INT71478

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 5.14
Pain Relevance 8.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
nerve 2
neurons 2
nociceptors 2
PGE2 2
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 116 100.00 Very High Very High Very High
Kinase C 61 100.00 Very High Very High Very High
qutenza 24 100.00 Very High Very High Very High
bDMF 20 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
nociceptor 46 99.98 Very High Very High Very High
Glutamate 103 99.96 Very High Very High Very High
Sciatic nerve 4 99.84 Very High Very High Very High
Dopamine 361 99.56 Very High Very High Very High
gABA 5 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 125 98.92 Very High Very High Very High
Opiate Addiction 5 97.82 Very High Very High Very High
Toxicity 1 97.36 Very High Very High Very High
Neuropathic Pain 29 96.28 Very High Very High Very High
INFLAMMATION 155 94.24 High High
Obesity 51 92.08 High High
Urological Neuroanatomy 6 91.84 High High
Alzheimer's Dementia 38 88.00 High High
Infection 3 85.92 High High
Depression 79 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When a fast calcium pulse (as illustrated in Figure 4B1) is given with each dopamine elevation, as would happen with simultaneous release from the glutamatergic and dopaminergic terminals, the activation of PKA is greatly enhanced compared with the response to dopamine alone.
Positive_regulation (enhanced) of Positive_regulation (activation) of PKA associated with dopamine
1) Confidence 0.37 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.32
Possible involvement of PKA and PKC pathways in the voltage dependence of inactivation for the NaV1.9 current
Positive_regulation (pathways) of Spec (Possible) Positive_regulation (involvement) of PKA associated with addiction
2) Confidence 0.29 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0 Pain Relevance 0.14
When transient calcium and dopamine stimuli were paired, PKA activation and Thr34 phosphorylation increased compared with dopamine alone.
Positive_regulation (increased) of Positive_regulation (activation) of PKA associated with dopamine
3) Confidence 0.25 Published 2006 Journal PLoS Computational Biology Section Abstract Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.39
This suggests that the cellular mechanisms leading to temporal difference learning is the enhanced stimulation of PKA with paired calcium and dopamine stimuli.
Positive_regulation (enhanced) of Positive_regulation (stimulation) of PKA associated with dopamine
4) Confidence 0.25 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.67
Co-activation of PKA and PKC in cerebrocortical nerve terminals synergistically facilitates glutamate release.
Positive_regulation (facilitates) of Positive_regulation (activation) of PKA in nerve associated with glutamate
5) Confidence 0.21 Published 2003 Journal J. Neurochem. Section Title Doc Link 14622090 Disease Relevance 0 Pain Relevance 0.49
The effects of Hcy on ERK cascade activation were also dependent on calcium influx, CaMK-II, PKC as well as PKA activation.
Positive_regulation (dependent) of Positive_regulation (activation) of PKA
6) Confidence 0.17 Published 2005 Journal Neuroscience Section Abstract Doc Link 15916860 Disease Relevance 0.20 Pain Relevance 0.30
PKA activation increases the NaV1.8 density on the membrane through direct phosphorylation.


Positive_regulation (increases) of Positive_regulation (activation) of PKA
7) Confidence 0.14 Published 2010 Journal Neuroscience Letters Section Abstract Doc Link PMC2977848 Disease Relevance 0.36 Pain Relevance 0.41
This cascade results in increases of CREB and BDNF expression and increases in the levels of cAMP-dependent protein kinase (PKA) [4,115,137-139].
Positive_regulation (results) of Positive_regulation (increases) of PKA associated with bdmf
8) Confidence 0.09 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 1.11 Pain Relevance 0.42
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Positive_regulation (required) of Positive_regulation (Activated) of PKA associated with pain and qutenza
9) Confidence 0.09 Published 2005 Journal Pain Section Title Doc Link 16150547 Disease Relevance 0.48 Pain Relevance 1.00
There is much evidence that the cAMP/PKA activation leads to the immediate induction of the vasopressin gene expression.
Positive_regulation (induction) of Positive_regulation (activation) of PKA
10) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.33 Pain Relevance 0.11
The activation of the PKA signaling also increases the CRH gene expression in rat fetal hypothalamic cultures (Emanuel et al. 1992), or primary amygdalar cultures (Kasckow et al. 1997).
Positive_regulation (increases) of Positive_regulation (activation) of PKA
11) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.10 Pain Relevance 0
A rapid accumulation of the intracellular cAMP and the subsequent activation of protein kinase A (PKA) is observed, after vasopressin in the circulation binds V2R.
Positive_regulation (accumulation) of Positive_regulation (activation) of PKA
12) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0
CREB antisense oligonucleotide infusions completely blocked the morphine-induced upregulation of type VIII adenylyl cyclase but not of PKA.
Positive_regulation (morphine-induced) of Positive_regulation (upregulation) of PKA associated with morphine
13) Confidence 0.08 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9315909 Disease Relevance 0.22 Pain Relevance 1.16
In the absence of PKA inhibitors, isoproterenol increased the phosphorylation state of CREB within 5 min returning to basal after 60 min (n = 3).
Positive_regulation (increased) of Positive_regulation (absence) of PKA
14) Confidence 0.07 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.12 Pain Relevance 0.06
The experimental evidence indicates that the effect of PGE2 is mediated by an elevation in cAMP levels and activation of PKA.
Positive_regulation (elevation) of Positive_regulation (activation) of PKA in PGE2
15) Confidence 0.07 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771643 Disease Relevance 0.56 Pain Relevance 0.31
The obtained results suggest that increased activation of the PKA-dependent pathway may constitute an important molecular basis for some (suppression of TNF-alpha production), but not all (suppression of IFN-gamma production), negative immunoregulatory effects of fluoxetine.
Positive_regulation (increased) of Positive_regulation (activation) of PKA associated with fluoxetine
16) Confidence 0.07 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15683856 Disease Relevance 0.14 Pain Relevance 0.70
-AR mediated rise in cAMP production, it remained unclear whether phosphorylation of ERK was dependent upon this cAMP-dependent activation of PKA.
Spec (whether) Positive_regulation (dependent) of Spec (whether) Positive_regulation (activation) of PKA
17) Confidence 0.07 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.05 Pain Relevance 0.03
Activation of these receptors in nociceptors leads to activation of phospholipase C (PLC), phospholipase A2 (PLA2), adenylyl cyclase, protein kinase C (PKC) and protein kinase A (PKA) signaling pathways.
Positive_regulation (leads) of Positive_regulation (activation) of PKA in nociceptors associated with kinase c and nociceptor
18) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.25 Pain Relevance 0.65
This demonstrates that secretion does not require an increase in intracellular cAMP nor a PKA specific activation.
Neg (nor) Positive_regulation (require) of Neg (nor) Positive_regulation (activation) of PKA
19) Confidence 0.04 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.44 Pain Relevance 0
Additionally, the observed increases in cAMP may result in activation of PKA, whereas increased [Ca2+]i may result in activation of CaMKII.
Positive_regulation (increased) of Positive_regulation (activation) of PKA
20) Confidence 0.04 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583213 Disease Relevance 0.08 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox