INT71680

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 43
Total Number 47
Disease Relevance 33.70
Pain Relevance 18.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCL3) extracellular space (CCL3) extracellular region (CCL3)
intracellular (CCL3) cytoskeleton organization (CCL3) kinase activity (CCL3)
Anatomy Link Frequency
macrophage 6
plasma 4
microglia 3
epithelium 2
myocardium 1
CCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 975 100.00 Very High Very High Very High
Inflammation 709 100.00 Very High Very High Very High
cytokine 270 100.00 Very High Very High Very High
mu opioid receptor 4 99.96 Very High Very High Very High
Arthritis 665 99.84 Very High Very High Very High
Nerve growth factor 46 99.80 Very High Very High Very High
rheumatoid arthritis 428 99.78 Very High Very High Very High
bradykinin 12 99.42 Very High Very High Very High
neuralgia 1 98.80 Very High Very High Very High
methotrexate 141 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 756 100.00 Very High Very High Very High
Cancer 63 100.00 Very High Very High Very High
Necrosis 56 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 402 99.84 Very High Very High Very High
Critical Illness 148 99.84 Very High Very High Very High
Rheumatoid Arthritis 434 99.78 Very High Very High Very High
Arthritis 140 99.54 Very High Very High Very High
Disease 348 99.14 Very High Very High Very High
Infection 222 99.14 Very High Very High Very High
Stress 9 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting to note that expression of IP-10, MIP-1alpha, and MCP-1 is high in healthy pancreatic tissue but low in tissue of patients with CP, suggesting a mutually exclusive expression of the ELR-CXC vs. non-ELR-CXC/CC chemokines.
Gene_expression (expression) of MIP-1alpha associated with chemokine and chronic pancreatitis
1) Confidence 0.75 Published 1997 Journal J. Leukoc. Biol. Section Abstract Doc Link 9365115 Disease Relevance 0.73 Pain Relevance 0.61
It is shown that E-selectin, sLe(x), and MIP-1alpha are synthesized and expressed by epithelial cells, indicating that CAMs are not only involved in leukocyte extravasation and migration, but also in the interaction between leukocytes and colonic epithelium.
Gene_expression (expressed) of MIP-1alpha in epithelium
2) Confidence 0.75 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539657 Disease Relevance 0.79 Pain Relevance 0.14
It is shown that E-selectin, sLe(x), and MIP-1alpha are synthesized and expressed by epithelial cells, indicating that CAMs are not only involved in leukocyte extravasation and migration, but also in the interaction between leukocytes and colonic epithelium.
Gene_expression (synthesized) of MIP-1alpha in epithelium
3) Confidence 0.75 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539657 Disease Relevance 0.79 Pain Relevance 0.14
Moreover, increased expression of the CCR5 ligand, MIP-1a/CCL3, in humans (as a result of gene duplication) provides protection from HIV acquisition (Gonzalez et al 2005).
Gene_expression (expression) of MIP-1a associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.75 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.55 Pain Relevance 0.20
In relation to the etiology of this bone destruction, it has been reported recently that MIP-1alpha, produced in large amounts in myeloma patients, acts indirectly on osteoclastic precursor cells, and activates osteoclasts by way of bone-marrow stromal cells or osteoblasts, although the details of this process remain obscure.
Gene_expression (produced) of MIP-1alpha in osteoblasts associated with osteoporosis
5) Confidence 0.75 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.36 Pain Relevance 0.13
Significantly higher levels of MIP-1alpha and IL-8 were detected in patients with H. pylori infection than in those without infection.
Gene_expression (detected) of MIP-1alpha associated with infection
6) Confidence 0.75 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872512 Disease Relevance 1.15 Pain Relevance 0.23
We examined the relationship between the levels of macrophage inflammatory protein 1alpha (MIP-1alpha) and interleukin-8 (IL-8) in organ cultures of antral mucosal tissues, background gastroduodenal diseases, and grades of histologic gastritis.
