INT71689

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 26
Disease Relevance 11.10
Pain Relevance 7.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
brain 5
outflow 2
spinal cord 2
fibroblasts 2
neurons 2
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 171 100.00 Very High Very High Very High
neurotrophin 3 23 100.00 Very High Very High Very High
Somatostatin 7 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
bDMF 28 99.90 Very High Very High Very High
Spinal cord 533 99.68 Very High Very High Very High
Inflammation 69 99.12 Very High Very High Very High
antidepressant 8 99.04 Very High Very High Very High
Endep 7 98.76 Very High Very High Very High
substance P 6 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 12 100.00 Very High Very High Very High
Frailty 5 99.68 Very High Very High Very High
Glioblastoma 2 99.56 Very High Very High Very High
INFLAMMATION 96 99.12 Very High Very High Very High
Contusions 19 98.96 Very High Very High Very High
Injury 482 98.90 Very High Very High Very High
Diabetes Mellitus 71 98.88 Very High Very High Very High
Neurodegenerative Disease 18 97.96 Very High Very High Very High
Hyperalgesia 16 97.86 Very High Very High Very High
Urinary Dysfunction 16 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although finding that NGF-induced hyperalgesia does not clearly correlate with changes in the release of SP-LI in the spinal cord, this study shows that NT-3 is an inhibitor of SP-LI release and suggests that this mechanism may be responsible for NT-3-induced antinociception.
Localization (release) of NT-3 in spinal cord associated with antinociception, hyperalgesia and spinal cord
1) Confidence 0.73 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9334418 Disease Relevance 0.42 Pain Relevance 0.75
In contrast, neurotrophin-3 (NT-3; 1-100 ng/ml), although not modifying SP-LI basal outflow, dose-dependently inhibited the electrically evoked, but not capsaicin (10 nM)-induced, release of the peptide.
Localization (release) of NT-3 in outflow associated with qutenza
2) Confidence 0.69 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9334418 Disease Relevance 0.07 Pain Relevance 0.46
In contrast, neurotrophin-3 (NT-3; 1-100 ng/ml), although not modifying SP-LI basal outflow, dose-dependently inhibited the electrically evoked, but not capsaicin (10 nM)-induced, release of the peptide.
Localization (release) of neurotrophin-3 in outflow associated with qutenza
3) Confidence 0.69 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9334418 Disease Relevance 0.07 Pain Relevance 0.46
There is also evidence that microglia are capable of secreting neurotrophic or neuron survival factors (e.g. nerve growth factor and neurotrophin 3) upon activation via inflammation or injury [35].
Localization (secreting) of neurotrophin 3 in neuron associated with inflammation, neurotrophin 3, nerve growth factor and injury
4) Confidence 0.68 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 0.66 Pain Relevance 0.35
Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.
Localization (secrete) of NT-3 in oligodendrocytes associated with nerve growth factor
5) Confidence 0.64 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.62 Pain Relevance 0.78
At 6 weeks postoperative, the experimental group received grafts of a combination of fibroblasts modified to secrete BDNF or NT-3.
Localization (secrete) of NT-3 in fibroblasts
6) Confidence 0.60 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14637085 Disease Relevance 0.40 Pain Relevance 0.07
Delayed transplantation of fibroblasts genetically modified to secrete BDNF and NT-3 into a spinal cord injury site is associated with limited recovery of function.
Localization (secrete) of NT-3 in spinal cord associated with spinal cord
7) Confidence 0.60 Published 2003 Journal Exp. Neurol. Section Title Doc Link 14637085 Disease Relevance 0.43 Pain Relevance 0.10
In animals grafted with the control cell line, quinolinate injection induced a gradual cell loss that was differentially prevented by intrastriatal grafting of BDNF-, NT-3-, or NT-415-secreting cells.
Localization (secreting) of NT-3
8) Confidence 0.60 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11183872 Disease Relevance 0.32 Pain Relevance 0.20
Glutamic acid decarboxylase 67-, preproenkephalin-, and preprotachykinin A- but not prodynorphin-expressing neurons were protected by grafting of NT-3- or NT-4/5-secreting cells but with less efficiency than the BDNF-secreting cells.
Localization (secreting) of NT-3 in neurons
9) Confidence 0.60 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11183872 Disease Relevance 0.27 Pain Relevance 0.24
It has been shown that OECs secrete neurotrophic factors (NTFs), including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3/4 (NT-3/4), and ciliary neurotrophic factor (CNTF).
Localization (secrete) of neurotrophin-3 in brain associated with nerve growth factor
10) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.40 Pain Relevance 0.17
It has been shown that OECs secrete neurotrophic factors (NTFs), including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3/4 (NT-3/4), and ciliary neurotrophic factor (CNTF).
Localization (secrete) of NT-3 in brain associated with nerve growth factor
11) Confidence 0.51 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.41 Pain Relevance 0.17
With regard to protein expression, Figure 1D shows a representative ELISA measurement of NT3 secretion by the different hMSC lines used in this study and Figure 1E shows a representative flow cytometric analysis of EGFP expression by the EGFP expressing hMSC lines used in this study.


