INT7168

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Context Info
Confidence 0.70
First Reported 1983
Last Reported 1992
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.30
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) response to stress (Ctsb) lysosome (Ctsb)
Anatomy Link Frequency
muscle 1
cleavage 1
fibroblasts 1
Ctsb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 161 99.84 Very High Very High Very High
Enkephalin 42 99.48 Very High Very High Very High
antagonist 14 98.80 Very High Very High Very High
local anesthetic 2 91.40 High High
fibrosis 1 89.64 High High
Chronic pancreatitis 1 87.00 High High
Disease Link Frequency Relevance Heat
Fibrosis 1 89.64 High High
Pancreatitis 1 87.00 High High
Alcoholic Pancreatitis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Degenerating muscle showed a spotty fluorescence when stained with antibodies against cathepsin B, indicating that the increased cathepsin B did not originate from the muscle itself, but from invading phagocytes.
Neg (not) Positive_regulation (increased) of cathepsin B in muscle
1) Confidence 0.70 Published 1983 Journal J. Biochem. Section Abstract Doc Link 6619116 Disease Relevance 0 Pain Relevance 0.17
The activation of cathepsin B by those stimulants was dependent on calcium ion.
Positive_regulation (activation) of cathepsin B
2) Confidence 0.55 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.15
Activation of cathepsin B involved in enkephalin production by bradykinin and its cleavage products in cultured fibroblasts of the rat dental pulp.
Positive_regulation (Activation) of cathepsin B in cleavage associated with enkephalin and bradykinin
3) Confidence 0.55 Published 1992 Journal J Osaka Univ Dent Sch Section Title Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.12
On the other hand, the activation of cathepsin B was inhibited by neomycin B (phospholipase C inhibitor) and various serine/threonine kinase inhibitors.
Positive_regulation (activation) of cathepsin B
4) Confidence 0.55 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.14
Cathepsin B activation by BK or L-Arg but not des-Arg9-BK was inhibited by L-NMMA (inhibitor of NO synthesis), and the activation by L-Arg was enhanced by beta-glycerophosphate (beta-GP: inhibitor of phosphatases), while the activation by BK or des-Arg9-BK was inhibited by beta-GP.
Positive_regulation (activation) of Cathepsin B associated with bradykinin
5) Confidence 0.40 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 0.85
These results suggest that BK-induced cathepsin B activation in the fibroblasts may be due to a combined effect of des-Arg9-BK and L-Arg.
Positive_regulation (activation) of cathepsin B in fibroblasts associated with bradykinin
6) Confidence 0.40 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 0.66
These results suggest that the ME production by BK or des-Arg9-BK may be mediated by Ca(2+)-dependent cathepsin B activation through B1-receptors and IAP-sensitive G-proteins, whereas the production by L-Arg may be mediated by Ca(2+)-dependent cathepsin B activation through kyotorphin-receptor and Botulinum C3-enzyme-sensitive G-proteins.
Positive_regulation (activation) of cathepsin B associated with enkephalin and bradykinin
7) Confidence 0.40 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.18
These results suggest that the ME production by BK or des-Arg9-BK may be mediated by Ca(2+)-dependent cathepsin B activation through B1-receptors and IAP-sensitive G-proteins, whereas the production by L-Arg may be mediated by Ca(2+)-dependent cathepsin B activation through kyotorphin-receptor and Botulinum C3-enzyme-sensitive G-proteins.
Positive_regulation (activation) of cathepsin B associated with enkephalin and bradykinin
8) Confidence 0.40 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.18
While acid phosphatase was increased in all of the particulate fractions, cathepsin B was increased in the zymogen granule and mitochondrial-lysosomal fractions.
Positive_regulation (increased) of cathepsin B
9) Confidence 0.29 Published 1987 Journal Int. J. Pancreatol. Section Abstract Doc Link 2447206 Disease Relevance 0.30 Pain Relevance 0.13

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