INT71499

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Context Info
Confidence 0.72
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.38
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
liver 1
brain 1
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 98.76 Very High Very High Very High
Inflammatory response 14 97.98 Very High Very High Very High
Inflammation 108 93.12 High High
midbrain 8 91.68 High High
Hippocampus 4 91.12 High High
interstitial cystitis 2 84.48 Quite High
Spinal cord 1 74.00 Quite High
cerebral cortex 2 72.40 Quite High
substance P 28 37.16 Quite Low
Inflammatory stimuli 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 132 97.80 Very High Very High Very High
Cancer 19 85.48 High High
Metastasis 2 84.72 Quite High
Interstitial Cystitis 2 84.48 Quite High
Shock 16 83.04 Quite High
Apoptosis 6 69.04 Quite High
Hepatotoxicity 1 67.28 Quite High
Death 5 66.56 Quite High
Hematological Disease 4 55.84 Quite High
Clinical Trials And Case Reports 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical localization of hsp25 and hsp70i in the liver after APAP treatment showed increases in the levels of both hsps within the zone of affected cells at early time points (3 and 6 hr), but at 24 hr, elevated hsp25 levels were observed primarily in cells on the periphery of the lesions.
Localization (localization) of hsp25 in liver associated with paracetamol
1) Confidence 0.72 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316869 Disease Relevance 0.22 Pain Relevance 0.49
In the brain, Hspb1, 5, 6, and 8 were found at the mRNA and protein level.
Localization (found) of Hspb1 in brain
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.08 Pain Relevance 0.24
This is the case of elk1, nfkbia, hspb1, dusp1, and akt2.
Localization (case) of hspb1
3) Confidence 0.42 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.25 Pain Relevance 0
Our results indicated that several genes known to be part of the inflammatory response were found downstream of PAR1 activation (b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2).
Localization (ppia) of hspb1 associated with inflammatory response
4) Confidence 0.42 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.82 Pain Relevance 0.33

General Comments

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