INT71565

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.16
Pain Relevance 9.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcc) plasma membrane (Prkcc) nucleus (Prkcc)
kinase activity (Prkcc) response to stress (Prkcc) cytoplasm (Prkcc)
Anatomy Link Frequency
pons 1
medulla 1
interneurons 1
hippocampus 1
Prkcc (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 25 100.00 Very High Very High Very High
Morphine 40 99.82 Very High Very High Very High
Neuropathic pain 4 99.82 Very High Very High Very High
antagonist 4 99.72 Very High Very High Very High
Analgesic 4 99.58 Very High Very High Very High
nMDA receptor 2 99.34 Very High Very High Very High
Acute pain 2 99.24 Very High Very High Very High
Peripheral nerve injury 1 99.16 Very High Very High Very High
Pain 4 98.84 Very High Very High Very High
Inflammation 2 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 99.82 Very High Very High Very High
Pain 7 99.24 Very High Very High Very High
Targeted Disruption 11 98.86 Very High Very High Very High
Nervous System Injury 2 98.72 Very High Very High Very High
Hypertrophy 2 98.12 Very High Very High Very High
Hyperalgesia 8 97.80 Very High Very High Very High
Injury 4 96.92 Very High Very High Very High
Frailty 6 89.44 High High
Nociception 1 89.36 High High
Syndrome 1 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When mice were treated with a morphine analgesic dose (7 mg/kg), the downregulation of PLCbeta3 or PKCgamma at the same aODN doses used for the prevention of the hyperalgesic effect induced, respectively, a 46% and 67% potentiation in analgesic response.
Negative_regulation (downregulation) of PKCgamma associated with hyperalgesia, analgesic and morphine
1) Confidence 0.54 Published 2006 Journal Pain Section Abstract Doc Link 16650582 Disease Relevance 0.71 Pain Relevance 1.70
Furthermore, we investigated the rewarding properties of morphine in mice lacking PKCgamma gene.
Negative_regulation (lacking) of PKCgamma gene associated with morphine
2) Confidence 0.43 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.09 Pain Relevance 0.99
The inhibition of morphine-induced increase in PKCgamma phosphorylation reduced Vps34 level.
Negative_regulation (reduced) of PKCgamma associated with morphine
3) Confidence 0.42 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.
Negative_regulation (lacking) of PKCgamma associated with inflammation, acute pain and neuropathic pain
4) Confidence 0.42 Published 1997 Journal Science Section Title Doc Link 9323205 Disease Relevance 0.84 Pain Relevance 1.06
Inhibition of PKCgamma membrane translocation mediated morphine preconditioning-induced neuroprotection against oxygen-glucose deprivation in the hippocampus slices of mice.
Negative_regulation (Inhibition) of PKCgamma in hippocampus associated with hippocampus and morphine
5) Confidence 0.41 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18706478 Disease Relevance 0.07 Pain Relevance 0.44
These findings suggest that the loss of the PKC gamma gene may protect the functional ORL-1 and mu-opioid receptors from degradation by phosphorylation in the mouse pons/medulla.
Negative_regulation (loss) of PKC gamma gene in medulla associated with medulla and mu opioid receptor
6) Confidence 0.38 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.19 Pain Relevance 0.78
Under these conditions, mice lacking the PKCgamma gene failed to show any changes in astroglial hypertrophy or proliferation after repeated treatment with morphine.
Negative_regulation (lacking) of PKCgamma associated with hypertrophy and morphine
7) Confidence 0.38 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14725643 Disease Relevance 0.26 Pain Relevance 1.22
In contrast, L1 KO mice had less CGRP(+) fiber sprouting, but even greater numbers of PKCgamma(+) interneurons at the 6 week time point.
Negative_regulation (numbers) of PKCgamma in interneurons associated with targeted disruption
8) Confidence 0.36 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19059398 Disease Relevance 1.81 Pain Relevance 0.57
These findings suggest that the loss of the PKC gamma gene may protect the functional ORL-1 and mu-opioid receptors from degradation by phosphorylation in the mouse pons/medulla.
Negative_regulation (loss) of PKC gamma gene in pons associated with medulla and mu opioid receptor
9) Confidence 0.13 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.19 Pain Relevance 0.78
There, diacylglycerol (DAG) activates this PKCgamma to phosphorylate the MOR and thus, its signal strength was reduced.
Negative_regulation (reduced) of PKCgamma associated with opioid receptor
10) Confidence 0.08 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18652891 Disease Relevance 0 Pain Relevance 0.72
The N-methyl-D-aspartate receptor (NMDAR) antagonist, MK801, also prevented PKCgamma recruitment to MORs and serine phosphorylation of the receptors following icv morphine.
Negative_regulation (prevented) of PKCgamma associated with antagonist, nmda receptor and morphine
11) Confidence 0.08 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18652891 Disease Relevance 0 Pain Relevance 0.63

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