INT71569

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Context Info
Confidence 1.00
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.80
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map2) intracellular (Map2) protein complex (Map2)
cytoplasm (Map2)
Anatomy Link Frequency
forebrain 2
frontoparietal 1
Map2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 8 99.96 Very High Very High Very High
isoflurane 12 99.92 Very High Very High Very High
halothane 4 99.40 Very High Very High Very High
ischemia 79 99.28 Very High Very High Very High
anesthesia 5 94.72 High High
medulla 44 91.80 High High
Glutamate receptor 1 41.40 Quite Low
cytokine 1 10.80 Low Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 61 99.28 Very High Very High Very High
Shock 6 97.32 Very High Very High Very High
Cv General 4 Under Development 8 94.40 High High
Injury 5 92.16 High High
Death 15 88.76 High High
Apoptosis 1 76.52 Quite High
Transient Ischemic Attack 10 50.00 Quite Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the degree of anesthetic effect on the collapse of cytoskeletal proteins, we compared the effect of three inhalation anesthetics; isoflurane, halothane, and nitrous oxide (N2O), on MAP2 degradation during 20 min of forebrain ischemia in the rat.
Protein_catabolism (degradation) of MAP2 in forebrain associated with ischemia, shock, halothane and isoflurane
1) Confidence 1.00 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9323446 Disease Relevance 0.79 Pain Relevance 0.57
In the frontoparietal cortex and hippocampus, MAP2 was significantly protected from degradation when isoflurane was used combined with nitrogen (N2).
Protein_catabolism (degradation) of MAP2 in frontoparietal associated with isoflurane and hippocampus
2) Confidence 0.66 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9323446 Disease Relevance 0.66 Pain Relevance 0.67
Nitrous oxide attenuates the protective effect of isoflurane on microtubule-associated protein2 degradation during forebrain ischemia in the rat.
Protein_catabolism (degradation) of microtubule-associated protein2 in forebrain associated with ischemia and isoflurane
3) Confidence 0.58 Published 1997 Journal Brain Res. Bull. Section Title Doc Link 9323446 Disease Relevance 0.75 Pain Relevance 0.52
The ischemia-induced rapid elevation of intracellular Ca2+ concentration and subsequent activation of Ca2+-dependent phosphatases (e.g., calcineurin) and proteases (e.g., calpains) can lead to dephosphorylation and proteolytic degradation of MAP2 [18,19].
Protein_catabolism (degradation) of MAP2 associated with ischemia
4) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.60 Pain Relevance 0.16

General Comments

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