INT71494

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 14
Total Number 18
Disease Relevance 8.50
Pain Relevance 9.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspa1b) mitochondrion (Hspa1b) nucleus (Hspa1b)
intracellular (Hspa1b) protein complex (Hspa1b) response to stress (Hspa1b)
Anatomy Link Frequency
liver 3
plasma 1
Hepatocytes 1
nerve 1
nervous system 1
Hspa1b (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 110 99.96 Very High Very High Very High
Painful diabetic neuropathy 4 99.76 Very High Very High Very High
Morphine 344 99.48 Very High Very High Very High
allodynia 8 98.36 Very High Very High Very High
Neuropathic pain 4 97.40 Very High Very High Very High
cocaine 10 94.00 High High
diabetic neuropathy 64 91.44 High High
Glutamate receptor 2 87.64 High High
Neuropeptide 6 85.96 High High
Hyperalgesia 4 84.08 Quite High
Disease Link Frequency Relevance Heat
Shock 48 100.00 Very High Very High Very High
Diabetic Neuropathy 68 99.76 Very High Very High Very High
Sprains And Strains 164 99.10 Very High Very High Very High
Neuropathic Pain 48 98.36 Very High Very High Very High
Hepatotoxicity 25 98.24 Very High Very High Very High
Nervous System Injury 16 95.92 Very High Very High Very High
Stress 22 94.96 High High
Nervous System Malformation 8 94.32 High High
Injury 6 90.72 High High
Diabetes Mellitus 108 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, they report the characteristics of KU-32, a small molecule based on novobiocin, which inhibits HSP90, thereby inducing neuroprotective HSP70.
Positive_regulation (inducing) of HSP70
1) Confidence 0.67 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2936743 Disease Relevance 0.62 Pain Relevance 0.11
The authors go on to test the capacity of HSP70 induction to protect cells of the nervous system from exogenous stressors.
Positive_regulation (induction) of HSP70 in nervous system
2) Confidence 0.67 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2936743 Disease Relevance 0.62 Pain Relevance 0.12
The authors also speculate that KU-32 may have the potential to ameliorate aspects of painful diabetic neuropathy and indeed induction of HSP70 has previously been shown to ameliorate allodynia in a model of neuropathic pain induced by physical nerve injury (Kalmar et al., 2003).
Positive_regulation (induction) of HSP70 in nerve associated with painful diabetic neuropathy, nervous system injury, allodynia and neuropathic pain
3) Confidence 0.67 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2936743 Disease Relevance 1.32 Pain Relevance 0.67
In strain DBA/2J, the level of heat shock protein 1B (Hspa1b) mRNA was increased after acute morphine by about 2.5-fold over control.
Positive_regulation (increased) of Hspa1b associated with shock, sprains and strains and morphine
4) Confidence 0.66 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.67 Pain Relevance 0.43
The use of HSP70-deficient mice to confirm involvement of this protein in the mechanism of action of KU-32 (Figure 6 in Urban et al., 2010) is elegant and the authors note that extension of mechanistic studies, particularly to identify the downstream consequences of HSP70 induction and the cell types in which it occurs after systemic administration of KU-32, will provide valuable information.
Positive_regulation (induction) of HSP70
5) Confidence 0.45 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2936743 Disease Relevance 0.72 Pain Relevance 0.18
For instance, gene transcription of heat shock proteins Hspa1a and Hspa1b was increased.
Positive_regulation (increased) of Hspa1b associated with shock
6) Confidence 0.44 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.31 Pain Relevance 0.29
Even though APAP hepatotoxicity was blocked by NAC administered 0 or 1 hr after the APAP dose, NAC did not inhibit the induction of hsp25 or hsp70i, indicating that APAP arylation of protein may play a key role in triggering hsp induction.
Positive_regulation (induction) of hsp70i associated with paracetamol and hepatotoxicity
7) Confidence 0.11 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9655897 Disease Relevance 0.49 Pain Relevance 1.16
We found a remarkable difference in the patterns of hepatic HSP25 and HSP70i induction in mice that survived after APAP treatment.
Positive_regulation (induction) of HSP70i associated with paracetamol
8) Confidence 0.11 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.48 Pain Relevance 1.21
-treated mice showed increased hsp25 levels at 6 and 24 hr and increased hsp70i levels at 3, 6 and 24 hr.
Positive_regulation (increased) of hsp70i
9) Confidence 0.10 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.17 Pain Relevance 0.43
Hepatocytes with increased hsp25 or hsp70i levels also had detectable reactive metabolite binding from APAP, as determined using immunostaining.
Positive_regulation (increased) of hsp70i in Hepatocytes associated with paracetamol
10) Confidence 0.10 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.24 Pain Relevance 0.54
Immunostaining for hsps confirmed that no increase in hsp25 or hsp70i levels occurred in response to this binding.
Neg (no) Positive_regulation (increase) of hsp70i
11) Confidence 0.10 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.22 Pain Relevance 0.51
Amphetamine has been shown previously to increase levels of the inducible 70-kDa heat shock protein (hsp70i) in mouse liver.
Positive_regulation (increase) of hsp70i in liver associated with shock
12) Confidence 0.09 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.31 Pain Relevance 0.05
Amphetamine has been shown previously to increase levels of the inducible 70-kDa heat shock protein (hsp70i) in mouse liver.
Positive_regulation (inducible) of hsp70i in liver associated with shock
13) Confidence 0.09 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.31 Pain Relevance 0.05
Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90).
Positive_regulation (increased) of hsp70i in body
14) Confidence 0.09 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.46 Pain Relevance 0.18
These results suggest that elevated levels of hsp25 and hsp70i provide protection against acetaminophen and bromobenzene hepatotoxicity.
Positive_regulation (elevated) of hsp70i associated with paracetamol and hepatotoxicity
15) Confidence 0.09 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.47 Pain Relevance 0.42
It was previously shown that a necrogenic dose of acetaminophen (APAP) induced the 25- and 70-kDa heat shock proteins (hsp25 and hsp70i) in mouse liver, whereas nonnecrogenic doses failed to alter the level of either hsp.
Positive_regulation (induced) of hsp70i in liver associated with paracetamol and shock
16) Confidence 0.08 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9655897 Disease Relevance 0.31 Pain Relevance 0.64
We examined changes in survival ratio, plasma APAP level and alanine aminotransferase (ALT) activity, and hepatic reduced glutathione (GSH), HSP25, HSP60, HSC70 and HSP70i levels following treatment of mice with APAP (500 mg/kg, p.o.).
Spec (examined) Positive_regulation (following) of HSP70i in plasma associated with paracetamol
17) Confidence 0.07 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.32 Pain Relevance 0.97
HSP70i levels increased from 1 h onwards after APAP treatment in a time-dependent manner, and reached a maximum at 9 h.
Positive_regulation (increased) of HSP70i associated with paracetamol
18) Confidence 0.07 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.50 Pain Relevance 1.21

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