INT71634

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 45
Total Number 48
Disease Relevance 13.48
Pain Relevance 15.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC6A3) cell death (SLC6A3) aging (SLC6A3)
plasma membrane (SLC6A3) transmembrane transport (SLC6A3) cytoplasm (SLC6A3)
Anatomy Link Frequency
neurons 10
embryonic kidney 4
brain 3
spinal cord 2
striatum 2
SLC6A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1854 100.00 Very High Very High Very High
midbrain 149 100.00 Very High Very High Very High
Serotonin 28 100.00 Very High Very High Very High
isoflurane 42 99.56 Very High Very High Very High
monoamine 59 99.36 Very High Very High Very High
anesthesia 9 99.36 Very High Very High Very High
Spinal cord 572 99.02 Very High Very High Very High
antidepressant 12 98.40 Very High Very High Very High
fluoxetine 6 97.60 Very High Very High Very High
Ventral tegmentum 29 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 12 99.90 Very High Very High Very High
Glioblastoma 2 99.76 Very High Very High Very High
Neuroblastoma 2 99.42 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 131 99.32 Very High Very High Very High
Poisoning 137 98.72 Very High Very High Very High
Parkinson's Disease 496 98.64 Very High Very High Very High
Toxicity 22 98.44 Very High Very High Very High
Hemolysis 48 98.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 98.24 Very High Very High Very High
Death 26 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Isoflurane alters the amount of dopamine transporter expressed on the plasma membrane in humans.
Gene_expression (expressed) of dopamine transporter in plasma associated with dopamine and isoflurane
1) Confidence 0.78 Published 2004 Journal Anesthesiology Section Title Doc Link 15505448 Disease Relevance 0 Pain Relevance 0.43
The data are most easily explained if isoflurane alters the amount of functionally expressed DAT through an indirect pathway.
Gene_expression (expressed) of DAT
2) Confidence 0.78 Published 2004 Journal Anesthesiology Section Body Doc Link 15505448 Disease Relevance 0 Pain Relevance 0
The chronic use of heroin was significantly associated with decreased DAT mRNA expression localized to the paranigral nucleus (PN) and the mesolimbic division of the ventral tegmental area (VTA) with no alterations in nigrostriatal populations.
Gene_expression (expression) of DAT mRNA in ventral associated with ventral tegmentum
3) Confidence 0.70 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.30 Pain Relevance 0.42
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Gene_expression (expression) of DA transporter associated with dopamine and opiate addiction
4) Confidence 0.70 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.24 Pain Relevance 0.41
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Gene_expression (expression) of DAT associated with dopamine and opiate addiction
5) Confidence 0.70 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.24 Pain Relevance 0.41
Significant alteration of the mRNA expression of Nurr1, a transcription factor that regulates DAT expression, was also confined to the PN.
Gene_expression (expression) of DAT
6) Confidence 0.70 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.40 Pain Relevance 0.58
The present investigation was undertaken to demonstrate quantitatively the isoflurane-induced internalization of DAT using a rapid and relatively uncomplicated biochemical technique in human embryonic kidney (HEK-293) cells stably expressing the human DAT (h-DAT) protein.
Gene_expression (expressing) of h-DAT in embryonic kidney associated with isoflurane
7) Confidence 0.68 Published 2004 Journal Synapse Section Abstract Doc Link 15170819 Disease Relevance 0 Pain Relevance 0.49
The present investigation was undertaken to demonstrate quantitatively the isoflurane-induced internalization of DAT using a rapid and relatively uncomplicated biochemical technique in human embryonic kidney (HEK-293) cells stably expressing the human DAT (h-DAT) protein.
Gene_expression (expressing) of DAT in embryonic kidney associated with isoflurane
8) Confidence 0.68 Published 2004 Journal Synapse Section Abstract Doc Link 15170819 Disease Relevance 0 Pain Relevance 0.49
Because others have shown that compounds can exhibit Kiuptake/Kibind ratios greater than unity when the assays are performed under non-identical conditions, we have established these assays under identical conditions of time, temperature and buffer using a Chinese hamster ovary (CHO) cell line which stably expresses the human DAT.
Gene_expression (expresses) of DAT in ovary
9) Confidence 0.65 Published 1997 Journal Drug Alcohol Depend Section Abstract Doc Link 9330920 Disease Relevance 0 Pain Relevance 0.62
This is so because the abuse potential of MPH is thought to be due to the rapid onset of blockade of the presynaptic dopamine transporter (DAT) in the brain [22].
Gene_expression (presynaptic) of DAT in brain associated with dopamine
10) Confidence 0.65 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2075491 Disease Relevance 0.37 Pain Relevance 0.08
Neuroblastoma and glioblastoma cell lines expressing the dopamine transporter, as well as primary macrophages exposed to human immunodeficiency virus-1 (HIV-1), were used to investigate the possibility of any synergistic effect between the mode of toxicity of such substances and virus exposure.
Gene_expression (expressing) of dopamine transporter in macrophages associated with toxicity, neuroblastoma, dopamine, glioblastoma and acquired immune deficiency syndrome or hiv infection
11) Confidence 0.65 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9372455 Disease Relevance 0.93 Pain Relevance 0.28
The findings summarized by Huang (2007) are consistent with a normal synthesis of dopamine and normal levels of DAT, both of which are significantly decreased in PD patients (Table 2).
Gene_expression (levels) of DAT associated with dopamine and disease
12) Confidence 0.58 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 1.00 Pain Relevance 0.45
This transient increase is most likely due to acute inhibition of DAT, which produces an up-regulation of the protein.
Gene_expression (produces) of DAT
13) Confidence 0.58 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.29 Pain Relevance 0.21
We had shown both in subjects with ADHD and in healthy controls a positive correlation between DAT availability in striatum and inattention [15].
Gene_expression (availability) of DAT in striatum associated with attention deficit hyperactivity disorder
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.55 Pain Relevance 0.30
Thus, higher striatal DAT levels, which would result in an enhanced clearance of dopamine and hence weaker dopamine signals, would be associated to lower deactivation in the DMN during an attention task.


