INT71595

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Context Info
Confidence 0.04
First Reported 1997
Last Reported 1997
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.69

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plasma membrane (Camk2a) kinase activity (Camk2a) signal transducer activity (Oprm1)
Camk2a (Rattus norvegicus)
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
agonist 6 96.36 Very High Very High Very High
Enkephalin 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the role of calcium/calmodulin-dependent protein kinase II (CaM kinase II) on mu-opioid receptor desensitization, we coexpressed rMOR1 and constitutively active CaM kinase II in HEK293 cells.
kinase II Spec (investigate) Regulation (role) of Spec (investigate) Negative_regulation (desensitization) of mu-opioid receptor associated with opioid receptor
1) Confidence 0.04 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.35
To investigate the role of calcium/calmodulin-dependent protein kinase II (CaM kinase II) on mu-opioid receptor desensitization, we coexpressed rMOR1 and constitutively active CaM kinase II in HEK293 cells.
kinase II Spec (investigate) Regulation (role) of Spec (investigate) Negative_regulation (desensitization) of mu-opioid receptor associated with opioid receptor
2) Confidence 0.04 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9326307 Disease Relevance 0 Pain Relevance 0.35

General Comments

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