate, AP-5), blocked thermal stimulus-evoked increases in phosphorylated PKA and PKC, in addition to increased cytosolic GLUR1.
Negative_regulation (blocked) of Positive_regulation (increases) of PKA associated with nmda receptor antagonist and antagonist
8) Confidence 0.07 Published 2005 Journal Pain Section Abstract Doc Link 16150547 Disease Relevance 0.34 Pain Relevance 0.59
As a consistent model, we propose in Meta II an orientation of the 15-anti Schiff base toward the cytoplasmic side of the receptor, away from Glu181, resulting in a low apparent pKA, while the 15-syn Schiff base in active Meta III is oriented toward Glu181, thereby increasing the apparent pKA considerably.
Negative_regulation (oriented) of Positive_regulation (increasing) of pKA
9) Confidence 0.07 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
-AR mediated rise in cAMP production, it remained unclear whether phosphorylation of ERK was dependent upon this cAMP-dependent activation of PKA.
Spec (whether) Negative_regulation (dependent) of Spec (whether) Positive_regulation (activation) of PKA
10) Confidence 0.06 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.05 Pain Relevance 0.03
Disruption of phosphorylation at potential PKA phosphorylationsite S116D (replacing serine (S) residue with alanine (A)) [16, 137] prevented desensitization.
Negative_regulation (prevented) of Positive_regulation (potential) of PKA
11) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.06 Pain Relevance 0.47
Abnormalities in the PKA have also been reported with decreased c-AMP-stimulated PKA activity (Perez et al 2000) and a reduced phosphorylation state of the PKA substrate Rap1 (Tardito et al 2001) in the platelets of OCD patients.
Negative_regulation (decreased) of Positive_regulation (stimulated) of PKA in platelets associated with congenital anomalies and anxiety disorder
12) Confidence 0.02 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.44 Pain Relevance 0.37

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