INT7148

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.19
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
spinal 4
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 2 99.56 Very High Very High Very High
Inflammation 8 97.36 Very High Very High Very High
Enkephalin 19 96.44 Very High Very High Very High
Spinal cord 4 92.96 High High
halothane 2 91.68 High High
tolerance 19 86.76 High High
Dorsal horn 2 86.04 High High
c fibre 4 84.24 Quite High
Calcitonin gene-related peptide 7 82.60 Quite High
analgesia 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 11 98.86 Very High Very High Very High
Insulin Resistance 8 98.80 Very High Very High Very High
Neurogenic Inflammation 6 97.80 Very High Very High Very High
Obesity 38 96.00 Very High Very High Very High
Viral Infection 2 95.48 Very High Very High Very High
Disease 3 94.24 High High
Stress 10 88.32 High High
Impaired Glucose Tolerance 20 86.76 High High
Weight Gain 9 85.64 High High
Natriuresis 5 80.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here the inhibitory effects on spinal nociceptive transmission of bestatin, a non-specific aminopeptidase inhibitor, thiorphan, an inhibitor of enkephalinase and kelatorphan, a mixed inhibitor of aminopeptidases, particularly aminopeptidase M, enkephalinase and dipeptidylaminopeptidase.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of enkephalinase in spinal associated with nociception
1) Confidence 0.42 Published 1987 Journal Brain Res. Section Abstract Doc Link 3474047 Disease Relevance 0.26 Pain Relevance 0.58
We report here the inhibitory effects on spinal nociceptive transmission of bestatin, a non-specific aminopeptidase inhibitor, thiorphan, an inhibitor of enkephalinase and kelatorphan, a mixed inhibitor of aminopeptidases, particularly aminopeptidase M, enkephalinase and dipeptidylaminopeptidase.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of enkephalinase in spinal associated with nociception
2) Confidence 0.37 Published 1987 Journal Brain Res. Section Abstract Doc Link 3474047 Disease Relevance 0.26 Pain Relevance 0.66
We investigated the effect of bestatin, a specific inhibitor of aminopeptidase and thiorphan, a specific inhibitor of enkephalinase A, on the analgesic effect induced by the intracerebral injection of heptapeptide [Met5]enkephalin-Arg6-Phe7 (MEAP) in cannulated rats.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of enkephalinase associated with analgesic and enkephalin
3) Confidence 0.25 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6391939 Disease Relevance 0 Pain Relevance 0.76
Thus, we conclude that dual inhibition of angiotensin converting enzyme and neutral endopeptidase may be more effective than monotherapy in reducing insulin resistance and the complications associated with diet induced obesity.



Negative_regulation (effective) of Negative_regulation (inhibition) of neutral endopeptidase associated with obesity and insulin resistance
4) Confidence 0.24 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.94 Pain Relevance 0.08
Thus, down-regulation of enkephalinase activity in specific tissues can modify the extent of neurogenic inflammation, and this modification could be important in the pathogenesis of diseases in airways and other tissues that contain tachykinins.
Negative_regulation (-) of Negative_regulation (regulation) of enkephalinase associated with inflammation, disease and neurogenic inflammation
5) Confidence 0.10 Published 1992 Journal Glas Srp Akad Nauka Med Section Abstract Doc Link 1340478 Disease Relevance 0.36 Pain Relevance 0.33
Thus, down-regulation of enkephalinase activity in specific tissues can modify the extent of neurogenic inflammation, and this modification could be important in the pathogenesis of diseases in airways and other tissues that contain tachykinins.
Negative_regulation (down) of Negative_regulation (regulation) of enkephalinase associated with inflammation, disease and neurogenic inflammation
6) Confidence 0.10 Published 1992 Journal Glas Srp Akad Nauka Med Section Abstract Doc Link 1340478 Disease Relevance 0.36 Pain Relevance 0.33

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