INT71602

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 84
Total Number 84
Disease Relevance 67.77
Pain Relevance 3.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
stem cells 5
hepatocytes 4
brain 3
neural 3
neuronal 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 142 99.04 Very High Very High Very High
Somatostatin 87 98.70 Very High Very High Very High
ischemia 66 97.84 Very High Very High Very High
rheumatoid arthritis 113 96.92 Very High Very High Very High
Inflammation 378 96.80 Very High Very High Very High
cytokine 196 95.80 Very High Very High Very High
cINOD 53 94.56 High High
Hippocampus 34 94.16 High High
Arthritis 14 93.52 High High
antagonist 33 93.36 High High
Disease Link Frequency Relevance Heat
Cancer 4058 100.00 Very High Very High Very High
Apoptosis 1493 100.00 Very High Very High Very High
Shock 28 100.00 Very High Very High Very High
Hepatocellular Cancer 301 99.84 Very High Very High Very High
Liver Cancer 117 99.74 Very High Very High Very High
Breast Cancer 151 99.62 Very High Very High Very High
Brain Tumor 1328 99.32 Very High Very High Very High
Targeted Disruption 580 99.08 Very High Very High Very High
Colon Cancer 79 99.08 Very High Very High Very High
Aging 251 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a related study, Gil-Perotin et al., found a p53-dependent effect on differentiationthe and they could determine that loss of p53 increased the number of Tuj1+ neuroblasts in the subventricular zone in vivo [31].
Negative_regulation (loss) of p53 in neuroblasts
1) Confidence 0.59 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.93 Pain Relevance 0
In summary, a number of studies show that the loss of p53 provides an advantage to neural stem cells and/or early progenitor cells [31, 73, 90].
Negative_regulation (loss) of p53 in stem cells
2) Confidence 0.59 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.66 Pain Relevance 0
Also by using olfactory bulb neural stem and progenitor cells cultured as neurospheres it was found, in agreement with the previous studies, that loss of p53 can promote neurosphere formation and stem cell self-renewal [90].
Negative_regulation (loss) of p53 in neural
3) Confidence 0.59 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.75 Pain Relevance 0
Although loss of p53 on its own does not give rise to brain tumors in mice, it allows for rapid tumor development in the presence of persistent mitogen signaling, oncogene activation and subsequent mutational events [32].
Negative_regulation (loss) of p53 in brain associated with cancer and brain tumor
4) Confidence 0.59 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.80 Pain Relevance 0.07
Furthermore, loss of p53 facilitated differentiation of progenitor cells into Tuj1-positive neurons, with a corresponding moderate decrease in mature astrocytes [90].
Negative_regulation (loss) of p53 in astrocytes
5) Confidence 0.59 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.74 Pain Relevance 0
However, the loss of p53 alone does not cause brain tumors within the relatively short life span of Trp53 knockout mice [91].
Negative_regulation (loss) of p53 in brain associated with targeted disruption and brain tumor
6) Confidence 0.59 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.56 Pain Relevance 0
Several lines of evidence in the literature indicate that loss of p53 affects the properties of adult neural stem cells by providing a proliferative advantage [31, 73, 90].
Negative_regulation (loss) of p53 in neural
7) Confidence 0.59 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.72 Pain Relevance 0.07
DADLE blocked both the increase of p53 mRNA and the decrease of p53 protein caused by METH.
Negative_regulation (decrease) of p53
8) Confidence 0.55 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.18 Pain Relevance 0.22
In addition, chemoprevention studies in mice deficient of the p53 tumor-suppressor gene, the most commonly altered gene in human cancer, suggest that the increased susceptibility to cancer resulting from the loss of p53 function may be offset by preventive approaches.
Negative_regulation (loss) of p53 associated with cancer
9) Confidence 0.50 Published 1997 Journal Curr Opin Oncol Section Abstract Doc Link 9327228 Disease Relevance 1.46 Pain Relevance 0.09
Studies show that spontaneous tumour developing due to loss of p53 function may be offset by preventive measures.
Negative_regulation (loss) of p53 associated with cancer
10) Confidence 0.49 Published 2000 Journal Toxicol. Lett. Section Abstract Doc Link 10720773 Disease Relevance 1.06 Pain Relevance 0.13
We conclude that even a slight reduction of p53 function greatly facilitates the ability of MYC to induce tumorigenesis in adult hepatocytes.


Negative_regulation (reduction) of p53 in hepatocytes
11) Confidence 0.44 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.53 Pain Relevance 0
We found that the ability of MYC overexpression to induce tumorigenesis in adult hepatocytes often requires the loss of p53 function.
Negative_regulation (loss) of p53 in hepatocytes
12) Confidence 0.44 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.83 Pain Relevance 0
Since p53 mediates its function largely through inducing the transcription of many different genes, we evaluated if tumors exhibited a loss of p53 function by measuring the expression of these target genes.
Negative_regulation (loss) of p53 associated with cancer
13) Confidence 0.44 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.70 Pain Relevance 0
It was also found that a p53 deficiency in neurospheres resulted in increased self-renewal capacity, increased cell proliferation and a reduction in apoptosis [73].
Negative_regulation (deficiency) of p53 associated with apoptosis
14) Confidence 0.43 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.77 Pain Relevance 0
Interestingly, PTEN is critical in restricting neural stem cell self-renewal and proliferation similar to p53 [119, 120], and the combined loss of p53 and PTEN promotes a synergistic increase in neural stem cell self-renewal associated with elevated levels of c-Myc and rapid growth of gliomas in vivo [27, 121].
Negative_regulation (loss) of p53 in stem cell associated with glioma
15) Confidence 0.43 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.94 Pain Relevance 0.03
Unfortunately, inhibition of p53 activity in nontumorigenic cells could have a procarcinogenic effect, although encouraging results from studies in hematopoietic cells indicate that this might not be the case [161].

7.

Negative_regulation (inhibition) of p53 in hematopoietic cells
16) Confidence 0.43 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.99 Pain Relevance 0.10
Loss of p53 in neural stem cells has in mouse models been proven as an important step in the initiation of gliomas [123].
Negative_regulation (Loss) of p53 in neural associated with glioma
17) Confidence 0.43 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.17 Pain Relevance 0
Whereas activation of p53 traditionally has been viewed as the main avenue, the potential medical applications of inhibiting p53 should also be realized.
Negative_regulation (inhibiting) of p53
18) Confidence 0.43 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.21 Pain Relevance 0.09
In bone formation, the loss of p53 not only accelerates early osteogenesis from mesenchymal stem cells but actually prevents terminal differentiation to a mature osteocytic phenotype [92].
Negative_regulation (loss) of p53 in stem cells
19) Confidence 0.43 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.57 Pain Relevance 0
We review the literature regarding the neoplastic potential of neural stem cells, and we describe how the loss of p53 in parallel with deregulation of growth factor signaling pathways promotes brain tumor development.
Negative_regulation (loss) of p53 in stem cells associated with brain tumor
20) Confidence 0.43 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.35 Pain Relevance 0

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