INT71488

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.70
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
nerve 1
dorsal root ganglia 1
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 2 99.80 Very High Very High Very High
sSRI 2 99.58 Very High Very High Very High
Migraine 4 98.96 Very High Very High Very High
Neurotransmitter 3 93.48 High High
Serotonin 7 90.72 High High
Peripheral nervous system 1 84.48 Quite High
antidepressant 3 78.68 Quite High
Hyperalgesia 1 67.88 Quite High
Pain 2 67.20 Quite High
headache 2 55.76 Quite High
Disease Link Frequency Relevance Heat
Headache 6 98.96 Very High Very High Very High
Disease 1 92.84 High High
Increased Venous Pressure Under Development 1 91.60 High High
Hyperalgesia 1 67.88 Quite High
Pain 2 67.20 Quite High
Epilepsy 1 41.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of T3, alone and together with the SSRI fluoxetine, on mRNA levels for the 5-HT1A and 5-HT1B autoreceptors, which mediate serotonergic neurotransmission by feedback actions at the levels of cell firing(somatodendritic 5-HT1A autoreceptors) and neurotransmitter release (nerve terminal 5-HT1B autoreceptors) were also determined.
Spec (determined) Transcription (levels) of 5-HT1A in nerve associated with neurotransmitter, ssri and fluoxetine
1) Confidence 0.69 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16475961 Disease Relevance 0 Pain Relevance 0.55
The human 5-HT1A receptor gene transcription is modulated by a functional C-1019G promoter polymorphism.
Transcription (transcription) of 5-HT1A
2) Confidence 0.69 Published 2007 Journal J Neural Transm Section Abstract Doc Link 17417740 Disease Relevance 0.50 Pain Relevance 0.34
The presence of 5-HT1D alpha, 5-HT1D beta, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT7 receptor subtype messenger RNA was detected in dorsal root ganglia from three of the four subjects. 5-HT1A receptor subtype messenger RNA was detected in one of the four subjects.
Transcription (detected) of 5-HT1A in dorsal root ganglia
3) Confidence 0.67 Published 1997 Journal Neuroscience Section Abstract Doc Link 9316030 Disease Relevance 0.20 Pain Relevance 0.47

General Comments

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