INT71510

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 47
Total Number 48
Disease Relevance 30.43
Pain Relevance 12.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 13
plasma 5
chest 3
leukocyte 2
coronary sinus 1
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory marker 35 100.00 Very High Very High Very High
noradrenaline 16 99.96 Very High Very High Very High
Inflammation 235 99.84 Very High Very High Very High
Angina 133 99.78 Very High Very High Very High
withdrawal 35 98.80 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 7 97.88 Very High Very High Very High
ischemia 11 97.76 Very High Very High Very High
analgesia 58 97.56 Very High Very High Very High
cva 18 96.52 Very High Very High Very High
Pain 51 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 274 100.00 Very High Very High Very High
Adhesions 57 100.00 Very High Very High Very High
Syndrome 22 99.86 Very High Very High Very High
Acute Coronary Syndrome 26 99.84 Very High Very High Very High
Cv General 3 Under Development 107 99.78 Very High Very High Very High
Diabetes Mellitus 49 99.70 Very High Very High Very High
Myocardial Infarction 99 99.64 Very High Very High Very High
Coronary Artery Disease 43 99.44 Very High Very High Very High
Disease 21 99.36 Very High Very High Very High
Obstructive Sleep Apnea 163 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest that the increase in the plasma soluble P-selectin levels may be caused by the activation of endothelial cells and platelets after myocardial ischemia and reperfusion during AMI.
Positive_regulation (increase) of P-selectin in endothelial cells associated with coronary artery disease, ischemia and myocardial infarction
1) Confidence 0.68 Published 1998 Journal Am. J. Cardiol. Section Abstract Doc Link 9485126 Disease Relevance 1.04 Pain Relevance 0.24
Our data indicate that the plasma soluble P-selectin levels are increased in patients with AMI, and that the levels are increases after reperfusion therapy more than before reperfusion.
Positive_regulation (increased) of P-selectin in plasma associated with myocardial infarction
2) Confidence 0.68 Published 1998 Journal Am. J. Cardiol. Section Abstract Doc Link 9485126 Disease Relevance 1.08 Pain Relevance 0.28
Endotoxin caused a modest increase in mucosal P-selectin but a very significant increase in the deeper layers.
Positive_regulation (increase) of P-selectin
3) Confidence 0.68 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16020654 Disease Relevance 0.34 Pain Relevance 0.07
Elevated P-selectin level also has been observed in the clinical setting of myocardial ischemia and reperfusion; however, its utility in differentiating cardiac from noncardiac origins of chest pain is unknown.
Positive_regulation (Elevated) of P-selectin in chest associated with angina, coronary artery disease and ischemia
4) Confidence 0.66 Published 2000 Journal Am. Heart J. Section Abstract Doc Link 10650306 Disease Relevance 0.44 Pain Relevance 0.22
CONCLUSIONS: Halothane or sevoflurane anesthesia induces venular leukocyte rolling and adhesion: P-selectin upregulation plays a crucial role in leukocyte rolling and adhesion during sevoflurane anesthesia, whereas low-flow perfusion is likely to evoke ICAM-1-dependent leukocyte adhesion during halothane anesthesia.


