INT71588

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.32
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a)
Anatomy Link Frequency
neurons 2
cerebral artery 1
synapses 1
hippocampus 1
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 10 99.00 Very High Very High Very High
Hippocampus 3 98.68 Very High Very High Very High
Glutamate 8 97.92 Very High Very High Very High
long-term potentiation 27 97.76 Very High Very High Very High
spinal dorsal horn 7 96.04 Very High Very High Very High
central sensitization 26 95.44 Very High Very High Very High
Kinase C 37 94.72 High High
agonist 3 92.76 High High
nMDA receptor 4 88.28 High High
Nicotine 2 86.68 High High
Disease Link Frequency Relevance Heat
Nociception 38 92.88 High High
Anaerobic Bacterial Infections 1 25.00 Low Low
Pain 4 20.52 Low Low
Injury 2 19.56 Low Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation and activity of CaM kinase IV as well as CaM kinase II were increased by treatment of neurons either with glutamate or high K(+).
Phosphorylation (Phosphorylation) of CaM kinase II in neurons associated with glutamate
1) Confidence 0.65 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.30
We report the properties of phosphorylation and activation of CaM kinase IV in comparison to CaM kinase II in cultured rat hippocampal neurons.
Phosphorylation (phosphorylation) of CaM kinase II in neurons
2) Confidence 0.64 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10686587 Disease Relevance 0 Pain Relevance 0.24
Postsynaptic autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) at Thr286/287 is crucial for the induction of long-term potentiation at many glutamatergic synapses, and has also been implicated in the persistence of synaptic potentiation.
Phosphorylation (autophosphorylation) of calmodulin-dependent protein kinase II in synapses associated with long-term potentiation
3) Confidence 0.46 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15932602 Disease Relevance 0.14 Pain Relevance 0.08
The increase of desensitization could not be observed with a mu-opioid receptor mutant (S261A/S266A) that lacks two putative CaM kinase II phosphorylation sites in the third intracellular loop.
Neg (lacks) Phosphorylation (phosphorylation) of kinase II associated with opioid receptor
4) Confidence 0.39 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.38
It is concluded that the phosphorylation pathway involving Ca2+/calmodulin-dependent protein kinase II, but not other protein kinases so far tested, appears to be involved in the function of vasodilator nerves innervating the cerebral artery.
Phosphorylation (phosphorylation) of Ca2+/calmodulin-dependent protein kinase II in cerebral artery
5) Confidence 0.34 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9527507 Disease Relevance 0 Pain Relevance 0.19
Additionally, the coordinated phosphorylation of CREB was initiated by the rapid phosphorylation of MAP kinase, as well as other activated protein kinases, such as calcium/calmodulin protein-dependent kinase II (CaM kinase II), protein kinase A and C [6,9,17,22-24].
Phosphorylation (phosphorylation) of kinase II
6) Confidence 0.24 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.09 Pain Relevance 0.55
Additionally, the coordinated phosphorylation of CREB was initiated by the rapid phosphorylation of MAP kinase, as well as other activated protein kinases, such as calcium/calmodulin protein-dependent kinase II (CaM kinase II), protein kinase A and C [6,9,17,22-24].
Phosphorylation (phosphorylation) of kinase II
7) Confidence 0.24 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.09 Pain Relevance 0.55
In the hippocampus, a rise of Ca(2+) activates calcium/calmodulin-dependent protein kinase II (CaMK II) through autophosphorylation.
Phosphorylation (autophosphorylation) of kinase II in hippocampus associated with hippocampus
8) Confidence 0.10 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 14985835 Disease Relevance 0 Pain Relevance 0.75

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