INT71561

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.67
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adm) aging (Adm) extracellular region (Adm)
response to stress (Adm) cytoplasm (Adm)
Anatomy Link Frequency
plasma 2
cerebral cortex 2
Adm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 2 98.60 Very High Very High Very High
headache 1 92.88 High High
antagonist 2 92.20 High High
COX-2 inhibitor 1 88.08 High High
ischemia 4 86.00 High High
Pyramidal cell 1 79.20 Quite High
Inflammation 3 31.76 Quite Low
cytokine 2 30.72 Quite Low
anesthesia 3 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 80 100.00 Very High Very High Very High
Sepsis 5 99.84 Very High Very High Very High
Hypoxia 4 99.20 Very High Very High Very High
Sleep Disorders 1 94.56 High High
Dizziness 1 94.16 High High
Headache 1 92.88 High High
Vomiting 1 92.36 High High
Cv Unclassified Under Development 2 86.00 High High
Hypertension 5 83.04 Quite High
Stress 18 82.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because ADM is overexpressed in sepsis, we repeated the above protocol in cells isolated from LPS-treated rats.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ADM associated with sepsis
1) Confidence 0.61 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14766677 Disease Relevance 0.27 Pain Relevance 0.13
Adrenomedullin expression is up-regulated by acute hypobaric hypoxia in the cerebral cortex of the adult rat.
Positive_regulation (up-regulated) of Gene_expression (expression) of Adrenomedullin in cerebral cortex associated with hypoxia and cerebral cortex
2) Confidence 0.41 Published 2008 Journal Brain Pathol. Section Title Doc Link 18371176 Disease Relevance 0.66 Pain Relevance 0.22
ADM infusion elevated (P<.05) plasma ADM levels in ADM-infused SHR (679+/-47 pg/mL in ADM-50, 858+/-79 in ADM-100) compared with control (79.5+/-27.8).
Positive_regulation (elevated) of Gene_expression (levels) of ADM in plasma
3) Confidence 0.41 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.60 Pain Relevance 0
This hypothesis is further supported by the found increase in systemic GCL activity in the probiotic pre-treated group, which was markedly enhanced already before the induction of AP.
Positive_regulation (enhanced) of Gene_expression (induction) of AP associated with pancreatitis
4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 1.14 Pain Relevance 0.07

General Comments

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