INT7149

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.34
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
brain 1
respiratory tract 1
urine 1
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 99.90 Very High Very High Very High
bradykinin 1 95.04 Very High Very High Very High
Enkephalin 6 93.44 High High
Neuropeptide 2 85.80 High High
substance P 7 81.96 Quite High
addiction 1 73.68 Quite High
qutenza 2 54.28 Quite High
antagonist 1 41.40 Quite Low
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 3 98.88 Very High Very High Very High
Natriuresis 1 94.24 High High
Adhesions 1 73.04 Quite High
Viral Infection 1 14.16 Low Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mercaptoacetyl dipeptides (2-mercaptoacetyl-Leu-Phe and 2-mercaptoacetyl-Phe-Leu) and the N-phosphorylated dipeptides (phosphoryl-Leu-Phe and phosphoramidon) inhibited enkephalinase with IC50 values of 15, 70, 0.3 and 1 nM respectively, but were much less potent against the aminopeptidase and angiotensin converting enzyme, two other metalloenzymes implicated in the degradation of the enkephalins in brain.
Phosphorylation (phosphorylated) of enkephalinase in brain associated with enkephalin
1) Confidence 0.60 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6352283 Disease Relevance 0 Pain Relevance 0.32
A soluble form of NEP was previously identified in human urine with characteristics similar to the renal enzyme.
Phosphorylation (form) of NEP in urine
2) Confidence 0.49 Published 1995 Journal Kidney Int. Section Abstract Doc Link 7752584 Disease Relevance 0.09 Pain Relevance 0.18
[The role of enkephalinase (neutral endopeptidase) in neurogenic inflammation of the respiratory tract].
Phosphorylation (role) of enkephalinase in respiratory tract associated with inflammation and neurogenic inflammation
3) Confidence 0.17 Published 1992 Journal Glas Srp Akad Nauka Med Section Title Doc Link 1340478 Disease Relevance 0.24 Pain Relevance 0.47

General Comments

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