INT71587

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Context Info
Confidence 0.01
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpv17l)
Anatomy Link Frequency
oocytes 1
Mpv17l (Rattus norvegicus)
Mpv17l - D114N (1)
Pain Link Frequency Relevance Heat
agonist 18 100.00 Very High Very High Very High
narcan 13 97.60 Very High Very High Very High
methadone 1 97.16 Very High Very High Very High
Immobilon 2 96.60 Very High Very High Very High
antagonist 4 95.60 Very High Very High Very High
tetrodotoxin 3 94.92 High High
lidocaine 2 94.76 High High
Buprenorphine 2 94.20 High High
opioid receptor 10 92.56 High High
Enkephalin 4 88.96 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chloroquine or proteasome inhibitor I reduced the down-regulation of the mutant.
Negative_regulation (down-regulation) of mutant
1) Confidence 0.01 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641435 Disease Relevance 0 Pain Relevance 0.73
The reduced affinities of the full agonists for the D114N mutant did not involve an uncoupling of the receptor from G proteins because methadone and etorphine stimulated the D114N mu receptors to inhibit adenylyl cyclase.
Negative_regulation (reduced) of D114N mutant (D114N) associated with agonist, methadone and immobilon
2) Confidence 0.01 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9422382 Disease Relevance 0 Pain Relevance 1.29
However, Rg(3) treatment inhibited the peak and plateau I(Na) in the IFMQ3 mutant, indicating that Rg(3) inhibits both the resting and open states of Na(+) channel.
Negative_regulation (inhibited) of IFMQ3 mutant
3) Confidence 0.00 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16014805 Disease Relevance 0 Pain Relevance 0.41
In addition, injection of CaM kinase II in Xenopus oocytes led only to desensitization of expressed rMOR1, but not of an S261A/S266A receptor mutant.
Negative_regulation (desensitization) of mutant in oocytes
4) Confidence 0.00 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.37

General Comments

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