INT71541

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.02
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pam) lyase activity (Pam)
Anatomy Link Frequency
skin 2
soma 2
Neurons 1
brain 1
Pam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 1 97.44 Very High Very High Very High
Neuropeptide 20 94.40 High High
Morphine 2 89.84 High High
Inflammation 12 88.56 High High
Antinociceptive 1 87.76 High High
Analgesic 3 87.56 High High
Spinal cord 3 87.16 High High
Pain 9 87.04 High High
medulla 2 86.72 High High
Arthritis 1 86.40 High High
Disease Link Frequency Relevance Heat
Meningoencephalitis 6 100.00 Very High Very High Very High
Coma 1 99.68 Very High Very High Very High
Convulsion 1 98.04 Very High Very High Very High
Headache 1 97.44 Very High Very High Very High
Fever 1 97.04 Very High Very High Very High
Hypersensitivity 5 95.28 Very High Very High Very High
Necrosis 1 94.88 High High
Arthritis 1 86.40 High High
Pain 8 81.92 Quite High
INFLAMMATION 11 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAM was only detected at post-mortem.
Gene_expression (detected) of PAM associated with meningoencephalitis
1) Confidence 0.77 Published 1997 Journal Southeast Asian J. Trop. Med. Public Health Section Abstract Doc Link 9322314 Disease Relevance 1.01 Pain Relevance 0.30
Furthermore, the two readouts were highly correlated, and power analysis indicated that PAM was highly reproducible.
Gene_expression (reproducible) of PAM
2) Confidence 0.68 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17383008 Disease Relevance 0.68 Pain Relevance 0.62
MATERIALS AND METHODS: The effects of CDB were evaluated using the following assays: 1) acute inflammation induced by the injection of carrageenan, bradykinin and serotonin into the subplantar region of the hind paw of rats; 2) chronic inflammation produced by the injection of Mycobacterium butyricum into the base of the tail of rats; 3) acute pain induced by the i.p. injection of phenyl-p-quinone into mice resulting in the production of writhes; 4) cyclooxygenase (COX) activity, including COX-1 and COX-2, evaluated using whole blood; and 5) activity of peptidylglycine alpha-monooxygenase (PAM) isolated from Xenopus laevis skin.
Gene_expression (production) of PAM in skin
3) Confidence 0.58 Published 1998 Journal Inflamm. Res. Section Body Doc Link 9719496 Disease Relevance 0.16 Pain Relevance 0
MATERIALS AND METHODS: The effects of CDB were evaluated using the following assays: 1) acute inflammation induced by the injection of carrageenan, bradykinin and serotonin into the subplantar region of the hind paw of rats; 2) chronic inflammation produced by the injection of Mycobacterium butyricum into the base of the tail of rats; 3) acute pain induced by the i.p. injection of phenyl-p-quinone into mice resulting in the production of writhes; 4) cyclooxygenase (COX) activity, including COX-1 and COX-2, evaluated using whole blood; and 5) activity of peptidylglycine alpha-monooxygenase (PAM) isolated from Xenopus laevis skin.
Gene_expression (production) of peptidylglycine alpha-monooxygenase in skin
4) Confidence 0.58 Published 1998 Journal Inflamm. Res. Section Body Doc Link 9719496 Disease Relevance 0.16 Pain Relevance 0
-amidating monooxygenase (PAM) may also be exploited for peptide-based brain-targeting prodrug design [14,15].
Gene_expression (exploited) of PAM in brain
5) Confidence 0.46 Published 2008 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2709471 Disease Relevance 0 Pain Relevance 0.19
To increase the signal obtained, PAM-GFP was expressed in trigeminal neurons; PAM-GFP was visible in tubulovesicular structures in the cell soma and in vesicular structures throughout axonal processes (Figure 8, left).
Gene_expression (expressed) of PAM-GFP in soma
6) Confidence 0.13 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2838897 Disease Relevance 0 Pain Relevance 0
Neurons expressing PAM-GFP were incubated with PHM antibody (JH1761, 1:100) [19] for 15 minutes in basal medium or during stimulation with 1 mM PMA or 50 mM KCl.
Gene_expression (expressing) of PAM-GFP in Neurons
7) Confidence 0.12 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2838897 Disease Relevance 0 Pain Relevance 0
To increase the signal obtained, PAM-GFP was expressed in trigeminal neurons; PAM-GFP was visible in tubulovesicular structures in the cell soma and in vesicular structures throughout axonal processes (Figure 8, left).
Gene_expression (visible) of PAM-GFP in soma
8) Confidence 0.10 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2838897 Disease Relevance 0 Pain Relevance 0

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