INT71642

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Context Info
Confidence 0.20
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-A, PMEL) endosome (PMEL) extracellular region (PMEL)
Golgi apparatus (PMEL) endoplasmic reticulum (PMEL)
Anatomy Link Frequency
melanocyte 2
HLA-A (Homo sapiens)
PMEL (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 4 92.32 High High
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 33 100.00 Very High Very High Very High
Cancer 29 81.60 Quite High
Alagille Syndrome 1 66.68 Quite High
Hypopigmentation 14 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 8 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human melanoma-specific HLA-A2 restricted CTLs have recently been shown to recognize antigens expressed by melanoma lines and normal melanocytes, including Melan-A/Mart-1, gp100, gp75, and tyrosinase.
HLA-A2 Binding (recognize) of gp100 in melanocytes associated with melanoma
1) Confidence 0.20 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9331097 Disease Relevance 0.36 Pain Relevance 0.26
In addition, gp100-in4 binds to HLA-A*2402 with high affinity and thus might be very efficiently processed and present on the melanoma and melanocyte cell surface.
HLA-A*2402 Spec (might) Binding (binds) of gp100-in4 in melanocyte associated with melanoma
2) Confidence 0.07 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.69 Pain Relevance 0

General Comments

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