Gene_expression (levels) of MIP-1alpha in macrophage associated with inflammation, gastritis and disease
7) Confidence 0.75 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872512 Disease Relevance 0.94 Pain Relevance 0.16
Our investigations have demonstrated that HIV infection of macrophages stimulate considerably the synthesis of MIP-1-alpha, MIP-1-beta RANTES chemokines (subgroup CC).
Gene_expression (synthesis) of MIP-1-alpha in macrophages associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
8) Confidence 0.61 Published 1997 Journal Bratisl Lek Listy Section Abstract Doc Link 9333424 Disease Relevance 2.35 Pain Relevance 0.20
Stimuli for sTNF production also include chemokines or cytokines (CCL3, IL-1) and also cellular stress responses such as hypoxia, oxygen radicals, and temperature shock.
Gene_expression (production) of CCL3 associated with stress, chemokine, hypoxia, shock and cytokine
9) Confidence 0.58 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.76 Pain Relevance 0.14
Inflammation mediators, mainly proinflammatory cytokines (IL1, TNF-alpha), chemokines (IL6, IL8 and MIP-1alpha) and immunomodulator cytokines (IL6) and immunosuppressive cytokines (IL10, IL4) are produced by the amniotic and decidual membranes and are found in the fetal circulation and amniotic fluid.
Gene_expression (produced) of MIP-1alpha in amniotic fluid associated with chemokine, inflammation and cytokine
10) Confidence 0.58 Published 2001 Journal J Gynecol Obstet Biol Reprod (Paris) Section Abstract Doc Link 11240512 Disease Relevance 1.14 Pain Relevance 0.59
The expression levels of the majority of genes (>95%) did not vary over time or with exposure to different biomaterials, but a few important genes, such as TNF-alpha, IL-1beta, IL-6, and MIP1alpha, proved to be highly regulated in response to biomaterial exposure.
Gene_expression (expression) of MIP1alpha
11) Confidence 0.58 Published 2005 Journal Biomaterials Section Abstract Doc Link 15603788 Disease Relevance 0.29 Pain Relevance 0.09
Colonic expression of E-selectin, sialyl Lewis X (sLe(x)), and macrophage inflammatory protein-1x (MIP-1alpha) as well as serum concentrations of E-selectin and MIP-1alpha in UC were studied.
Gene_expression (expression) of MIP-1alpha in macrophage associated with inflammatory bowel disease and inflammation
12) Confidence 0.58 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539657 Disease Relevance 0.95 Pain Relevance 0.18
The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Gene_expression (levels) of CCL3 in plasma associated with disease
13) Confidence 0.55 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.59 Pain Relevance 0.07
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Gene_expression (levels) of CCL3 in lung associated with chemokine and cytokine
14) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.55 Pain Relevance 0.14
Levels of CCL5, CCL3 and CXCL10 were measured in plasma and SF samples after only one thaw.
Gene_expression (Levels) of CCL3 in plasma
15) Confidence 0.55 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0 Pain Relevance 0.19
/CCL3 and MIP-1?
Gene_expression (/) of CCL3
16) Confidence 0.51 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 1.32 Pain Relevance 0.83
/CCL3 and MIP-1?
Gene_expression (/) of CCL3
17) Confidence 0.51 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.21 Pain Relevance 0.08
/CCL3 and MIP-1?
Gene_expression (/) of CCL3
18) Confidence 0.51 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.26 Pain Relevance 0.10
The disease severity correlated with significant increase in IL1RA, IL2, IL6, CCL3, CCL4 and IL10 levels in critically ill patients.


Gene_expression (levels) of CCL3 associated with critical illness and disease
19) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.89 Pain Relevance 0.09
We demonstrate that the chemokines CCL5 (RANTES) and CCL3 (also known as macrophage inflammatory protein (MIP)-1?)
Gene_expression (demonstrate) of CCL3 in macrophage associated with chemokine and inflammation
20) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 1.11 Pain Relevance 0.72

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