INT71487

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.73
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR7) signal transducer activity (HTR7)
Anatomy Link Frequency
dorsal root ganglia 1
embryonic kidney 1
HTR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 4 100.00 Very High Very High Very High
agonist 16 97.48 Very High Very High Very High
antagonist 8 95.88 Very High Very High Very High
Serotonin 7 95.72 Very High Very High Very High
Somatostatin 2 88.60 High High
Sumatriptan 8 86.08 High High
tolerance 1 81.28 Quite High
Pain 3 79.48 Quite High
Dorsal horn neuron 1 77.72 Quite High
central sensitization 1 76.88 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 5 99.16 Very High Very High Very High
Nociception 2 93.68 High High
Impaired Glucose Tolerance 1 81.28 Quite High
Pain 3 79.48 Quite High
Hyperalgesia 1 74.76 Quite High
Chronobiology Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From our study, we speculate that activation of the 5-hydroxytryptamine-1 receptor inhibits endocrine pancreatic secretion.
Positive_regulation (activation) of 5-hydroxytryptamine
1) Confidence 0.67 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486164 Disease Relevance 0.08 Pain Relevance 0.58
In the present study on transfected human embryonic kidney (HEK)293 cells, we aimed at establishing whether expression of the naturally occurring Thr92Lys variation of the Gs-coupled h5-HT7(a) receptor leads to changes of ligand binding properties, of agonist-evoked cAMP formation and/or of antagonist-mediated blockade of the latter.
Spec (whether) Positive_regulation (variation) of 5-HT7 in embryonic kidney associated with antagonist and agonist
2) Confidence 0.49 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 15896881 Disease Relevance 0 Pain Relevance 0.17
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.
Positive_regulation (activation) of 5-HT7 associated with qutenza and hypersensitivity
3) Confidence 0.45 Published 2009 Journal Pain Section Title Doc Link 19118950 Disease Relevance 0.43 Pain Relevance 0.82
The presence of 5-HT1D alpha, 5-HT1D beta, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT7 receptor subtype messenger RNA was detected in dorsal root ganglia from three of the four subjects. 5-HT1A receptor subtype messenger RNA was detected in one of the four subjects.
Positive_regulation (presence) of 5-HT7 in dorsal root ganglia
4) Confidence 0.21 Published 1997 Journal Neuroscience Section Abstract Doc Link 9316030 Disease Relevance 0.22 Pain Relevance 0.49

General Comments

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