INT71644

Context Info Confidence 0.75 First Reported 1997 Last Reported 2010 Negated 3 Speculated 0 Reported most in Abstract Documents 16 Total Number 16 Disease Relevance 11.55 Pain Relevance 1.82

Golgi apparatus (MLANA) endoplasmic reticulum (MLANA)

Anatomy Link Frequency melanocytes 3 smooth muscle 2 muscle 1 kidney 1 MLANA (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 4 92.52 melanocortin 1 receptor 66 91.76 anesthesia 2 90.64 abdominal pain 4 90.20 Hypoesthesia 1 80.20 cva 2 76.32 agonist 8 73.88 Spinal cord 2 73.20 positron emission tomography 1 44.40 Thoracotomy 1 14.60

Disease Link Frequency Relevance Heat Melanoma 209 100.00 Skin Cancer 31 100.00 Lymphatic System Cancer 8 100.00 Carcinoma 6 100.00 Gastrointestinal Stromal Tumor 1 100.00 Cancer 172 99.34 Necrosis 3 98.32 Tuberous Sclerosis 2 96.88 Rhinitis 5 96.52 Rectal Cancer 2 94.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Human melanoma-specific HLA-A2 restricted CTLs have recently been shown to recognize antigens expressed by melanoma lines and normal melanocytes, including Melan-A/Mart-1, gp100, gp75, and tyrosinase.

Gene_expression (expressed) of Mart-1 in melanocytes associated with melanoma

1) Confidence 0.75 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9331097 Disease Relevance 0.36 Pain Relevance 0.26

In this regard too, the present tumor had a unique immunoprofile, as S-100, HMB45 and Melan-A were all negative in both the core needle and incisional biopsies.

Neg (negative) Gene_expression (negative) of Melan-A associated with cancer

2) Confidence 0.75 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 1.56 Pain Relevance 0

Immunohistochemically, the tumor cells were positive for HMB-45, Melan-A and muscle-specific actin, but negative for epithelial markers, desmin, S-100 protein, and neuroendocrine markers.

Neg (negative) Gene_expression (negative) of Melan-A in muscle associated with cancer

3) Confidence 0.75 Published 2007 Journal APMIS Section Abstract Doc Link 18184420 Disease Relevance 0.54 Pain Relevance 0.09

By IMHC, the cells were positive for inhibin, melan-A, and synaptophysin, and negative for GFAP, EMA, cytokeratins, S-100, HMB-45, and chromogranin.

Neg (negative) Gene_expression (positive) of melan-A

4) Confidence 0.65 Published 2004 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15306940 Disease Relevance 0.90 Pain Relevance 0.15

It promotes transcription of melanocyte-specific gene products including melanosomal enzymes tyrosinase, TYRP1 and DCT and the matrix protein SILV/PMEL (Levy et al., 2006).

Gene_expression (products) of melan in melanocyte

5) Confidence 0.65 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.18 Pain Relevance 0.38

ASIP-YY displaces NDP-MSH from human melanocortin receptors expressed on HEK-293 human kidney cells, and inhibits ?

Gene_expression (expressed) of melan in kidney

6) Confidence 0.58 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.08

The immunohistochemical stains for melanoma (S100, tyrosinase, Melan A and HMB-45), carcinoma (CK), gastrointestinal stromal tumours (CD-34, vimentin and c-Kit) and lymphoma (LCA) were performed with negative results, except for a weak and focal expression of vimentin.

Gene_expression (expression) of Melan A associated with lymphatic system cancer, melanoma, carcinoma and gastrointestinal stromal tumor

7) Confidence 0.58 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396655 Disease Relevance 1.65 Pain Relevance 0.06

One should always check for protein S-100, melanoma antigen HMN-45 and Melan-A expression, as they are strongly suggestive of melanoma.

Gene_expression (expression) of Melan-A associated with skin cancer

8) Confidence 0.58 Published 2008 Journal Acta Chir. Belg. Section Abstract Doc Link 19241934 Disease Relevance 1.44 Pain Relevance 0.06

Human melanoma-specific HLA-A2 restricted CTLs have recently been shown to recognize antigens expressed by melanoma lines and normal melanocytes, including Melan-A/Mart-1, gp100, gp75, and tyrosinase.

Gene_expression (expressed) of Melan-A in melanocytes associated with melanoma

9) Confidence 0.58 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9331097 Disease Relevance 0.36 Pain Relevance 0.26

Unusual complex phenotype included co-expression of vimentin, smooth muscle actin, desmin, HMB45, Melan A, CD10 and EMA.

Gene_expression (-) of Melan A in smooth muscle

10) Confidence 0.58 Published 2007 Journal Cesk Patol Section Abstract Doc Link 17821838 Disease Relevance 0.91 Pain Relevance 0.11

Unusual complex phenotype included co-expression of vimentin, smooth muscle actin, desmin, HMB45, Melan A, CD10 and EMA.

Gene_expression (expression) of Melan A in smooth muscle

11) Confidence 0.58 Published 2007 Journal Cesk Patol Section Abstract Doc Link 17821838 Disease Relevance 0.91 Pain Relevance 0.11

Biopsies proved it to be an amelanotic malignant melanoma, as protein S100, melanoma antigen HMB45 and Melan-A expression were found.

Gene_expression (expression) of Melan-A associated with skin cancer

12) Confidence 0.58 Published 2008 Journal Acta Chir. Belg. Section Abstract Doc Link 19241934 Disease Relevance 1.14 Pain Relevance 0.09

In accordance with the microarray, qPCR, and western blot data, immunofluoresence suggested differential expression of both MITF and MLANA in representative Motif 1 and 2 NZM cells, with strong nuclear signal for MITF and strong cytoplasmic signal for MLANA in NZM06 compared to NZM09 (Figure 1D).

Gene_expression (expression) of MLANA

13) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.12 Pain Relevance 0

In accordance with the microarray, qPCR, and western blot data, immunofluoresence suggested differential expression of both MITF and MLANA in representative Motif 1 and 2 NZM cells, with strong nuclear signal for MITF and strong cytoplasmic signal for MLANA in NZM06 compared to NZM09 (Figure 1D).

Gene_expression (expression) of MLANA

14) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.18 Pain Relevance 0

Characterization of these cells using confocal microscopy, FACs analysis and western blotting showed that they expressed melanoma-associated antigens; Melan-A, MAGE-1, and MAGE-3, and PCNA expression was higher in fast-proliferating isolates.

Gene_expression (expression) of Melan-A associated with melanoma

15) Confidence 0.26 Published 2009 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 19057970 Disease Relevance 1.02 Pain Relevance 0.08

Minimally invasive staging of patients with melanoma: sentinel lymphadenectomy and detection of the melanoma-specific proteins MART-1 and tyrosinase by reverse transcriptase polymerase chain reaction.

Gene_expression (detection) of MART-1 associated with skin cancer

16) Confidence 0.24 Published 1998 Journal J. Am. Coll. Surg. Section Title Doc Link 9704966 Disease Relevance 0.29 Pain Relevance 0.09

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