INT71504

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.14
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 6 100.00 Very High Very High Very High
fluoxetine 34 99.98 Very High Very High Very High
agonist 16 96.16 Very High Very High Very High
tolerance 1 93.92 High High
addiction 1 92.72 High High
antagonist 16 80.56 Quite High
Serotonin 31 68.64 Quite High
Pyramidal cell 20 63.60 Quite High
antidepressant 5 45.00 Quite Low
5HT 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 75.00 Quite High
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Mental Disorders 2 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low
Rupture 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WAY-100635 given chronically in combination with fluoxetine blocked the SSRI-induced desensitization of the 5-HT1A receptor.
Negative_regulation (blocked) of Negative_regulation (desensitization) of 5-HT1A associated with ssri and fluoxetine
1) Confidence 0.57 Published 2002 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 12095073 Disease Relevance 0.14 Pain Relevance 0.90
A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors.
Negative_regulation (desensitization) of Negative_regulation (reduction) of 5-HT1A
2) Confidence 0.41 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9316875 Disease Relevance 0 Pain Relevance 0.18
Moreover, 5-HT2A/C opposes the 5-HT1A reduction of surface NR2B clusters in a ?
Negative_regulation (opposes) of Negative_regulation (reduction) of 5-HT1A
3) Confidence 0.02 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.24

General Comments

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