INT71496

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 15
Total Number 25
Disease Relevance 14.70
Pain Relevance 6.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
podocytes 4
liver 2
plasma 1
Hepatocytes 1
hearts 1
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 95 99.96 Very High Very High Very High
Bioavailability 20 99.52 Very High Very High Very High
cocaine 4 94.00 High High
COX-2 inhibitor 10 89.36 High High
Central nervous system 4 78.16 Quite High
Inflammation 34 65.44 Quite High
fibrosis 20 53.52 Quite High
anesthesia 14 33.28 Quite Low
Disease Link Frequency Relevance Heat
Shock 70 100.00 Very High Very High Very High
Diabetes Mellitus 520 99.68 Very High Very High Very High
Targeted Disruption 384 99.60 Very High Very High Very High
Apoptosis 270 99.40 Very High Very High Very High
Albuminuria 270 99.00 Very High Very High Very High
Hepatotoxicity 18 98.24 Very High Very High Very High
Heat Stress Disorders 10 96.60 Very High Very High Very High
Death 88 95.04 Very High Very High Very High
Coronary Heart Disease 120 91.60 High High
Injury 19 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a remarkable difference in the patterns of hepatic HSP25 and HSP70i induction in mice that survived after APAP treatment.
Positive_regulation (induction) of HSP25 associated with paracetamol
1) Confidence 0.69 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.48 Pain Relevance 1.21
Even though APAP hepatotoxicity was blocked by NAC administered 0 or 1 hr after the APAP dose, NAC did not inhibit the induction of hsp25 or hsp70i, indicating that APAP arylation of protein may play a key role in triggering hsp induction.
Positive_regulation (induction) of hsp25 associated with paracetamol and hepatotoxicity
2) Confidence 0.68 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9655897 Disease Relevance 0.49 Pain Relevance 1.16
HSP70 was significantly increased in NTG mice by oral administration of GGA (Figure 2D and E), whereas no obvious induction of small HSPs such as HSPB8, HSPB1 or HSPB5 was observed.
Neg (no) Positive_regulation (induction) of HSPB1 associated with targeted disruption
3) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.45 Pain Relevance 0
In contrast to NTG mice, GGA treatment markedly enhanced the induction of HSPB8 and HSPB1 in R120G TG mice (Figure 2D and E) with a slight induction of HSP70 (Figure 2D and E).
Positive_regulation (induction) of HSPB1 associated with targeted disruption
4) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.54 Pain Relevance 0.03
M Cur demonstrated the most robust HSP25 signaling activation and was used for all experiments.
Positive_regulation (activation) of HSP25
5) Confidence 0.61 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.17 Pain Relevance 0
These associations generated the hypothesis that early activation of the p38MAPK-HSP25 pathway might be a functional adaptation that maintained podocyte structure and function and prevented albuminuria in response to the glucose stressor.
Positive_regulation (activation) of HSP25 in podocyte associated with albuminuria
6) Confidence 0.61 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.35 Pain Relevance 0
Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90).
Positive_regulation (increased) of hsp25 in body
7) Confidence 0.60 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.45 Pain Relevance 0.18
These results suggest that elevated levels of hsp25 and hsp70i provide protection against acetaminophen and bromobenzene hepatotoxicity.
Positive_regulation (elevated) of hsp25 associated with paracetamol and hepatotoxicity
8) Confidence 0.60 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.47 Pain Relevance 0.42
It was previously shown that a necrogenic dose of acetaminophen (APAP) induced the 25- and 70-kDa heat shock proteins (hsp25 and hsp70i) in mouse liver, whereas nonnecrogenic doses failed to alter the level of either hsp.
Positive_regulation (induced) of hsp25 in liver associated with paracetamol and shock
9) Confidence 0.49 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9655897 Disease Relevance 0.31 Pain Relevance 0.64
Immunostaining for hsps confirmed that no increase in hsp25 or hsp70i levels occurred in response to this binding.
Neg (no) Positive_regulation (increase) of hsp25
10) Confidence 0.48 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.22 Pain Relevance 0.51
Immunohistochemical localization of hsp25 and hsp70i in the liver after APAP treatment showed increases in the levels of both hsps within the zone of affected cells at early time points (3 and 6 hr), but at 24 hr, elevated hsp25 levels were observed primarily in cells on the periphery of the lesions.
Positive_regulation (elevated) of hsp25 in liver associated with paracetamol
11) Confidence 0.48 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.23 Pain Relevance 0.54
Hepatocytes with increased hsp25 or hsp70i levels also had detectable reactive metabolite binding from APAP, as determined using immunostaining.
Positive_regulation (increased) of hsp25 in Hepatocytes associated with paracetamol
12) Confidence 0.48 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.24 Pain Relevance 0.54
-treated mice showed increased hsp25 levels at 6 and 24 hr and increased hsp70i levels at 3, 6 and 24 hr.
Positive_regulation (increased) of hsp25
13) Confidence 0.48 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.17 Pain Relevance 0.43
In contrast, in our in vitro studies in curcumin-treated podocytes, phosphorylated HSP25 was increased, but not total HSP25 (not shown).
Positive_regulation (increased) of HSP25 in podocytes
14) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.05 Pain Relevance 0
Curcumin activated renal cortical p38MAPK and reduced total HSP25 in Stz-DM mice
Positive_regulation (activated) of HSP25 associated with diabetes mellitus
15) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.84 Pain Relevance 0.05
Since phosphorylated p38MAPK is one of the major regulators of the phosphorylation of downstream HSP25, activation of the p38MAPK-HSP25 pathway may explain both the tendency towards maintenance of the actin cytoskeleton and the attenuation of apoptosis in this in vitro model.
Positive_regulation (activation) of HSP25 associated with apoptosis
16) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.01 Pain Relevance 0
Taken together, our in vitro data demonstrate that in podocytes cultured in normal or high glucose media, curcumin activates the p38MAPK-HSP25 pathway, inhibits COX-2, attenuates apoptosis, and likely contributes towards the trend for cytoskeletal maintenance.
Positive_regulation (activates) of HSP25 in podocytes associated with apoptosis
17) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.78 Pain Relevance 0.04
While GGA increased the expression levels of HSPB8 and HSPB1 as well as HSP70 in a dose-dependent manner, no induction of HSPB5 was observed (Figure 1A and B).
Positive_regulation (increased) of HSPB1
18) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.44 Pain Relevance 0
HSP70 expression was significantly increased in the hearts of NTG mice treated with GGA, but there was no obvious induction in other small HSPs such as HSPB8, HSPB1 and HSPB5.
Neg (no) Positive_regulation (induction) of HSPB1 in hearts associated with targeted disruption
19) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.61 Pain Relevance 0.04
Through the stabilization of actin, phosphorylated HSP25 may attenuate apoptosis.
Positive_regulation (stabilization) of HSP25 associated with apoptosis
20) Confidence 0.41 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.86 Pain Relevance 0

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