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Context Info
Confidence 0.35
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.97
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
liver 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 6 99.68 Very High Very High Very High
cytokine 1 52.00 Quite High
Endocannabinoid 3 5.00 Very Low Very Low Very Low
Cannabinoid 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 6 99.68 Very High Very High Very High
Epilepsy 2 99.56 Very High Very High Very High
Cirrhosis 61 98.36 Very High Very High Very High
Increased Venous Pressure Under Development 15 91.32 High High
Pressure And Volume Under Development 29 85.60 High High
Hepatopulmonary Syndrome 14 58.32 Quite High
Varicose Veins 2 57.12 Quite High
Peritonitis 5 56.04 Quite High
Hepatorenal Syndrome 7 54.04 Quite High
Liver Disease 7 43.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mean ET-1 values were elevated in all migraine patients above the range of normal subjects, and were 10.6 (range 6.0-16.0) pg/ml in migraine patients and 3.8 (range 0.7-5.8) pg/ml in controls.
Positive_regulation (elevated) of Regulation (values) of ET-1 associated with migraine
1) Confidence 0.35 Published 1992 Journal Cephalalgia Section Abstract Doc Link 1341430 Disease Relevance 0.66 Pain Relevance 0.54
Its distribution differs in the splanchnic circulation; the intrahepatic microcirculation is altered significantly in liver cirrhosis, secondary to both architectural and vasoactive humoral changes, resulting in an increase in vasoactive molecules including angiotensin II, endothelin 1, and cysteinylleukotrienes associated with a decrease in intrahepatic NO production.
Positive_regulation (increase) of Regulation (molecules) of endothelin 1 in liver associated with cirrhosis
2) Confidence 0.24 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003209 Disease Relevance 1.31 Pain Relevance 0.03

General Comments

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