Positive_regulation (upregulation) of P-selectin in leukocyte
5) Confidence 0.61 Published 1997 Journal Anesthesiology Section Body Doc Link 9316965 Disease Relevance 0 Pain Relevance 0
Increased P-selectin activity in AMI appeared to be attenuated by direct PTCA, but augmented by thrombolysis, possibly due to direct stimulatory effects of TPA on P-selectin expression.
Positive_regulation (Increased) of P-selectin associated with myocardial infarction and percutaneous transluminal coronary angioplasty
6) Confidence 0.59 Published 1998 Journal Angiology Section Abstract Doc Link 9783645 Disease Relevance 0.95 Pain Relevance 0.50
In contrast, the mean channel fluorescence intensity for P-selectin increased 15 min after coronary stenting in the coronary sinus (19.5 +/- 5.6 to 25.2 +/- 7.5, P < 0.01) and remained elevated for 48 h; the changes were less striking in peripheral blood.
Positive_regulation (elevated) of P-selectin in coronary sinus
7) Confidence 0.49 Published 2006 Journal Platelets Section Abstract Doc Link 16973503 Disease Relevance 0.23 Pain Relevance 0.12
Previous work has shown that P-selectin and mean platelet volume, two markers associated with platelet reactivity, are elevated in acute coronary syndromes.
Positive_regulation (elevated) of P-selectin in platelet associated with acute coronary syndrome
8) Confidence 0.49 Published 2001 Journal Thromb. Haemost. Section Abstract Doc Link 11434707 Disease Relevance 1.09 Pain Relevance 0.46
It has been reported that platelet expression and plasma levels of soluble P-selectin are increased in patients with unstable coronary artery syndromes.
Positive_regulation (increased) of P-selectin in platelet associated with vascular disease
9) Confidence 0.46 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10947910 Disease Relevance 0.48 Pain Relevance 0.23
Increased levels of soluble adhesion molecules E-selectin and P-selectin in patients with cardiac syndrome X.
Positive_regulation (Increased) of P-selectin associated with syndrome and adhesions
10) Confidence 0.44 Published 2005 Journal Angiology Section Title Doc Link 15889194 Disease Relevance 1.09 Pain Relevance 0.25
The mean plasma concentrations of P-selectin were significantly elevated both in patients with coronary artery disease and syndrome X as compared with control subjects (49.15 +/-7.47 and 42.80 +/- 8.93 vs 22.63 +/-6.47 ng/mL, p < 0.001).
Positive_regulation (elevated) of P-selectin in coronary artery associated with coronary artery disease and syndrome
11) Confidence 0.44 Published 2005 Journal Angiology Section Abstract Doc Link 15889194 Disease Relevance 1.45 Pain Relevance 0.33
Patients with a cardiac problem (unstable angina, congestive heart failure, acute myocardial infarction) had significantly elevated levels of soluble P-selectin (156.0 +/- 58.8 ng/mL, P =.002) and platelet-bound P-selectin (11.7% +/- 6.4% positive cells, P =.013) compared with the P-selectin profile among controls (102.6 +/- 29.0 ng/mL, 4.1% +/- 1.2% positivity) and among patients with noncardiac chest pain (114.7 +/- 36.6 ng/mL, 5.7% +/- 2.9% positivity).
Positive_regulation (elevated) of P-selectin in chest
12) Confidence 0.44 Published 2000 Journal Am. Heart J. Section Body Doc Link 10650306 Disease Relevance 0.17 Pain Relevance 0
Patients with a cardiac problem (unstable angina, congestive heart failure, acute myocardial infarction) had significantly elevated levels of soluble P-selectin (156.0 +/- 58.8 ng/mL, P =.002) and platelet-bound P-selectin (11.7% +/- 6.4% positive cells, P =.013) compared with the P-selectin profile among controls (102.6 +/- 29.0 ng/mL, 4.1% +/- 1.2% positivity) and among patients with noncardiac chest pain (114.7 +/- 36.6 ng/mL, 5.7% +/- 2.9% positivity).
Positive_regulation (elevated) of P-selectin in chest
13) Confidence 0.44 Published 2000 Journal Am. Heart J. Section Body Doc Link 10650306 Disease Relevance 0.17 Pain Relevance 0
The results showed that the platelet granule membrane protein 140 (GMP-140) level increased obviously in CHD groups compared with normal control, suggesting that platelet activation existed in CHD.
Positive_regulation (increased) of GMP-140 in platelet associated with coronary artery disease
14) Confidence 0.44 Published 1998 Journal J. Tongji Med. Univ. Section Abstract Doc Link 10806795 Disease Relevance 1.53 Pain Relevance 0.73
Soluble P-selectin levels increased after exercise, but this only reached statistical significance after repeated exercise in claudicants (rising from 320 +/- 28 to 357 +/- 28 ng/ml).
Positive_regulation (increased) of P-selectin
15) Confidence 0.35 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9408015 Disease Relevance 0.38 Pain Relevance 0.23
Increased plasma soluble P-selectin (159.7 +/- 74.5 vs 78.7 +/- 26.4 ng/ml, p < 0.01) and PF-4 (456.5 +/- 87.0 vs 118.7 +/- 62.3 IU/ml, p < 0.01) levels were found in patients with unstable angina compared with those in controls, and were significantly decreased after angioplasty (147.8 +/- 69.6 ng/ml, p < 0.05; 401.6 +/- 108.5 IU/ml, p < 0.05), whereas von Willebrand factor antigen was unchanged.
Positive_regulation (Increased) of P-selectin in plasma associated with angina
16) Confidence 0.32 Published 1999 Journal J Cardiol Section Abstract Doc Link 10354952 Disease Relevance 0.47 Pain Relevance 0.41
Similar changes of P-selectin levels were observed in both groups (9.40 +/- 1.25 ng/mL versus 8.90 +/- 1.34 ng/mL in the control group and 9.56 +/- 1.16 ng/mL versus 7.80 +/- 0.98 ng/mL in the trial group).
Positive_regulation (changes) of P-selectin
17) Confidence 0.32 Published 2007 Journal J Altern Complement Med Section Body Doc Link 17604562 Disease Relevance 0.05 Pain Relevance 0
In conclusion, patients with syndrome X had increased plasma concentrations of soluble adhesion molecules, E-selectin and P-selectin, reflecting an ongoing chronic inflammation involved with endothelial dysfunction and enhanced platelet activation/damage in this setting.
Positive_regulation (increased) of P-selectin in platelet associated with inflammation, syndrome and adhesions
18) Confidence 0.30 Published 2005 Journal Angiology Section Abstract Doc Link 15889194 Disease Relevance 1.38 Pain Relevance 0.29
The results showed that the platelet granule membrane protein 140 (GMP-140) level increased obviously in CHD groups compared with normal control, suggesting that platelet activation existed in CHD.
Positive_regulation (increased) of platelet granule membrane protein 140 in platelet associated with coronary artery disease
19) Confidence 0.29 Published 1998 Journal J. Tongji Med. Univ. Section Abstract Doc Link 10806795 Disease Relevance 1.54 Pain Relevance 0.74
We suggest that the increase in the plasma soluble P-selectin levels may be caused by the activation of endothelial cells and platelets after myocardial ischemia and reperfusion during AMI.
Positive_regulation (increase) of P-selectin in platelets associated with coronary artery disease, ischemia and myocardial infarction
20) Confidence 0.23 Published 1998 Journal Am. J. Cardiol. Section Abstract Doc Link 9485126 Disease Relevance 1.04 Pain Relevance 0.24

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