INT717

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Context Info
Confidence 0.61
First Reported 1978
Last Reported 2010
Negated 16
Speculated 4
Reported most in Abstract
Documents 29
Total Number 33
Disease Relevance 17.46
Pain Relevance 6.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
plasma 6
platelet 5
liver 3
blood 1
artery 1
F2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 11 99.84 Very High Very High Very High
acular 10 99.82 Very High Very High Very High
Paracetamol 22 99.62 Very High Very High Very High
Angina 10 99.28 Very High Very High Very High
aspirin 12 98.82 Very High Very High Very High
Inflammation 2 98.36 Very High Very High Very High
lidocaine 5 98.24 Very High Very High Very High
fibrosis 1 97.68 Very High Very High Very High
headache 15 95.20 Very High Very High Very High
Potency 3 94.48 High High
Disease Link Frequency Relevance Heat
Hemorrhage 50 100.00 Very High Very High Very High
Hemolysis 4 100.00 Very High Very High Very High
Overdose 6 99.80 Very High Very High Very High
Cv General 3 Under Development 11 99.28 Very High Very High Very High
Hepatotoxicity 2 99.26 Very High Very High Very High
Injury 8 99.08 Very High Very High Very High
Heparin-induced Thrombocytopenia 5 98.92 Very High Very High Very High
INFLAMMATION 6 98.36 Very High Very High Very High
Inflammatory Bowel Disease 3 97.80 Very High Very High Very High
Fibrosis 1 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NK 631 did not affect hemolysis and prothrombin time at 10(-4) g/ml.
Neg (not) Regulation (affect) of prothrombin associated with hemolysis
1) Confidence 0.61 Published 1978 Journal Jpn J Antibiot Section Abstract Doc Link 83413 Disease Relevance 0.33 Pain Relevance 0
Blood coagulation and fibrinolytic activity was studied in SART (specific alternation of rhythm in temperature)-stressed animals found to exhibit thrombocytopenia and prolonged bleeding time, and drug effects on the abnormalities were evaluated. 1) SART-stressed rats revealed prolongation of activated partial thromboplastin and thrombin time, no change in prothrombin time, decreased plasma fibrinogen levels, and shortened euglobulin clot lysis time (ELT).
Neg (no) Regulation (change) of prothrombin in plasma associated with congenital anomalies, hemorrhage and thrombocytopenia
2) Confidence 0.41 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1744984 Disease Relevance 0.51 Pain Relevance 0.06
M, IM and MT did not alter the prothrombin time of albino rats.
Neg (not) Regulation (alter) of prothrombin
3) Confidence 0.40 Published 1979 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 314790 Disease Relevance 0.60 Pain Relevance 0.13
Evaluation for hypercoagulable states revealed heterozygosity for prothrombin gene mutation and increased homocysteine level in one patient and mild elevation of anticardiolipin antibodies in two patients.
Regulation (heterozygosity) of prothrombin gene
4) Confidence 0.38 Published 2002 Journal J. Child Neurol. Section Abstract Doc Link 12269725 Disease Relevance 0.74 Pain Relevance 0.13
The prothrombin and partial thromboplastin time and the plasma levels of fibrinogen and antithrombin III remained unchanged by capsaicin or L-NAME, whereas the thrombin time was reduced in capsaicin-pretreated rats.
Neg (unchanged) Regulation (unchanged) of prothrombin in plasma associated with qutenza
5) Confidence 0.34 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8285224 Disease Relevance 0.17 Pain Relevance 0.86
Hematological examination revealed drug-induced thrombocytopenia, increase of FDP in blood (80 micrograms/ml), but no abnormality of prothrombin time and fibrinogen content.
Neg (no) Regulation (abnormality) of prothrombin in blood associated with heparin-induced thrombocytopenia
6) Confidence 0.32 Published 1985 Journal No Shinkei Geka Section Abstract Doc Link 4069318 Disease Relevance 1.63 Pain Relevance 0.20
Acetylcysteine treatment reduces liver damage after paracetamol overdose, but can affect the prothrombin index, which is used to assess the progress of overdose patients.
Regulation (affect) of prothrombin in liver associated with paracetamol, hepatotoxicity and overdose
7) Confidence 0.27 Published 2002 Journal Lancet Section Abstract Doc Link 12387966 Disease Relevance 0.67 Pain Relevance 0.31
Of 110 children, who ingested superwarfarins and in whom one or more prothrombin time values were obtained, 8 had a prothrombin time ratio (patient to control) of greater than or equal to 1.2, indicative of anticoagulation.
