INT71594

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.07
Pain Relevance 4.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a)
Anatomy Link Frequency
frontal cortex 6
neurons 2
TNC 2
hippocampus 2
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 18 99.92 Very High Very High Very High
Hippocampus 9 99.84 Very High Very High Very High
COX-2 inhibitor 2 99.60 Very High Very High Very High
opioid receptor 8 99.58 Very High Very High Very High
Morphine 32 99.46 Very High Very High Very High
Glutamate receptor 3 96.88 Very High Very High Very High
amygdala 4 95.76 Very High Very High Very High
agonist 3 94.64 High High
qutenza 29 91.80 High High
Pain 5 84.80 Quite High
Disease Link Frequency Relevance Heat
Nociception 17 99.80 Very High Very High Very High
Urological Neuroanatomy 8 99.20 Very High Very High Very High
Headache 6 79.64 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Cluster Headache 2 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data demonstrate that chronic morphine treatment region-specific up-regulates the levels of the alpha-CaMK II gene expression in hippocampus and frontal cortex.
Positive_regulation (up-regulates) of Gene_expression (expression) of alpha-CaMK II in frontal cortex associated with urological neuroanatomy, hippocampus and morphine
1) Confidence 0.47 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.17 Pain Relevance 0.76
Our data showed that repeated, but not single morphine administration, resulted in significant up-regulation of the alpha-CaMK II gene expression in hippocampus and frontal cortex.
Positive_regulation (up-regulation) of Gene_expression (expression) of alpha-CaMK II in frontal cortex associated with urological neuroanatomy, hippocampus and morphine
2) Confidence 0.47 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.10 Pain Relevance 0.65
In our experiments, we demonstrated that pretreatment with NS398, the selective COX-2 inhibitor attenuated the NTG-induced CamKIIalpha expression in the TNC at doses of 3 and 5mg/kg.
Positive_regulation (induced) of Gene_expression (expression) of CamKIIalpha in TNC associated with cox-2 inhibitor
3) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19121366 Disease Relevance 0.07 Pain Relevance 0.26
The aim of our study was to determine if any isoforms of the cyclooxygenase (COX) enzyme might have a role in the NTG-induced increase of CamKIIalpha expression.
Positive_regulation (increase) of Gene_expression (expression) of CamKIIalpha
4) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19121366 Disease Relevance 0.08 Pain Relevance 0.24
To investigate the role of calcium/calmodulin-dependent protein kinase II (CaM kinase II) on mu-opioid receptor desensitization, we coexpressed rMOR1 and constitutively active CaM kinase II in HEK293 cells.
Positive_regulation (coexpressed) of Gene_expression (coexpressed) of kinase II associated with opioid receptor
5) Confidence 0.31 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.38
Our data showed that repeated, but not single morphine administration, resulted in significant up-regulation of the alpha-CaMK II gene expression in hippocampus and frontal cortex.
Positive_regulation (up-regulation) of in hippocampus Gene_expression (expression) of alpha-CaMK II in frontal cortex associated with urological neuroanatomy, hippocampus and morphine
6) Confidence 0.16 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.10 Pain Relevance 0.65
Taken together, our data demonstrate that chronic morphine treatment region-specific up-regulates the levels of the alpha-CaMK II gene expression in hippocampus and frontal cortex.
Positive_regulation (up-regulates) of in hippocampus Gene_expression (expression) of alpha-CaMK II in frontal cortex associated with urological neuroanatomy, hippocampus and morphine
7) Confidence 0.16 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.17 Pain Relevance 0.76
This event produces a large influx of calcium into the nociceptive neurons, activating multiple intracellular protein kinase cascades, such as CaM kinase II, PKC, as well as MAP kinase [2,4,6,18,30-34].
Positive_regulation (activating) of Gene_expression (cascades) of kinase II in neurons associated with nociception and kinase c
8) Confidence 0.15 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.37 Pain Relevance 0.65

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox