INT71593

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Context Info
Confidence 0.04
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.68
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpv17l)
Anatomy Link Frequency
stem 1
embryonic kidney 1
oocytes 1
interneurons 1
Mpv17l (Rattus norvegicus)
Mpv17l - D114N (1) Mpv17l - N1417H (1)
Pain Link Frequency Relevance Heat
narcan 37 99.40 Very High Very High Very High
agonist 35 99.00 Very High Very High Very High
GABAergic 2 98.76 Very High Very High Very High
antagonist 9 98.20 Very High Very High Very High
Opioid 1 96.80 Very High Very High Very High
opioid receptor 14 94.04 High High
Enkephalin 6 87.52 High High
Morphine 1 86.32 High High
sodium channel 2 85.32 High High
Spinal cord 66 83.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 97.72 Very High Very High Very High
Convulsion 2 96.36 Very High Very High Very High
Fever 1 93.04 High High
Spinal Cord Injury 33 83.12 Quite High
Febrile Convulsions 5 80.08 Quite High
Generalized Epilepsy 1 79.20 Quite High
Fibrosis 1 79.16 Quite High
Syndrome 2 77.96 Quite High
Pancreatitis 5 75.92 Quite High
Apoptosis 28 59.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whole-cell patch-clamp recordings from HEK cells expressing N1417H mutant channels and from hippocampal GABAergic interneurons of N1417H mutant rats revealed a significant shift of the inactivation curve in the hyperpolarizing direction.
Gene_expression (expressing) of mutant (N1417H) in interneurons associated with gabaergic
1) Confidence 0.04 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20410126 Disease Relevance 0.87 Pain Relevance 0.28
After naloxone removal, binding and protein expression of the mutant declined with time with no effect on its mRNA level.
Gene_expression (expression) of mutant associated with narcan
2) Confidence 0.01 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641435 Disease Relevance 0 Pain Relevance 0.71
Naloxone pretreatment up-regulated [(3)H]diprenorphine binding and protein expression of the D3.49(164)Q mutant in a time- and dose-dependent manner without affecting its mRNA level.
Gene_expression (expression) of mutant associated with narcan
3) Confidence 0.01 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641435 Disease Relevance 0 Pain Relevance 0.60
Expression of the mutant was enhanced by inverse agonists, a neutral antagonist, and agonists, with inverse agonists being most effective.
Gene_expression (Expression) of mutant associated with antagonist and agonist
4) Confidence 0.01 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641435 Disease Relevance 0 Pain Relevance 0.80
The wild-type mu receptor and the D114N mutant were then stably expressed in human embryonic kidney 293 cells, and the binding affinities of a series of opioids were investigated.
Gene_expression (expressed) of D114N mutant (D114N) in embryonic kidney associated with opioid
5) Confidence 0.01 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9422382 Disease Relevance 0 Pain Relevance 0.74
An example of reverse genetics in Tetrahymena is seen in the generation of a behavioral mutant that cannot swim backwards because of a specific dynein knockout [22].
Gene_expression (generation) of mutant associated with targeted disruption
6) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.23 Pain Relevance 0
Therefore we expressed mutant forms of Rho GTPases, Rac, Rho, and Cdc42, in the neural stem/progenitor cells and examined their survival and migration after transplantation.


Spec (examined) Gene_expression (expressed) of mutant in stem
7) Confidence 0.01 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2789715 Disease Relevance 0.22 Pain Relevance 0.08
These effects were observed in mutant receptor-transfected cells as well as cells transfected with the control vector.
Gene_expression (transfected) of mutant receptor
8) Confidence 0.01 Published 2004 Journal Pancreas Section Abstract Doc Link 15211114 Disease Relevance 0.37 Pain Relevance 0.43
In addition, injection of CaM kinase II in Xenopus oocytes led only to desensitization of expressed rMOR1, but not of an S261A/S266A receptor mutant.
Neg (not) Gene_expression (expressed) of mutant in oocytes
9) Confidence 0.00 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.36

General Comments

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