INT71592

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.03
Pain Relevance 10.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
RVM 2
spinal cord segments 2
brain 2
oocytes 2
Spinal 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 30 100.00 Very High Very High Very High
Opioid 19 100.00 Very High Very High Very High
Rostroventromedial medulla 9 100.00 Very High Very High Very High
mu opioid receptor 8 100.00 Very High Very High Very High
Spinal cord 5 100.00 Very High Very High Very High
Dorsal horn 2 100.00 Very High Very High Very High
Arthritis 21 99.98 Very High Very High Very High
cocaine 17 99.98 Very High Very High Very High
Nucleus accumbens 2 99.68 Very High Very High Very High
Central grey 2 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 8 99.98 Very High Very High Very High
Diabetes Mellitus 10 99.80 Very High Very High Very High
Urological Neuroanatomy 2 99.68 Very High Very High Very High
Hyperglycemia 2 99.48 Very High Very High Very High
Cv Unclassified Under Development 3 99.44 Very High Very High Very High
Experimental Arthritis 13 98.52 Very High Very High Very High
Pain 7 98.52 Very High Very High Very High
Neuropathic Pain 6 98.12 Very High Very High Very High
Spinal Cord Ischemia 3 93.60 High High
Hyperalgesia 9 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the acute treatment, expression levels for the encoded mu-opioid receptor Oprm1, as detected by reverse transcription-polymerase chain reaction, were significantly decreased in the periaqueductal gray.
Negative_regulation (decreased) of Gene_expression (expression) of Oprm1 associated with opioid receptor and central grey
1) Confidence 0.58 Published 2006 Journal Neuroscience Section Abstract Doc Link 16753266 Disease Relevance 0.27 Pain Relevance 0.64
Immunohistochemical staining demonstrated that the level of mu-opioid receptor expression in the dorsal horn of spinal cord segments receiving input from the allodynic skin was markedly reduced 2 days after ischemia, when the rats were allodynic.
Negative_regulation (reduced) of Gene_expression (expression) of mu-opioid receptor in spinal cord segments associated with ischemia, dorsal horn, opioid receptor and spinal cord
2) Confidence 0.56 Published 1999 Journal Neuroreport Section Abstract Doc Link 10094139 Disease Relevance 0.62 Pain Relevance 1.54
Autoradiographic evidence that prolonged withdrawal from intermittent cocaine reduces mu-opioid receptor expression in limbic regions of the rat brain.
Negative_regulation (reduces) of Gene_expression (expression) of mu-opioid receptor in brain associated with opioid receptor, withdrawal and cocaine
3) Confidence 0.56 Published 2000 Journal Synapse Section Title Doc Link 10891866 Disease Relevance 0 Pain Relevance 0.71
Spinal mu-opioid receptor expression decreased significantly only on Day 21 in the AA + dexamethasone group compared with the AA alone group.
Negative_regulation (decreased) of Gene_expression (expression) of mu-opioid receptor in Spinal associated with opioid receptor, dexamethasone and arthritis
4) Confidence 0.51 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671722 Disease Relevance 1.70 Pain Relevance 1.77
Immunohistochemical and real-time PCR analysis of the L3-L5 dorsal root ganglia ipsilateral to the chronic arthritis lesion revealed a reduction in mu-opioid receptor protein and gene expression compared with that in normal control animals.
Negative_regulation (reduction) of Gene_expression (expression) of mu-opioid receptor protein in dorsal root ganglia
5) Confidence 0.43 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 16200625 Disease Relevance 0 Pain Relevance 0
Thus, loss of RVM mu receptor-expressing cells both prevents and reverses experimental neuropathic pain.
Negative_regulation (loss) of Gene_expression (expressing) of RVM mu receptor-expressing in RVM associated with rostroventromedial medulla and neuropathic pain
6) Confidence 0.42 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11438603 Disease Relevance 0.51 Pain Relevance 1.61
Furthermore, the analgesic effect of endomorphin 1 is lost during chronic inflammation due to down-regulation of mu-opioid receptor expression in afferent nerve cell bodies.
Negative_regulation (down-regulation) of Gene_expression (expression) of mu-opioid receptor in nerve cell
7) Confidence 0.42 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 16200625 Disease Relevance 0 Pain Relevance 0
Chronic arthritis down-regulates peripheral mu-opioid receptor expression with concomitant loss of endomorphin 1 antinociception.
Negative_regulation (down-regulates) of Gene_expression (expression) of mu-opioid receptor associated with antinociception, nociceptor, opioid receptor and arthritis
8) Confidence 0.42 Published 2005 Journal Arthritis Rheum. Section Title Doc Link 16200625 Disease Relevance 0.10 Pain Relevance 0.73
This shows that correction of hyperglycemia in STZ-diabetic rats may reverse the higher gene expression of opioid mu-receptor.
Spec (may) Negative_regulation (reverse) of Gene_expression (expression) of mu-receptor associated with hyperglycemia, diabetes mellitus and opioid
9) Confidence 0.37 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11544560 Disease Relevance 0.77 Pain Relevance 0.74
In males, exposure to endothelin-1 decreased mu opioid receptor expression without changing endothelin-A receptor or endothelin-B receptor expression in the hindpaw skin.
Negative_regulation (decreased) of Gene_expression (expression) of mu opioid receptor in skin associated with mu opioid receptor
10) Confidence 0.35 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19788914 Disease Relevance 0.06 Pain Relevance 1.21
It was found that rats treated with vehicle, but not methadone, responded for the cocaine conditioned stimulus and displayed elevated mu-opioid receptor mRNA expression in the nucleus accumbens core and basolateral amygdala, reduced hypocretin/orexin mRNA in the lateral hypothalamus, and reduced D2 receptor mRNA in the caudate-putamen.
Negative_regulation (displayed) of Gene_expression (expression) of mu-opioid receptor mRNA in nucleus accumbens associated with nucleus accumbens, opioid receptor, methadone, amygdala and cocaine
11) Confidence 0.35 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18990547 Disease Relevance 0 Pain Relevance 1.07
In addition, injection of CaM kinase II in Xenopus oocytes led only to desensitization of expressed rMOR1, but not of an S261A/S266A receptor mutant.
Negative_regulation (desensitization) of Neg (not) Gene_expression (expressed) of rMOR1 in oocytes
12) Confidence 0.07 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.36

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