INT71644
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Human melanoma-specific HLA-A2 restricted CTLs have recently been shown to recognize antigens expressed by melanoma lines and normal melanocytes, including Melan-A/Mart-1, gp100, gp75, and tyrosinase. | |||||||||||||||
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In this regard too, the present tumor had a unique immunoprofile, as S-100, HMB45 and Melan-A were all negative in both the core needle and incisional biopsies. | |||||||||||||||
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Immunohistochemically, the tumor cells were positive for HMB-45, Melan-A and muscle-specific actin, but negative for epithelial markers, desmin, S-100 protein, and neuroendocrine markers. | |||||||||||||||
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By IMHC, the cells were positive for inhibin, melan-A, and synaptophysin, and negative for GFAP, EMA, cytokeratins, S-100, HMB-45, and chromogranin. | |||||||||||||||
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It promotes transcription of melanocyte-specific gene products including melanosomal enzymes tyrosinase, TYRP1 and DCT and the matrix protein SILV/PMEL (Levy et al., 2006). | |||||||||||||||
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ASIP-YY displaces NDP-MSH from human melanocortin receptors expressed on HEK-293 human kidney cells, and inhibits ? | |||||||||||||||
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The immunohistochemical stains for melanoma (S100, tyrosinase, Melan A and HMB-45), carcinoma (CK), gastrointestinal stromal tumours (CD-34, vimentin and c-Kit) and lymphoma (LCA) were performed with negative results, except for a weak and focal expression of vimentin. | |||||||||||||||
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One should always check for protein S-100, melanoma antigen HMN-45 and Melan-A expression, as they are strongly suggestive of melanoma. | |||||||||||||||
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Human melanoma-specific HLA-A2 restricted CTLs have recently been shown to recognize antigens expressed by melanoma lines and normal melanocytes, including Melan-A/Mart-1, gp100, gp75, and tyrosinase. | |||||||||||||||
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Unusual complex phenotype included co-expression of vimentin, smooth muscle actin, desmin, HMB45, Melan A, CD10 and EMA. | |||||||||||||||
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Unusual complex phenotype included co-expression of vimentin, smooth muscle actin, desmin, HMB45, Melan A, CD10 and EMA. | |||||||||||||||
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Biopsies proved it to be an amelanotic malignant melanoma, as protein S100, melanoma antigen HMB45 and Melan-A expression were found. | |||||||||||||||
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In accordance with the microarray, qPCR, and western blot data, immunofluoresence suggested differential expression of both MITF and MLANA in representative Motif 1 and 2 NZM cells, with strong nuclear signal for MITF and strong cytoplasmic signal for MLANA in NZM06 compared to NZM09 (Figure 1D).
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In accordance with the microarray, qPCR, and western blot data, immunofluoresence suggested differential expression of both MITF and MLANA in representative Motif 1 and 2 NZM cells, with strong nuclear signal for MITF and strong cytoplasmic signal for MLANA in NZM06 compared to NZM09 (Figure 1D).
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Characterization of these cells using confocal microscopy, FACs analysis and western blotting showed that they expressed melanoma-associated antigens; Melan-A, MAGE-1, and MAGE-3, and PCNA expression was higher in fast-proliferating isolates. | |||||||||||||||
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Minimally invasive staging of patients with melanoma: sentinel lymphadenectomy and detection of the melanoma-specific proteins MART-1 and tyrosinase by reverse transcriptase polymerase chain reaction. | |||||||||||||||
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