INT71544

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Context Info
Confidence 0.16
First Reported 1997
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tgfa) extracellular region (Tgfa) plasma membrane (Tgfa)
nucleus (Tgfa)
Tgfa (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 100.00 Very High Very High Very High
alcohol 2 16.60 Low Low
Central nervous system 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 2 100.00 Very High Very High Very High
Targeted Disruption 19 99.98 Very High Very High Very High
Malignant Neoplastic Disease 7 99.64 Very High Very High Very High
Hepatocellular Cancer 28 98.40 Very High Very High Very High
Liver Cancer 10 83.72 Quite High
Cancer 70 56.64 Quite High
Hyperplasia 16 39.68 Quite Low
Infection 3 28.00 Quite Low
Hepatitis B Virus Infection 1 27.60 Quite Low
Hepatitis 3 24.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The latency of HCC in these transgenic mice is long, but is greatly accelerated by the transgenic overexpression of transforming growth factor-alpha (Murakami et al. 1993; Sargent et al. 1996, 1999; Santoni-Rugiu et al. 1999).
Positive_regulation (overexpression) of Gene_expression (overexpression) of transforming growth factor-alpha associated with targeted disruption and hepatocellular cancer
1) Confidence 0.16 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.15 Pain Relevance 0
BACKGROUND & AIMS: Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of transforming growth factor alpha associated with targeted disruption, malignant neoplastic disease and chronic pancreatitis
2) Confidence 0.15 Published 1997 Journal Gastroenterology Section Abstract Doc Link 9322532 Disease Relevance 0.30 Pain Relevance 0.19

General Comments

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