Gene_expression (levels) of DAT associated with dopamine
15) Confidence 0.58 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.42
Biotinylation followed by Western blot analysis was used to determine the extent of change in cell surface expression of the DAT under control conditions and in the presence of a clinically relevant concentration of isoflurane.
Gene_expression (expression) of DAT associated with isoflurane
16) Confidence 0.53 Published 2004 Journal Synapse Section Abstract Doc Link 15170819 Disease Relevance 0 Pain Relevance 0.48
Thus future studies with markers that can differentiate between DA terminal innervation and DAT expression per terminal are necessary to confirm our findings. 2) The relatively small sample size (N?
Gene_expression (expression) of DAT associated with dopamine
17) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.30 Pain Relevance 0.31
In a preliminary report in which four Mn-exposed animal were used, they found no significant effect of Mn exposure (mean cumulative Mn dose, 165.5 mg Mn/kg body weight; range, 152–174 mg Mn/kg body weight) on DAT or D2R receptor levels using autoradiography or tyrosine hydroxylase immunohistochemistry, or on the concentration of dopamine and its metabolite homovanillic acid (HVA) measured by HPLC with electrochemical detection in the caudate or putamen, relative to naive controls (Guilarte et al. 2006a).
Gene_expression (levels) of DAT in putamen associated with dopamine and body weight
18) Confidence 0.50 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.20 Pain Relevance 0.28
Thirty-one priority genes have been previously designated PD candidate genes (http://www.pdgene.org/) (SI_Table_1f), and it is worth noting that 33 are considered AD candidate genes as well (SI_Table_1g) with HSPA1A, HSPA1B, HTR2A, KCNJ6, SLC6A3, SNCA, SNCG, TF and UCHL1 being present in both lists.
Gene_expression (present) of SLC6A3 associated with disease
19) Confidence 0.38 Published 2008 Journal Neurogenetics Section Body Doc Link PMC2238789 Disease Relevance 0.32 Pain Relevance 0
Finally, A11 neurons do not express DAT.
Neg (not) Gene_expression (express) of DAT in A11
20) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.45 Pain Relevance 0.39

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