INT71498

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 7.38
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
cardiomyocytes 2
temporomandibular joint 2
podocytes 2
Hepatocytes 1
filaments 1
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.76 Very High Very High Very High
Snapping jaw 8 98.20 Very High Very High Very High
fibrosis 10 56.32 Quite High
Kinase C 13 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Bioavailability 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 28 100.00 Very High Very High Very High
Alzheimer's Dementia 68 99.96 Very High Very High Very High
Disease 40 98.92 Very High Very High Very High
Renal Disease 156 98.56 Very High Very High Very High
Temporomandibular Joint Syndrome 8 98.20 Very High Very High Very High
Coronary Heart Disease 60 97.92 Very High Very High Very High
Death 41 97.16 Very High Very High Very High
Apoptosis 129 96.80 Very High Very High Very High
Hepatotoxicity 1 95.92 Very High Very High Very High
Albuminuria 108 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration (up to 4 hours) resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
HSP25 Binding (associated) of in podocytes
1) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.49 Pain Relevance 0
Earlier studies have demonstrated immunoreactivity for heat shock protein 25 (Hsp25) in type B synovial lining cells of the rat temporomandibular joint, and also the presence of characteristic cytoplasmic processes in these cells, but it is unclear whether or not the type B cells in other animals possess such elaborate cytoplasmic projections and as there is as yet no evidence for the synthesis of this protein by these cells.
heat shock protein 25 Binding (immunoreactivity) of in temporomandibular joint associated with snapping jaw and shock
2) Confidence 0.37 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11451409 Disease Relevance 0.41 Pain Relevance 0.24
Earlier studies have demonstrated immunoreactivity for heat shock protein 25 (Hsp25) in type B synovial lining cells of the rat temporomandibular joint, and also the presence of characteristic cytoplasmic processes in these cells, but it is unclear whether or not the type B cells in other animals possess such elaborate cytoplasmic projections and as there is as yet no evidence for the synthesis of this protein by these cells.
Hsp25 Binding (immunoreactivity) of in temporomandibular joint associated with snapping jaw and shock
3) Confidence 0.37 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11451409 Disease Relevance 0.41 Pain Relevance 0.24
Hepatocytes with increased hsp25 or hsp70i levels also had detectable reactive metabolite binding from APAP, as determined using immunostaining.
hsp25 Binding (binding) of in Hepatocytes associated with paracetamol
4) Confidence 0.36 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.24 Pain Relevance 0.55
While we have shown that HSPB1 and HSPB8 can directly interrupt amyloid oligomer formation caused by HSPB5 R120G and restore cellular viability in cardiomyocytes expressing HSPB5 R120G, the in vivo protective effects of the small HSPs on the development of DRM remain unproven.
HSPB1 Binding (interrupt) of in cardiomyocytes associated with alzheimer's dementia and coronary heart disease
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.42 Pain Relevance 0.03
Non-phosphorylated HSP25 oligomers also enhance cell survival, but through mechanisms involving the inhibition of canonical targets in the mitochondrial and death-domain apoptotic pathways and through inhibition of NF?
HSP25 Binding (oligomers) of associated with apoptosis and death
6) Confidence 0.33 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.06 Pain Relevance 0
Our previous in vitro study showed that HSPB8 and HSPB1, which can bind to HSPB5 R120G, inhibited amyloid oligomer formation and reduced cell death in the R120G transfected cardiomyocytes [15].
HSPB1 Binding (bind) of in cardiomyocytes associated with alzheimer's dementia and death
7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.42 Pain Relevance 0
In other studies in vitro, direct binding of HSP25/27 to the upstream regulator of NF?
HSP25 Binding (binding) of
8) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.19 Pain Relevance 0
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
HSP25 Binding (associated) of in podocytes
9) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.24 Pain Relevance 0
Similarly, HSP25 was found to interact with actin filaments and to prevent formation of aggregates of thermally denatured actin (Panasenko et al. 2003).
HSP25 Binding (interact) of in filaments
10) Confidence 0.10 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.50 Pain Relevance 0

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