Regulation (values) of prothrombin
8) Confidence 0.27 Published 1989 Journal Pediatrics Section Abstract Doc Link 2771552 Disease Relevance 0.33 Pain Relevance 0.05
Furthermore, in studies in patients and normal volunteers stabilized on warfarin, nabumetone did not cause alterations in the prothrombin time or international normalized ratio.
Neg (not) Regulation (alterations) of prothrombin
9) Confidence 0.25 Published 1993 Journal Am. J. Med. Section Abstract Doc Link 8357000 Disease Relevance 0.23 Pain Relevance 0.20
No changes in prothrombin time an platelet adhesiveness, have been observed.
Neg (No) Regulation (changes) of prothrombin in platelet
10) Confidence 0.25 Published 1981 Journal Rev Med Univ Navarra Section Abstract Doc Link 7339763 Disease Relevance 0.29 Pain Relevance 0.11
The most dramatic changes in coagulation parameters were observed in thrombin time with virtually no changes in prothrombin time.
Neg (no) Regulation (changes) of prothrombin
11) Confidence 0.21 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11740955 Disease Relevance 0.66 Pain Relevance 0
In fact, there is no change at all in hepatic aminotransferase enzymes, prothrombin time, or other biochemical parameters when compared with a placebo group in well-designed trials.
Neg (no) Regulation (change) of prothrombin
12) Confidence 0.18 Published 2000 Journal Am J Ther Section Abstract Doc Link 11319580 Disease Relevance 0.58 Pain Relevance 0.88
RESULTS: We found considerable derangements in the international normalized ratio (INR), prothrombin time, activated partial thromboplastin time (aPTT), and platelet counts, with peak derangements occurring around postoperative day 2.
Regulation (derangements) of prothrombin in platelet
13) Confidence 0.18 Published 2007 Journal Hepatogastroenterology Section Body Doc Link 17708283 Disease Relevance 0 Pain Relevance 0
It is now recognized that the prothrombin time ratio depends on the activity of the thromboplastin used for measuring the prothrombin time.
Regulation (depends) of prothrombin
14) Confidence 0.18 Published 1994 Journal Dis Mon Section Abstract Doc Link 8076500 Disease Relevance 0.74 Pain Relevance 0.10
These findings are consistent with free thrombin concentrations in the nanomolar range sufficient to clot fibrinogen rapidly without visibly affecting the up to 1,000 fold higher concentrations of inhibitors and prothrombin.
Neg (without) Regulation (affecting) of prothrombin
15) Confidence 0.13 Published 1985 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 3867125 Disease Relevance 0.47 Pain Relevance 0.14
No correlation was found with liver damage as assessed by the prolongation of the prothrombin time, serum AST or bilirubin values.
Regulation (values) of prothrombin in liver associated with hepatotoxicity
16) Confidence 0.12 Published 1988 Journal Hepatology Section Abstract Doc Link 2828215 Disease Relevance 1.33 Pain Relevance 0.32
Aspirin at a mean serum concentration of 84 micrograms/ml did not affect prothrombin time, partial thromboplastin time, platelet count, or bleeding time.
Neg (not) Spec (partial) Regulation (affect) of prothrombin in platelet associated with aspirin and hemorrhage
17) Confidence 0.10 Published 1988 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3259170 Disease Relevance 0.19 Pain Relevance 0.62
Ketorolac did not affect the prothrombin time or partial thromboplastin time but was associated with clinically insignificant change in the platelet count from 303 +/- 57 X 10(3)/m3 to 277 +/- 56 X 10(3)/mm3.
Neg (not) Spec (partial) Regulation (affect) of prothrombin in platelet associated with acular
18) Confidence 0.10 Published 1988 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3259170 Disease Relevance 0.19 Pain Relevance 0.59
In addition, it had no effect on platelet aggregation, prothrombin time and activated partial thromboplastin time. 6.
Neg (no) Spec (partial) Regulation (effect) of prothrombin in platelet
19) Confidence 0.07 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9450167 Disease Relevance 0.33 Pain Relevance 0.32
Postoperative changes in various haemostatic parameters (capillary bleeding time, platelet count, fibrinogen, fibrinmonomers, prothrombin, antithrombin III, factor VIII procoagulant, factor VIII antigen, euglobulin clot lysis time, streptokinase lysis time, fibrinogen related antigens, alpha 1-antitrypsin and alpha 2-macroglobulin) plasma glucose and cortisol were studied in 12 female patients undergoing elective abdominal hysterectomy during either general anaesthesia or epidural analgesia (T4-S5).
Regulation (changes) of prothrombin in plasma associated with epidural, hemorrhage and analgesia
20) Confidence 0.07 Published 1981 Journal Br J Surg Section Abstract Doc Link 7225737 Disease Relevance 0.10 Pain Relevance 0.33

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