Localization (secretion) of NT3
12) Confidence 0.46 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.18 Pain Relevance 0.04
Similarly, NT-3 contents were significantly decreased in the saline-injected side of STZ-induced diabetic rats (271 ± 46 pg/mg protein, P = 0.0020) compared with those of normal rats (555 ± 161 pg/mg protein), and transplantation of MSCs did not show any effects on the NT-3 contents (Fig. 4B).


Localization (decreased) of NT-3 associated with neurotrophin 3 and diabetes mellitus
13) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.48 Pain Relevance 0.27
It has been shown that OECs secrete neurotrophic factors (NTFs), including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3/4 (NT-3/4), and ciliary neurotrophic factor (CNTF).
Localization (secrete) of neurotrophic factor in brain associated with nerve growth factor
14) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.42 Pain Relevance 0.17
It has been shown that OECs secrete neurotrophic factors (NTFs), including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3/4 (NT-3/4), and ciliary neurotrophic factor (CNTF).
Localization (secrete) of neurotrophic factor in brain associated with nerve growth factor
15) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.40 Pain Relevance 0.17
Mitsui et al. [21] has made a modified moderate contusion model, the same model in our study, where BDNF and NT-3 secreting fibroblasts were transplanted into the spinal cord and found that the neurogenic bladder was partially improved showing decrement of detrusor pressure and hyperreflexia 56 days following transplantation.
Localization (secreting) of NT-3 in fibroblasts associated with urinary dysfunction, abnormal reflex, overactive bladder, contusions, bdmf and spinal cord
16) Confidence 0.33 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2955046 Disease Relevance 1.27 Pain Relevance 0.44
Neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4, are a family of secreted growth factors that promote the survival, differentiation and maintenance of specific neuronal populations and regulate activity-dependent synaptic plasticity (reviewed in Bibel and Barde, 2000).
Localization (secreted) of neurotrophin-3 in brain associated with nerve growth factor
17) Confidence 0.33 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.57 Pain Relevance 0.34
This observation was attributed to the action of secreted neurotrophic factors such as neurotrophin-3, cell-attached plasma membrane molecules, and possible activation of microglia/macrophages by implanted dendritic cells [36].
Localization (secreted) of neurotrophin-3 in microglia
18) Confidence 0.32 Published 2007 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1876804 Disease Relevance 0.48 Pain Relevance 0.04
A further possible mechanism by which guanosine might exert its neuroprotective effects is by stimulating cells to release and increase synthesis of various trophic factors, such as basic fibroblast growth factor (bFGF), nerve growth factor (NGF), and neurotrophin-3 (NT-3) [28].
Localization (release) of neurotrophin-3 in nerve associated with nerve growth factor
19) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072916 Disease Relevance 0.63 Pain Relevance 0.19
SCs promote axonal regeneration by secretion of adhesion molecules such as L1 and N-CAM, extracellular matrix molecules such as collagen [72] and laminin (see Chernousov and Carey [73] for review), and a number of trophic factors such as FGF-2 [74], nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and NT3 (see Mirsky et al [75] for review).
Localization (secretion) of NT3 in extracellular matrix associated with nerve growth factor and adhesions
20) Confidence 0.26 Published 2007 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1876804 Disease Relevance 0.19 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox